Burak KARABULUT, Burak Fatih YÜKSEL, Kerem ERCAN, Canan AKDENİZ İNCİLİ, Cahit KALKAN

Bir Buzağı Fetüsünde Karşılaşılan Pulmoner Hipoplazi ve Anasarka Sendromu ile Palatoşizis Olgusu

Pulmoner hipoplazi ve anasarka (PHA) sendromu, subkutan ödem, gelişmemiş akciğerler ve fetal hidropsi ile karakterize sığırların öldürücü bir genetik bozukluğudur. Sunulan olguyu 2 yaşlı Simental ırkı bir düveden sezaryen operasyonu ile alınan buzağı fetüsü oluşturdu. Çıkarılan fetüsün deri altı dokuları arasında yoğun sıvı toplandığı görüldü. Patolojik olarak hayvanda yaygın ve şiddetli deri altı ödem, üst damakta total palatoşizis, akciğerlerin normalden küçük hacimli, atelektatik ve hipoplastik, kalbin ise çift taraflı dilate olduğu tespit edildi. Mikroskobik incelemede kalp ve akciğerde epikardiyal ve endokardiyal dokuda ödem, endokardiyal fibrozis, akciğerlerde ise fetal atelektazi ile perivasküler ve intersitisyel ödem gibi önemli histopatolojik bulgular gözlendi. Sonuç olarak bu olgunun, hayvanlarda nadir olarak gözlenmesi, anasarka ve anomali ile karakterize Türkiye‟de bildirilen ilk vaka olması nedeniyle vakanın bildirimi yapılmıştır.

A Case of Pulmonary Hypoplasia and Anasarca Syndrome with Palatoschisis in a Calf Fetus

Pulmonary hypoplasia and anasarca syndrome is a lethal genetic disorder of cattle characterized by excessive subcutaneous edema, undeveloped lungs and fetal hydrops. In this case report, a calf fetus delivered by the cesarean section from a two-year-old Simental breed heifer was presented. Intense fluid was collected between the subcutaneous tissues of the extracted calf. Pathologically, it was found that the animal had diffuse and severe subcutaneous edema, total palatoschisis in the upper palate, the lungs were smaller than normal, atelectatic and hypoplastic, and the heart was bilaterally dilated. Microscopic examination revealed significant histopathologic findings such as epicardial and endocardial edema in the heart and lungs, endocardial fibrosis, fetal atelectasis in the lungs, and perivascular and interstitial edema. This is the first report in Turkey characterized by anasarca and malformation, suggesting this is a rare case in animals.

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