Effects of ginseng on antioxidant enzymes in rats fed cholesterol rich diet

Amaç: Bu çalışmada yüksek kolesterollü diyetle beslenen ratlarda ginsengin antioksidan enzimler üzerine etkilerinin belirlenmesi amaçlanmıştır.Gereç ve Yöntem: Çalışmada kullanılan hayvanlar kontrol, kolesterol ve kolesterol + ginseng grubu olarak üç eşit gruba ayrıldı. Kontrol grubu 40 gün süre ile standart rat yemi ile ad libitum olarak beslendi. Kolesterol grubu %5 kolesterol içeren yemle beslenirken, kolesterol + ginseng grubu ise %5 kolesterol ve 1 g/kg panax ginseng kök tozu içeren aynı yemle beslendi. Çalışmanın 40. gününde bütün gruplardaki hayvanlardan kan örnekleri alındı. Alınan kanların plazmalarında tiyobarbitürik asit reaktif ürünleri (TBARS), süperoksit dismutaz (SOD), glutatyon (GSH), glutatyon peroksidaz (GPx) ve katalaz (CAT) düzeyleri belirlendi.Bulgular: Çalışmada kolesterollü diyetle beslenen gruptaki hayvanlarda belirlenen GSH ve SOD düzeylerinin kontrol grubu değerleri ile karşılaştırıldığında anlamlı olarak azaldığı gözlenirken (P

Yüksek kolesterollü diyetle beslenen ratlarda ginsengin antioksidan enzimler üzerine etkileri.

Aim: In this study, it was aimed to investigate the effects of ginseng on antioxidant enzymes in rats fed cholesterol rich diet. Materials and Methods: Rats were equally divided into three groups: control group, cholesterol group and cholesterol + ginseng group. The control group had fed as ad libitum with a standard rat diet for 40 days. The cholesterol and cholesterol + ginseng groups had ad libitum access to the same diet containing 5% cholesterol powder and 5% cholesterol + 1 g/kg panax ginseng root powder, respectively, for 40 days. On the 40th day of the study, blood samples were taken from all animals in each group. In plasma samples, thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), glutathione (GSH), glutathione peroxidase (GPx) and catalase (CAT) levels were determined.Results: GSH and SOD levels significantly decreased with feeding high cholesterol diet compared to control group (P

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