Risk Factors for Mother to Child Transmission of HIV in Southwest Ethiopia

Risk Factors for Mother to Child Transmission of HIV in Southwest Ethiopia

Objective: One in four Ethiopian children born to human immunodeficiency virus (HIV) positive mothers were found to have acquired the virus, although the country has been implementing the World Health Organization’s(WHO) four-pronged prevention approaches. This study was therefore aimed at identifying the factors responsible for mother to child transmission of HIV among children who received HIV exposure care.Methods: An unmatched case-control study was conducted on randomly selected 64 cases and 256 controls from December 2011 to May 2012. The cases were HIV positive children less than 18 months of age, and the controls were HIV negative children less than 18 months of age born to HIV positive mothers. Data on the parents’sociodemographic characteristics and parents’ clinical profiles before the final child’s HIV status determination were collected. A logistic regression was used to identify predictors.Results: The records of 60 casesand 235 controls were included for analysis. Mixed breastfeeding(adjusted odd ratio [AOR]: 22.03; 95% confidence interval [CI]:5.31–91.49), maternal CD4 count

___

  • Joint United Nations Programme on HIV/AIDS (UNAIDS). Progress report on the global plan towards the elimination of new HIV infections among children by 2015 and keeping their mothers alive. Available from: http:// www.unaids.org/sites/default/files/documents/JC2681_2014-GlobalPlan-progress_en.pdf (accessed date: July 10,2012)
  • UNAIDS (2015). Countdown to Zero - Global Plan towards the Elimination of New HIV Infections among Children by 2015 and Keeping Their Mothers Alive. Available from http://www.unaids.org/sites/ default/files/media_asset/20110609_JC2137_Global-Plan-Elimination-HIV-Children_en_1.pdf (accessed date: July 10,2012)
  • World Health Organization (WHO). How AIDS changed everything – executive summary. MDG 6: 15 years, 15 lessons of hope from the aids response. Available from http://www.unaids.org/en/resources/ documents/2015/MDG6_report_executive-summary: July 10,2012)
  • Landesman SH, Kalish LA, Burns DN, Minkoff H, Fox HE, Zorrilla C, et al. Obstetrical factors and the transmission of human immunodeficiency virus type 1 from mother to child. The Women and Infants Transmission Study. N Engl J Med 1996; 33:1617-23. [CrossRef]
  • King CC, Ellington SR, Kourtis AP. The role of co-infections in motherto-child transmission of HIV. Curr HIV Res 2013; 11:10-23. [CrossRef]
  • Mofenson LM. Mother-child HIV-1 transmission: Timing and determinants. Obstet Gynecol Clin North Am 1997; 24: 759-84. [CrossRef]
  • Connor EM, Sperling RS, Gelber R, Kiselev P, Scott G, O’Sullivan MJ, et al. Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group. N Engl J Med 1994; 33: 1173-80. [CrossRef]
  • John GC, Kreiss J. Mother-to-child transmission of human immunodeficiency virus type 1. Epidemiol Rev 1996; 18: 149-57. [CrossRef]
  • Shaffer N, Chuachoowong R, Mock PA, Bhadrakom C, Siriwasin W, Young NL, et al. Short-course zidovudine for perinatal HIV-1 transmission in Bangkok, Thailand: a randomised controlled trial. Bangkok Collaborative Perinatal HIV Transmission Study Group. Lancet 1999; 353:773-80. [CrossRef]
  • Jamieson DJ, Sibailly TS, Sadek R, Roels TH, Ekpini ER, Boni-Ouattara E, et al. HIV-1 viral load and other risk factors for mother-to-child transmission of HIV-1 in a breast-feeding population in Cote d’Ivoire. J Acquir Immune DeficSyndr 2003; 34: 430-6. [CrossRef]
  • Jackson JB, Musoke P, Fleming T, Laura A G, Danstan B, Melissa A, et al. Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: 18-month follow-up of the HIVNET 012 randomized trial. Lancet 2003; 362:859-68. [CrossRef]
  • Federal HIV/AIDS Prevention and Control Office (FHAPCO). Report on progress towards implementation of the UN Declaration of Commitment on HIV/AIDS, Addis Ababa, Ethiopia, 2010. Available from http://data.unaids.org/pub/Report/2010/ethiopia_2010_country_ progress_report_en.pdf (accessed date: July 10,2012)
  • Iliff PJ, Piwoz EG, Tavengwa NV, Zunguza CD, Marinda ET, Nathoo KJ, et al. Early exclusive breastfeeding reduces the risk of postnatal HIV-1 transmission and increases HIV-free survival. AIDS 2005; 19: 699-708. [CrossRef]
  • Aluisio A, Richardson BA, Bosire R, John-Stewart G, Mbori-Ngacha D, Farquhar C. Male antenatal attendance and HIV testing are associated with decreased infant HIV infection and increased HIV-free survival. J Acquir Immune DeficSyndr 2011; 56: 76-82. [CrossRef]
  • Maru Y, Haidar J. Infant feeding practice of HIV positive mothers and its determinants in selected health institutions. Ethiop J Health Dev 2009; 23: 107-14.
  • Byamugisha R1, Tumwine JK, Semiyaga N, Tylleskär T. Determinants of male involvement in the prevention of mother-to-child transmission of HIV programme in Eastern Uganda: a cross-setional survey. Reprod Health 2010; 7: 12. [CrossRef]
  • World Health Organization (WHO). WHO recommendations on the diagnosis of HIV infection in infants and children. Available from http://www.who.int/hiv/pub/paediatric/diagnosis/en/(accessed date: July 10,2012)
  • Maru S, Datong P, Selleng D, Mang E, Inyang B, Ajene A, et al. Social determinants of mixed feeding behaviour among HIV infected mothers in Jos, Nigeria. AIDS Care 2009; 21: 1114-23. [CrossRef]
  • Oladokun RE, Brown BJ, Osinusi K. Infant-feeding pattern of HIV-positive women in a prevention of mother-to-child transmission (PMTCT) programme. AIDS Care 2010; 22: 1108-14. [CrossRef]
  • Becquet R, Ekouevi DK, Menan H, Amani-Bosse C, Bequet L, Viho I, et al. Early mixed feeding and breastfeeding beyond 6 months increase the risk of postnatal HIV transmission: ANRS 1201/1202 Ditrame Plus, Abidjan, Côte d’Ivoire.Prev Med 2008; 47:27-33. [CrossRef]
  • Moland KM, de Paoli MM, Sellen DW, van Esterik P, Leshabari SC, Blystad A. Breastfeeding and HIV: experiences from a decade of prevention of post-natal HIV transmission in sub-Saharan Africa. Int Breastfeed J, 2010; 5: 10. [CrossRef]
  • WHO/UNAIDS/UNICEF. HV transmission through breastfeeding: a review of available evidences: an update from 2001 to 2007. Available from. http://whqlibdoc.who.int/publications/2008/9789241596596_ eng.pd( accessed date: July 10,2012)
  • Kovalchik SA. Mother’s CD4+ cell count moderates the risk associated with higher parity for late postnatal HIV-free survival of breastfed children: an individual patient data meta-analysis of randomized controlled trials. AIDS Behav 2012; 16: 79-85. [CrossRef]
  • Creek TL, Sherman GG, Nkengasong J, Lu L, Finkbeiner T, Fowler MG, et al. Infant human immunodeficiency virus diagnosis in resource limited settings: issues: technologies: and country experiences. Am J ObstetGynecol2007; 197: 64-71. [CrossRef]
  • Tubiana R, Le Chenadec J, Rouzioux C, Mandelbrot L, Hamrene K, Dollfus C, et al. Factors Associated with Mother-to-Child Transmission of HIV-1 Despite a Maternal Viral Load !500 Copies/mL at Delivery: A Case-Control Study Nested in the French Per natal Cohort (EPF-ANRS CO1). Clin Infect Dis 2010; 50: 585-96. [CrossRef]
  • Federal HIV/AIDS Prevention and Control Office (FHAPCO). Guidelines for Prevention of Mother-to-Child Transmission of HIV. Available from http://www.ilo.org/wcmsp5/groups/public/- --ed_protect/---protrav/---ilo_aids/documents/legaldocument/ wcms_125389.pdf (accessed date : July 10,2012)
  • Cook RE, Ciampa PJ, Sidat M, Blevins M, Burlison J, Davidson MA, et al. Predictors of successful early infant diagnosis of HIV in a rural district hospital in Zambezia, Mozambique. J Acquir Immune DeficSyndr 2011; 56: 104-9. [CrossRef]
European Journal of Therapeutics-Cover
  • ISSN: 2564-7784
  • Başlangıç: 1990
  • Yayıncı: Fatma Taşçı
Sayıdaki Diğer Makaleler

