FOLİKÜLER DENDRİTİK HÜCRELER

Foliküler dendritik hücre (FDH)’ler lenf düğümleri, dalak ve tonsillalardaki lenf foliküllerinde bulunurlar. Antijen sunan bu hücreler komşu lenfoid hücrelerin arasına uzanan çok sayıda sitoplazmik uzantılar (dendrit) ile karekterizedirler. FDH’ler germinal merkez mikroçevresinin bir anahtar hücresel kompenenti olarak bi-linmektedir. Bu hücreler antijen antikor kompleksini elde edip korur, hafıza B hücrelerini uyarabilir ve sonra daha ileri T hücre aktivitesini uyarabilirler. Antijen, yerleştiği FDH’ler üzerinde uzun zaman kalır ve bu özel-lik bazı enfeksiyon hastalıkları için çok önemlidir. Bu derlemede FDH’ler geniş bir bakış açısından incelen-mişlerdir.

Anahtar Kelimeler:

Foliküler Dendritik Hücreler, Antijen Sunan Hücreler, Antijenik Uyarım

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