Effect of single dose dexamethasone (0.1 mg/kg) on white blood cell counts and serum glucose levels in healthy ewes

Amaç: Araştırmanın öncelikli amacı sağlıklı koyunlara tek doz deksametazon (0.1 mg/kg, SC) uygulamasının akyuvar sayısı ve serum glikoz düzeyine etkisini belirlemektedir. Ay-rıca deksametazonun diğer bazı hemogram ve serum biyo-kimyasal parametrelere etkisi de değerlendirilmiştir. Gereç ve Yöntem: Araştırmada 8 adet sağlıklı Akkaraman koyuna 0.1 mg/kg (SC, tek doz) dozunda deksametazon uy-gulandı. Uygulamadan önce (0. saat, kontrol) ve sonraki 4, 8, 12, 24, 36, 48 ve 72. saatlerde kan örnekleri alındı. Akyuvar sayısı, alyuvar sayısı, platelet sayısı, hemogram ve hematok-rit değerleri kan hücresi sayım cihazında ölçülürken, serum glikoz, laktat dehidrogenaz, alkalin fosfataz, total bilirubin, alanin aminotransferaz, aspartat aminotransferaz, gamma glutamiltransferaz, total protein, albümin, kan üre nitrojen, kreatinin, kolesterol, trigliserit, yüksek yoğunluklu lipopro-tein ve düşük yoğunluklu lipoprotein düzeyleri otoanalizör-de ölçüldü. Bulgular: Kontrol (0. saat) zamanla karşılaştırıldığında, dek-sametazonun akyuvar sayısı ve serum glikoz düzeyini yük-selttiği (P

Koyunlara tek doz deksametazon (0.1 mg/kg) uygulamasının akyuvar sayısı ve serum glikoz düzeylerine etkisi.

Aim: Aim of this research was to determine that effect of single dose dexamethasone (0.1 mg/kg, SC) on the white blo-od cell counts and serum glucose levels in healthy ewes. In addition, effects of dexamethasone on the other hemogram and serum biochemical values were evaluated. Materials and Methods: Totally healthy 8 Akkaraman sheep were received with 0.1 mg/kg (SC, single dose) dexametha-sone. Blood samples were taken before (0. hour, control) and after treatments at 4, 8, 12, 24, 36, 48 and 72 hours. White blood cell, red blood cell, platelet, hematocrit and hemog-lobin levels were measured by hemocell counter, whereas serum glucose, lactate dehydrogenase, alkaline phosphata-se, total bilirubin, alanine aminotransferase, aspartate ami-notransferase,gammaglutamyltransferase,totalprotein,albumin, blood urea nitrogen, creatinine, cholesterol, trigl-yceride, high density lipoprotein and low density lipoprotein levels were determined by auto-analyzer. Results: Dexamethasone increased (P

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