Murat CAN, Taner BAYRAKTAROĞLU, Tacettin ÖRNEK, Gülay KOÇAK, Remzi ALTIN, Hulusi ATMACA, Erdem KOÇAK, Hatice BAKIRTAŞ

Insulin resistance and serum leptin levels in men with obstructive sleep apnea syndrome

Amaç: Bu çalışmanın amacı obstrüktif uyku apne sendromu (OUAS) olan hastalarda insülin rezistansı ve serum leptin seviyelerini incelemek ve OUAS olan hastaların vücut kitle indeksini (VCİ) kontrol grubuyla karşılaştırmaktır. Metod: Apne hipopne indeksi (AHİ)≥5 olan 28 hasta çalışmaya dahil edildi. Sağlıklı 32 birey kontrol grubu olarak kullanıldı. Çalışmaya katılan bireylerden glukoz, insülin ve leptin seviyelerini ölçmek için açlık durumunda venöz kan elde edildi. İnsülin rezistans indeksinde, hemostaz modeli analiz methodu (HOMA-IR) temel alındı. Bulgular: OUAS grubu ile kontrol grubu arasında serum leptin seviyeleri (kontrol grubu, 32.88 ± 24.22 ng/ml, OUAS grubu, 24.93 ± 25.84 ng/ml) ve HOMA-IR (kontrol grubu, 3.01 ± 1.81, OUAS grubu, 2.58 ± 1.21) açısından anlamlı bir fark yoktu. OUAS olan hastalarda insülin rezistansı ve plazma leptin konsantrasyonları AHİ’den bağımsızdı ve kontrol grubundan farklı değildi. Sonuç: İnsülin rezistansı ve plazma leptin konsantrasyonları sıklıkla VKİ ve obesitenin derecesiyle ilişkili olduğunu düşünüyoruz. Bu parametreler OUAS olan hastalarda AHİ ile ilişkili olmadığı gözükmektedr.

Obstrüktif uyku apne sendromu olan erkek hastalarda insülin rezistansı ve serum leptin seviyeleri

Aim: The aim of this study was to assess the insulin resistance and serum leptin levels in patients with obstructive sleep apnea syndrome (OSAS), and to compare body mass indexes (BMI) of OSAS patients with matched controls without OSAS. Method: Twenty eight patients having apnea-hypopnea index (AHI)≥5 included in the study. Thirty two healthy subjects assumed as a control group. Venous blood was obtained in the fasting state for the measurement of glucose, insulin and leptin levels. Insulin resistance index was based on the homeostasis model assesment method (HOMA-IR). Result: There was no significant difference in the serum leptin levels (control group, 32.88±24.22 ng/ml, OSAS group, 24.93±25.84 ng/ml) and HOMA-IR (control group, 3.01±1.81, OSAS group, 2.58±1.21) between control group and OSAS patients. Insulin resistance and circulating plasma leptin concentrations in OSAS patients were independent of the AHI and were not different from the control group. Conclusion: We concluded that insulin resistance and plasma leptin concentrations are mostly associated with the degree of obesity and BMI. Those parameters seem not to be related with the AHI in OSAS patients.

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