Murat Kaan DURGUT, Onur CEYLAN, Ceylan CEYLAN, Merve İDER, Mahmut OK, Ferda SEVİNÇ, Alper ERTÜRK

Cryptosporidiosis ile doğal olarak enfekte olan neonatal buzağıların tedavisinde gamitromisinin klinik etkinliğinin değerlendirilmesi

Amaç: Bu çalışmada kriptosporidiozis ile doğal olarak enfekte olmuş neonatal buzağıların tedavisinde gamitromisinin klinik etkinliğinin belirlenmesi amaçlanmıştır. Gereç ve Yöntem: 5-20 günlük 20 diyareli neonatal buzağı oluşturdu. Kriptosporidiozis tanısı mikroskopik inceleme ve ELISA testi ile konuldu. Dışkıda gram başına 4 x 104 ile 15 x 106 arasında kriptosporidium ookisti görülen buzağılar çalışmaya dahil edildi. Hemogram ve kan gazları tedavinin başlangıcında ve tedaviden sonra ölçüldü. Buzağılara subkutan olarak tek doz 6 mg/ kg dozunda gamitromisin uygulandı. İlacın etkinliği, 5. güne kadar ishalin durumu, ookist saçılımı ve vücut durumunun değerlendirilmesi ile takip edildi. Bulgular: Beşinci günde, altı tane buzağı dışkısında ookist saptanmazken, 11 buzağı dışkısında ookist sayısı önemli oranda azaldı. Tedavinin başlangıcında ve tedaviden sonra kan değerlerinde istatistiksel olarak belirgin fark (p

Evaluation of clinical efficacy of gamithromycin in the treatment of naturally infectedneonatal calves with cryptosporidiosis

Aim: The purpose of this study was to investigate the clinical efficacy of gamithromycin in the treatment of naturally infected neonatal calves with cryptosporidiosis. Materials and Methods: 5-20 days old 20 diarrheic neonatal calves were used as material in this study. Diagnosis of cryptosporidiosis was made by microscopic examination and ELISA test. Calves shedding Cryptosporidium oocysts between 4 x 104 and 15 x 106 per gram in feces were included in the study. Hemogram and blood gases were measured at the beginning of the treatment and after the treatment. A single dose of 6 mg/kg body weight of gamithromycin was administered subcutaneously. Drug efficacy was assessed by evaluating the existence of diarrhea, oocyst shedding and body condition from day 1 to 5. Results: On 5th day, the medicated 6 calves had no oocysts, and number of oocysts in feces had been decreased in 11 calves on 5th day. Statistically significant difference (p

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