Aslı ÖZKIZILCIK KOÇYİĞİT, Tülay KILIÇASLAN AYNA, Mustafa SOYÖZ

The Assessment of microRNA Role in Kidney Transplantation

miRNAs are short, single stranded, noncoding RNA molecules with approximately 22 nucleotides. They play crucial roles in posttranscriptional regulation. To date, more than 21,000 mature miRNAs have been discovered from 193 species. miRNAs are important in renal physiology. Their expressions may be specific to different organs and tissues, or the same miRNAs may be expressedin different organs. With this discovery, it has been reported that tissue-specific miRNAs can be used as biomarkers for allograftrejection and ischemia reperfusion injury following renal transplantations. Although allograft biopsy is accepted as a gold standard, scientists have been developing novel approaches to prevent the associated risks, such as bleeding and infection, followingbiopsy. Recently, several attempts have been made in terms of the use of urine as a noninvasive material instead of biopsy samples.However, no procedure is available for routine testing. Therefore, further investigations are warranted.

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Zou, Q, Mao Y, Hu L, Wu Y, Ji Z. miRClassify: an advanced web server for miRNA family classification and annotation. Comput Biol Med 2014; 45: 157-60. [CrossRef]
Wahid F, Shehzad A, Khan T, Kim YY. MicroRNAs: Synthesis, mechanism, function, and recent clinical trials. Biochim Biophys Acta 2010; 1803: 1231-43. [CrossRef]
Ameres SL, Zamore PD. Diversifying microRNA sequence and function. Nat Rev Mol Cell Biol 2013; 14: 475-88. [CrossRef]
Trionfini P, Benigni A, Remuzzi G. MicroRNAs in kidney physiology and disease. Nat Rev Nephrol 2015; 11: 23-33. [CrossRef]
Rana TM. Illuminating the silence: understanding the structure and function of small RNAs. Nat Rev Mol Cell Biol 2007; 8: 23-36. [CrossRef]
Winter J, Jung S, Keller S, Gregory RI, Diederichs S. Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol 2009; 11: 228-34. [CrossRef]
Boon RA, Vickers KC. Intercellular Transport of MicroRNAs. Arterioscler Thromb Vasc Biol 2013; 33: 186-92. [CrossRef]
Vickers KC, Palmisano BT, Shoucri BM, Shamburek RD, Remaley AT. MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins. Nat Cell Biol 2011; 13: 423- 33. [CrossRef]
Lorenzen JM, Thum T. Circulating and Urinary microRNAs in Kidney Disease. Clin J Am Soc Nephrol 2012; 7: 1528-33. [CrossRef]
Pritchard CC, Cheng HH, Tewari M. MicroRNA profiling: approaches and considerations. Nat Rev Genet 2012; 13: 358-69. [CrossRef]
Shan J, Feng L, Luo L, Wu W, Li C, Li S, et al. MicroRNAs: Potential biomarker in organ transplantation. Transpl Immunol 2011; 24: 210-5. [CrossRef]
Martinez-Nunez RT, Louafi F, Friedmann PS, Sanchez-Elsner T. MicroRNA-155 Modulates the Pathogen Binding Ability of Dendritic Cells (DCs) by Down-regulation of DC-specific Intercellular Adhesion Molecule-3 Grabbing Non-integrin (DC-SIGN). J Biol Chem 2009; 284: 16334-42. [CrossRef]
Jiang Y, Wang R, Wang H, Huang H, Peng W, Qiu W, et al. The Effect of Histological CD20-Positive B Cell Infiltration in Acute Cellular Rejection on Kidney Transplant Allograft Survival. J Immunol Res 2016; 2016: 7473239. [CrossRef]
Shapiro MD, Bagley J, Latz J, Godwin JG, Ge X, Tullius SG, et al. MicroRNA Expression Data Reveals a Signature of Kidney Damage following Ischemia Reperfusion Injury. PLos One 2011; 6: e23011. [CrossRef]
Mas VR, Dumur CI, Scian MJ, Gehrau RC, Maluf DG. MicroRNAs as Biomarkers in Solid Organ Transplantation. Am J Transplant 2013; 13: 11-9. [CrossRef]
Scian MJ, Maluf DG, David KG, Archer KJ, Suh JL, Wolen AR, et al. MicroRNA profiles in allograft tissues and paired urines associate with chronic allograft dysfuncion with IF/TA. Am J Transplant 2011; 11: 2110-22. [CrossRef]
Pirim İ, Soyöz M, Ayna TK, Koçyiğit AO, Gürbüz BC, Tuğmen C, et al. De novo Produced Anti-HLA Antibodies Relation To Alloimmunity in Patients with Chronic Renal Failure. Genet Test Mol Biomarkers 2015; 19: 335-8. [CrossRef]
Ayna TK, Soyöz M, Kurtulmuş Y, Doğan SM, Özyılmaz B, Tuğmen C, Pirim I. Comparison of complement-dependent cytotoxic and flow-cytometry crossmatch results before cadaveric kidney transplantation. Transplant Proc 2013; 45: 878-90. [CrossRef]
Soyöz M, Kılıçaslan-Ayna T, Özkızılcık-Koçyiğit A, Güleç D, Pirim İ. Single Antigen Flow Beads for Identification of Human Leukocyte Antigen Antibody Specifities in Hypersensitized Patients with Chronic Renal Failure. Cent Eur J Immunol 2016; 41: 93-100. [CrossRef]
van den Akker EK, Dor FJ, Ijzermans JN, de Bruin RW. MicroRNAs in Kidney Transplantation: Living up to Their Expectations? J Transplant 2015; 2015: 354826.
Godwin JG, Ge X, Stephan K, Jurisch A, Tullius SG, Iacomini J. Identification of a microRNA signature of renal ischemia reperfusion injury. Proc Natl Acad Sci USA 2010; 107: 14339-44. [CrossRef]
Scian MJ, Maluf DG, Mas VR. miRNAs in kidney transplantation: potential role as new biomarkers. Expert Rev Mol Diagn 2013; 13: 93- 104. [CrossRef]
van de Vrie M, Deegens JK, Eikmans M, van der Vlag J, Hilbrands LB. Urinary MicroRNA as Biomarker in Renal Transplantation. Am J Transplant 2017; 17: 1160-6. [CrossRef]
Maluf DG, Dumur CI, Suh JL, Scian MJ, King AL, Cathro H, et al. The urine microRNA profile may help monitor post-transplant renal graft function. Kidney Int 2014; 85: 439-49. [CrossRef]