MELEN çalışması, mantık, metot ve temel bulgular

Aim: The aim of the Melen Study was to investigate the cardiovascular risk profile of Turkish adults by utilizing newest techniques. Besides prevalence and types of endemic goiter will be established which was an important health problem in the Black sea region Method: The study was conducted on 2230 participants (1427 women, 803 men with a mean age of 49). The participants underwent a Doppler Ultrasound examination of carotid intima media thickness, echocardiographic examination, ECG recording, bioempedance meter analysis of body composition, pulmonary function test and various biochemical analysis. Result: Twenty nine percent of the population had hypertension, 12% had diabetes mellitus and 17% were smokers. Thyroid ultrasonography revealed that 29% of the cohort had goiter. Echocardiographic measurements showed that 39% of the participants had diastolic dysfunction. Comparison of males with females showed that men had significantly higher visceral fat, triglyceride, hemoglobin and CIMT whereas women had higher mean diastolic blood pressure, HDL and total cholesterol. Conclusion: According to the histories of patients, hypertension, diabetes mellitus and smoking were very frequent among Turkish adults. Among the objectively measured variables, diastolic dysfunction, visceral adiposity and goiter were strikingly high.

MELEN study: Rationale, methodology and basic results

PDF

___

1. WHO (2005) Preventing chronic diseases: a vital investment: WHO global report. http://www.who.int/chp/ chronic_disease_report/full_report.pdf.
2. Onat A: Risk factors and cardiovascular disease in Turkey. Atherosclerosis 2001;156:1-10.
3. Onat A, Uysal Ö, Hergenç G. Assessment of the cohort of the Turkish Risk Factor Study with Framingham risk function: an additional indicator of the high absolute coronary risk among Turks (in Turkish). Turkish Cardiol Sci Arch 2001; 29: 208–14.
4. Onat A (editor). TEKHARF 20 years. 1st edn. Logos Inc: Istanbul, 2011.
5. Erdoğan G, Erdoğan MF, Delange F, Sav H, Güllü S, Kamel N. Moderate to severe iodine deficiency in three endemic goitre areas from the Black Sea region and the capital of Turkey. Eur J Epidemiol 2000;16(12):1131-4.
6. Montauban van Swijndregt AD, De Lange EE, De Groot E, Ackerstaff RG. An in vivo evaluation of the reproducibility of intima-media thickness measurements of the carotid artery segments using B-mode ultrasound. Ultrasound Med Biol 1999;25:323-30.
7. Bayram F, Beyazyildiz A, Gökçe C, et al.The prevalence of iodine deficiency, serum thyroglobulin, anti-thyroglobulin and thyroid peroxidase antibody levels in the urban areas of Kayseri, Central Anatolia. Exp Clin Endocrinol Diabetes 2009;117(2):64-8. Epub 2009 Feb 4.
8. Gutekunst R, Smolarek H, Hasenpusch V, et al. Goiter epidemiology: Thyroid volume, iodine excretion, thyroglobulin and thyrotropin in Germany and Sweden. Acta Endocrinol 1986;112:494-501.
9. Henry WL, De Maria A, Framiak R, et al: Report of the American society of echocardiography committee on nomenclature and standards in two dimensional echocardiography. Circulation 1980; 62:212–7.
10. Genuth S, Alberti KG, Bennett P, et al. Follow-up report on the diagnosis of diabetes mellitus. Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 2003;26:3160-7
11. Grundy SM, Brewer HB, Cleeman JI, et al. Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation 2004;109:433-8
12. Onat A, Uyarel H, Hergenç G, et al. Determinants and definition of abdominal obesity as related to risk of diabetes, metabolic syndrome and coronary disease in Turkish men: a prospective cohort study. Atherosclerosis 2007: 191;182-90.
13. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Washington, DC: American Psychiatric Association; 1994.
14. Nagueh SF, Appleton CP, Gillebert TC, Marino PN, Oh JK, Smiseth OA, Waggoner AD, Flachskampf FA, Pellikka PA, Evangelisa A. Recommendations for the evaluation of left ventricular diastolic function by echocardiography. Eur J Echocardiogr. 2009;10:165-93.
15. Onat A, Türkmen S, Karabulut A, Yazıcı M, Can G, Sansoy V. Combined Hypercholesterolemia and Hypertension Among Turkish Adults: Prevalence and Prediction of Cardiovascular Disease Risk. Turkish Cardiol Sci Arch 2004;32:533-41
16. Altun B, Arıcı M, Nergizoğlu G, et al. Prevalence, awareness, treatment and control of hypertension in Turkey (the PatenT study) in 2003. J Hypertens 2005; 23:1817-23.
17. Oguz A. For the METSAR investigators. Metabolic syndrome prevalence in Turkish adults. XX. National Cardiology Congress, Antalya, Turkey. Cardiology Congress Abstract Book 2004.
18. Süleymanlar G, Utas C, Arinsoy T, et al. A populationbased survey of Chronic REnal Disease In Turkey--the CREDIT study. Nephrol Dial Transplant 2011;26:1862-71