Erdal İNA, Mehmet Mustafa AKIN, Müge OTLU, Gökhan VARLI, FİGEN DEVECİ, Mehmet Hamdi MUZ

Akciğerin Primer Taşlı Yüzük Hücreli Karsinomu: Olgu Sunumu

Adenokarsinomun bir alt tipi olan taşlı yüzük hücreli karsinom (TYHK), çoğunlukla mide, kolon, mesane, prostat ve memenin primer karsinomu olarak ortaya çıkar. Kötü prognozlu bu tümör, akciğerin primer hastalığı olarak oldukça nadir görülür ve akciğerlerde saptandığı zaman sıklıkla metastaz olduğu düşünülür. Akciğerde TYHK tespit edildiğinde mide, kolon, mesane, prostat veya meme kanserininin metastazı olmadığının ortaya konulması çok önemlidir. Malign bir tümör olan bu türün en önemli özelliği, müsin üreten hücrelerin varlığıdır. Primer ve metastatik tümörlere klinik yaklaşımın farklı olması nedeniyle ayırıcı tanının önemini vurgulamak amacıyla bu olguyu sunduk

Primary Signet Ring Cell Carcinoma of the Lung: A Case Report

Signet ring cell carcinoma (SRCC), a subtype of adenocarcinoma, is observed usually as the primer cancers of stomach, large intestine, bladder, prostate and breast. SRCC which has poor prognosis is rarely occured as primary lung cancer and the vast majority of SRCC found in the pulmonary system is metastatic. In making the diagnosis of SRCC in the lung, it is very important to exclude metastatic SRCC from the stomach, colon, bladder, prostate and breast. The main feature of this type of malignancy is mucin-producing cells. We reported this case for to point out the importance of differential diagnosis of primary and metastatic tumors, since they require different clinical approaches

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Dela Cruz CS,Tanoue LT,Matthay RA. Lungcancer: epidemiology, etiology, and prevention. Clin Chest Med2011; 32: 605-44.
Yousem SA, Beasley MB. Bronchioloalveolar Carcinoma: A Review of Current Concepts and Evolving Issues. Arch of Path and Lab Med 2007;131: 1027-32.3
Ohba T,Sugio K,Kometani T, et al. Signet ring cell adenocarcinomaof thelungwith anEML4-ALKfusiongenemimickingmucinous(colloid) adenocarcinoma: acase report. LungCancer2011; 73: 375-8.
Tsuta K, Ishii G, Yoh K, et al. Primary lung carcinoma with signetring cell carcinoma components, clinicopathological analysis of39 cases. Am J Surg Pathol 2004; 28: 868-74.
Kish JK, Ro JY, Ayala AG, et al. Primary mucinous adenocarcinoma of the lung with signet-ring cells: a histochemical comparison with signet-ring cell carcinomas of the other sites. Hum Pathol1989; 20: 1097-1102.
Brambilla E,Travis WD,Colby TV,et al. The new World Health Organization classification of lung tumours. Eur Respir J2001; 18:1059-68.
Castro CY, Moran CA, Flieder DG, Suster S. Primary signet ring cell adenocarcinoma of the lung: a clinicopathological study of 15 cases. Histopathology 2001; 39: 397-401.
Ou SH,Ziogas, A,Zell JA. Primarysignet-ringcarcinoma (SRC) of thelung: apopulation-basedepidemiologicstudy of262caseswithcomparison toadeno carcinomaof thelung. JThorac Oncol2010; 5: 420-7.