Akut Romatizmal Ateş Tanılı Çocuklarda MPV ve PCT Parametrelerinin Değerlendirilmesi

Amaç: Bu çalışmanın amacı, akut romatizmal ateş (ARA) hastalarında akut dönem ve tedavi sonrası izlemde sağlıklı gruba göre, ortalama trombositvolümü (MPV) ve kandaki trombosit yüzdesi olan platelet crit'in (PCT) enflamasyonu göstermede ve takibinde kullanışlı bir araç olup olmadığını göstermekti. Gereç ve Yöntem: 47 ARA tanılı çocuk ve 40 sağlıklı çocuk çalışmaya dahil edildi. Trombosit indeksleri ve inflamatuar parametreler tüm çocuklar için ölçüldü. Hastalığın erken ve geç fazındaki trombosit indeksleri, sağlıklı çocukların değerleri ile karşılaştırıldı. Bulgular: ARA tanılı çocuklar ve sağlıklı çocuklar arasında yaş, cinsiyet ve vücut kitle indeksi açısından anlamlı farklılık tespit edilmedi. ARA grubundaki MPV değeri, sağlıklı gruba göre daha düşüktü. Ancak, tespit edilen bu düşüklük, istatistiksel olarak anlamlı değildi (p=0.177). PCT değeri ARA'lı çocuklarda anlamlı olarak daha yüksek gözlendi (p

Evaluation of MPV and PCT Parameters in Children with Acute Rheumatic Fever

Objective: The aim of this study was to show whether mean platelet volume (MPV) and platelet-crit (PCT) were useful tools for determining and following up inflammation during the acute phase and follow-up after treatment in patients with acute rheumatic fever (ARF) compared to the healthy group. Material and Method: 47 children with ARF and 40 healthy children were included in the study. Platelet indices and inflammatory parameters were measured for all children. Platelet indices of acute and remission phase of the disease were compared with the values of healthy children. Results: It was not detected statistically significant differences between children with ARF and healthy children with respect to age, gender and body mass index. MPV value in ARF group was lower than the healthy group. However, the detected this decrease was not statistically significant (p=0.177). PCT value was significantly higher in children with ARF (p<0.001). By the children with ARF it was determined that white blood cells count and platelet count (PLT) values have shown a significant increase, while hemoglobine values determined also significant decrease (p<0.001 for all parameters). It was not detected a significant difference between MPV values of acute and remission phase in the patients with ARF. PCT and PLT values in the both acute and remission phase by the patients with ARF were significantly higher compared the healthy group (p=0.021, p=0.015; p=0.006, p=0.029, respectively). Conclusion: We consider that PCT as well as PLT may be used as valuable parameters in follow-up of patients diagnosed with ARF

PDF

___

1.Narin N, Mutlu F, Argun M, et al. Incidence and clinical features of acute rheumatic fever in Kayseri, Central Anatolia, 1998-2011. Cardiol Young2015; 25:745-51.
2.Yalçın K. Role of platelets in inflammation. Dicle Medical Journal / Dicle Tip Dergisi 2012;39:455-7.
3.Beyan C, Kaptan K, Ifran A. Platelet count, mean platelet volume, platelet distribution width, and plateletcrit do not correlate with optical platelet aggregation responses in healthyvolunteers. J Thromb Thrombolysis 2006;22:161-4.
4.Akbal A, Gokmen F, Gencer M, Inceer BS, Komurcu E. Mean platelet volume and platelet distribution width can be related to bone mineralization. Osteoporos Int 2014;25:2291-5.
5.Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis 1996;7:157-61.
6.Chakravarty SD, Zabriskie JB, Gibofsky A. Acute rheumatic fever and streptococci: the quintessential pathogenic trigger of autoimmunity. Clin Rheumatol 2014;33:893-901.
7.Voudoukis E, Karmiris K, Koutroubakis IE. Multipotent role of platelets in inflammatory bowel diseases: a clinical approach. World J Gastroenterol 2014;20:3180-90.
8.Balta I, Balta S, Aparci M, Demirkol S, Ozturk C. Mean platelet volume in patients with systemic lupus erythematosus. Clin Rheumatol 2014: doi 10.1007/s10067-014-2705-0.
9.Sun WX, Zhang JR, Cao ZG, Li Y, Wang RT. A decreased mean platelet volume is associated with stable and exacerbated asthma. Respiration 2014;88:31-7.
10.Oncel MY, Ozdemir R, Yurttutan S, et al. Mean platelet volume in neonatal sepsis. J Clin Lab Anal 2012;26:493-6
11.Yazici S, Yazici M, Erer B, et al. The platelet indices in patients with rheumatoid arthritis: mean platelet volume reflects disease activity. Platelets 2010;21:122-5.
12.Öztürk ZA, Dağ MS, Kuyumcu ME, et al. Could platelet indices be new biomarkers for inflammatory bowel diseases? European Review for Medical and Pharmacological Sciences 2013;17:334-41.
13.Becchi C, Al Malyan M, Fabbri LP, Marsili M, Boddi V, Boncinelli S. Mean platelet volume trend in sepsis: is it a useful parameter? Minerva Anestesiol 2006;72:749-56.
14.Liu R, Gao F, Huo J, Yi Q. Study on the relationship between mean platelet volume and platelet distribution width with coronary artery lesion in children with Kawasaki disease. Platelets 2012;23:11-6.
15.Ozdemir R, Karadeniz C, Doksoz O, et al. Are mean platelet volume and platelet distribution width useful parameters in children with acute rheumatic carditis? Pediatr Cardiol 2014;35:53-6.
16.Sert A, Aypar E, Odabas D. Mean platelet volume in acute rheumatic fever. Platelets 2013;24:378-82.