Transient Reseptör Potansiyel Vanilloid 1 Kanalları ve Böbrek

Transient reseptör potansiyel vanilloid 1 (TRPV1) pozitif sensoriyal sinirlerin kardiyovasküler fonksiyonlar, kan basıncı ve vücut ağırlığı üzerinde önemli rol oynadığı gösterilmiştir. Böbreklerde TRPV1'in aktivasyonu glomerüler filtrasyon hızını ve renal sodyum ve su ekskresyonunu artırır. TRPV1 aktivasyonunun kronik böbrek yetmezliği sürecinde renal fibrozis üzerine yararlı etkileri olabileceği yönünde bulgular vardır. Ayrıca TRPV1 agonistleri akut iskemik böbrek hasarında da renoprotektif rol oynamaktadır

Transient Receptor Potential Vanilloid 1 Channels and Kidney

Transient receptor potential vanilloid 1 (TRPV1) positive sensory nerves have been shown to play important roles on cardiovascular functions, blood pressure and body weight. Activation of TRPV1 in the kidney increases the glomerular filtration rate and renal sodium and water excretion. Activation of TRPV1 have been shown to have beneficial effects on renal fibrosis in chronic renal failure in process. Additionally, TRPV1 agonists also play renoprotective role in acute ischemic renal injury

Kaynakça

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