The Assessment of microRNA Role in Kidney Transplantation

Aslı ÖZKIZILCIK KOÇYİĞİT, Tülay KILIÇASLAN AYNA, Mustafa SOYÖZ

Use of Mirror Therapy to Treat Psychogenic Tremors

Tomris DUYMAZ

Evaluation of Pulmonary Vein Variations Using Multidetector Computed Tomography

Mehmet DEMİR, Feyza GELEBEK YILMAZ

Lateral Sagittal Infraclavicular Block for Orthopedic Surgery: One Year Experience

Ümit KARADENİZ, Onur PALABIYIK, Havva SAYHAN, Ayça TAŞ TUNA, Yakup TOMAK, Yaşar TOPTAŞ, Tuğba ÇAĞLAR, Fikret BAYAR

Odontogenic Keratocyst Masquerading as a Dentigerous Cyst in the Maxilla: A Case Report of an Unusual Presentation

Arathi KUDTHADKA, Arvind KARİKAL, Triphi SHETTY

Evaluation of the Effectiveness of Web-based Intervention for Patients with Breast Cancer

Dilek ÖZTAŞ, Birgül ÖZKAN, Reyhan ESKİYURT

Risk Factors for Mother to Child Transmission of HIV in Southwest Ethiopia

Abiot Girma SİME, Birtikuan Tsehayneh ADAMU, Lamessa Dube AMENTİE, TsegayeTewelde GEBREHİWOT, Fessahaye Alemseged TESFAMİCHAEL

Polyclonal Antibody Production Against HaptenStructured KDN Molecule by Using Different Adjuvants Alternative to Freund’s Adjuvant

Ilgın KIMIZ, Sultan GÜLÇE İZ, Saime İsmet DELİLOĞLU GÜRHAN, Pelin SAĞLAM METİNER, Çağlar KAYALI

Echocardiographic and Laboratory Findings of Turkish Children during the First Attack of Acute Rheumatic Fever

Ayhan PEKTAŞ, Erman ÇİLSAL, Buğra H. KOCA, Bilgehan M. PEKTAŞ

Vein of Galen Aneurysmal Malformation Presenting with Macrocephaly

Halil KAZANASMAZ, Hüseyin GÜMÜŞ, Mustafa ÇALIK