Tavşanlarda Postoperatif İntraabdominal Adezyonların Önlenmesinde Hyaluronik asit/Karboksimetilselüloz Bariyerlerin Etkinliği

İntraabdominal adezyonlar; abdominopelvik cerrahide karşılaşılan yaygın komplikasyonlardan biridir. Bu çalışmanın amacı; tavşanlarda postoperatif intraabdominal adezyonların önlenmesinde hyaluronik asit/karboksimetilselüloz (HA/KMS) bariyerlerin etkinliğinin ortaya konulmasıdır. Çalışmada 14 adet Yeni Zelanda tavşanı kullanıldı. Median laparatomiden sonra sekumda 2x2 cm2 lik alanda serozal abrazyon oluşturuldu. Tavşanlar kontrol ve deney gruplarına ayrıldı. Kontrol grubundaki olgulara herhangi bir tedavi uygulanmadı. Deney grubundaki travmatize edilen bölgeye 3x3 cm2 lik HA/KMS bariyeri örtüldü. Postoperatif 14. günde ötenazi uygulandı. Makroskopik değerlendirmeler sonucunda; deney grubundaki olguların adezyon dereceleri kontrol grubuna oranla istatistiksel olarak anlamlı derecede az bulundu (P

The Efficacy of Hyaluronic Acid/Carboxymethylcellulose Barriers on the Prevention of Postoperative Intraabdominal Adhesions in Rabbits

Intraabdominal adhesions are one of the common complications seen in abdominopelvic surgery. The purpose of this study was to assess the efficacy of hyaluronic acid/carboxymethylcellulose (HA/CMC) barriers in preventing postoperative intraabdominal adhesions in rabbits. Fourteen rabbits were used in this study. The 2x2 cm part of caecum was meticulously abraded after median laparotomy. The rabbits were divided into the control and experiment groups. No medication was given to the control group. In the experiment group; a 3x3 cm of HA/CMC barrier was covered on the abraded area. Euthenasia was performed on the 14th day postoperative. The results of macroscopic evaluation showed that adhesion scores in the experiment group were found lower than in the control group (P

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