Fucus vesiculosus ve Laminaria digitata Ekstraktlarının Prostat ve Seminal Vezikül p-PDE5, cGMP, eNOS ve ET-1 Düzeyleri Üzerine Etkileri

Üreme sağlığı yaşam kalitesinin önemli belirteçlerinden biridir. Günümüzde erkek bireylerde düşük libido, erektil disfonksiyon, prematür ejakülasyon, gecikmiş veya inhibe orgazm gibi cinsel işlev bozuklukları giderek yaygın hale gelmektedir. Cinsel işlev bozukluklarının tedavisi için destek tedaviler arasında fito ve etnoterapiler günümüz dünyasında popülerlik kazanmaktadır. Fucus vesiculosus (FV) ve Laminaria digitata (LD), antioksidan, anti-tümör, antikoagülan, anti obezitik, anti inflamatuar, antiviral ve antibakteriyel aktivitelere sahiptirler. Bu çalışmanın amacı, FV ve LD ekstraktlarının üzerine prostat ve seminal vezikül dokularında fosfodiesteraz tip 5 (p-PDE5), siklik guanozin monofosfat (cGMP), endotel nitrik oksit sentaz (eNOS) ve endotelin‑1 (ET-1) protein düzeyleri üzerine etkilerini araştırmaktır. Çalışmada, toplam 21 adet erkek 12 haftalık SpragueDawley ırkı sıçan kullanıldı. Sıçanlar üç gruba ayrıldı: 1) Kontrol grubu, 2) FV grubu ve 3) LD grubu. FV ve LD 300 mg/kg CA dozunda gavaj yoluyla 52 gün boyunca günlük olarak hayvanlara verildi. Prostat dokusunda kontrol grubuna göre, FV ve LD verilen gruplarda p-PDE5 (P

Effects of Fucus vesiculosus and Laminaria digitata Extracts on Prostate andSeminal Vesicle p-PDE5, cGMP, eNOS and ET-1 Levels

Reproductive health is one of the important indicators of life quality. Today, sexual dysfunctions such as low libido, erectile dysfunction, premature ejaculation, delayed or inhibited orgasm are becoming increasingly common in male individuals. Among the supportive treatments for the treatment of sexual dysfunctions, phyto and ethno therapies are gaining popularity in today's world. Fucus vesiculosus (FV) and Laminaria digitata (LD) have antioxidant, anti-tumor, anticoagulant, anti-obesity, anti-inflammatory, antiviral and antibacterial activities. The aim of this study was to investigate the effects of FV and LD extracts on protein levels of phosphodiesterase type 5 (pPDE5), cyclic guanosine monophosphate (cGMP), endothelial nitric oxide synthase (eNOS) and endothelial-1 (ET-1) in prostate and seminal vesicular tissues. A total of 21 male 12-week-old Sprague-Dawley rats were used in the study. The rats were divided into three groups. 1) Control group, 2) FV group and 3) LD group. FV and LD were administered daily for 52 days via gastric gavage at a dose of 300 mg/kg BW. Among FV and LD groups, the prostate tissues, p-PDE5 (P

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