Köpeklerde Leptospirozisin Epidemiyolojik Değişimi
Köpek Leptospimzisi genellikle L. interrogans seravar icteı-ohaemorrhagiae ve seravar canicola tarafından oluşturulmaktadır.
Fakat son yıllarda Kuzey Amerika'da ve bazı Avntpa ülkelerinde pomona, grippotyphosa ve bratislava
serovadarının da infeksiyana sebep olduğu bildirilmektediı: Hastalık, zoonoz olup yüksek ateş, kusma, depresyon,
hemoraji, kanlı idrar ve dışkı, sarı/ık, hepatik ve renal yetmezlik, abort ve in fertilite ile seyreder ve ölümle sonuçlanabil
ir. Bu derlemede; köpeklerin bu önemli enfeksiyonunun epidemiyolojisi, klinik hastalık bulguları, klinik laboratuvar
· bulguları, klinik mikrobiyolojik tanısı, tedavisi ve eııfeksiyondan korunma hakkında bilgi verilmektedir.
"The Epidemiologic Changes of Canine Leptospirosis"
Leptospirosis in do gs is caıtsed by L. interrogans serovaı·s icterohaemorrhagiae and canicola in general, but with
other serovaı·s such as pomona, grippotyphosa, and bratislava couse elinical Leptospirosis in dogs in North America
and some European countries have been reported to due to ep idemiologic change. The disease is zoonotic and associated
with Jever, vomiting, depression, haemorrhage, bloodstained uı·ine and Jaeces, jaundice, hepatic and renal failure, abortion, infertility and death. In this ı·eview artiele; epidemiology, elinical sin gs, elinicallaboratory findings, elinical
microbiological diagnosis, treatment, and prevention of this important disease of do gs are presented.
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- ADIN CA, COWGILL LD (2000) .
Treatment and outcome of do gs with leptospirosis:
Etlik Veteriner Mikrobiyoloji Dergisi • Yil: 2003 Cilt 14 • Say1: 1-2
36 cases (1990-1998}. J Am Vet Med Assoc,
216,371-375.
- AP PEL MJ (1999). Forty yeaı-s of canine vaccination.
Adv Vet Med, 41,309-324.
- BEY RF, JOHNSON RC (1982). Leptospiral
vaccines in dogs: Immunogenicity of who/e eel/
and outer env~lope vaccines prepared in proteinfree
medium. Am] Vet Res, 43,831-834.
- BIRNBAUM N, BARR SC, CENTER SA,
SCHERNERHORN T, RANDOLPH NF,
SIMPSON KW (1998). Naturally acquired
leptospirosis in 3 6 do gs: serological and clinicopathological
features. J Smail Anim Pract, 39,
232-236.
- BO LIN CA (1996). Diagnosis ofleptospirosis: a
reemerging disase of companian animals. Sernin
Vet Med Surg (Smail Anim), 11, 166-171.
- BROWN CA, ROBERTS AW, MILLER
MA, DAVIS DA, BROWN SA, BOLIN
CA, JARECKI-BLACK J, GREENE CE,
MILLER-LIEEL D (1996). Leptospira intermgans
seı·ovar grippotyphosa infection in dogs. J
Am Vet Med Assoc, 209, 1265-1267.
- CAI HY, HORNEY G, KEY DW, OSUCH
MR, MAXIE MG (2002). Preliminary study
on dijfeı·entiation of Leptospira grippotyphosa
and Leptospira sejroe from other com mo n pathogenic
leptospiral serovars in canine urine by polymerase
chain reaction ass ay. J Vet Diagn Invest,
14, 164-168.
- CARMICHAEL LE (1999). Canine viı-al
vaccines at a tuming point-a personal perspective.
Adv Vet Med, 41,289-307.
- DUVAL D, GIGER U (1996). Vaccine-associated
immıme-ınediated hemolytic aneınia in the
dog.] Vet Intern Med, 10: 290-295.
- ELLIS WA (1986). Leptospirosis. J Smail
Anim Pract, 27, 683-692.
- 80-
- FAINE S, ADLER B, BOLIN C, PEROLAT
P (1999). Leptospira and Leptospirosis.
2nd ed., MediSci, Melbourne, Australia.
- HARKIN KR, GARTRELL CL (1996).
Canine leptospirosis in New ]ersey and
Michigan: 17 cases (1990-1995}. J Am Anim
Hosp Assoc, 32, 495-501.
- HARKIN KR, ROSHTO YM, SULUVAN
JT (2003). Clinical application of a polymerase
chain reaction assay for diagnosis of leptospirosis
in dogs.] Am Vet Med Assoc, 222, 1224-1229.
- HARKIN KR, ROSHTO YM, SULUVAN
JT, PURVIS TJ, CHENGAPPA MM
(2003). Comparison of polymerase chain reaction
assay, bacteriologic culture, and seralogic testing
in assessınent of prevalence of urinaıy shedding of
leptospiı·osis in dogs.] Am Vet Med Assoc, 222,
1230-1233.
- BARTMAN EG (1984). AnIgM-and IgGspecific
enzyme-linked immunosorbent assay
(ELISA) to detect anti-leptospiral iınmunoglobulins
in dogs. Zentbl Bakteriol, 257, 508-510.
- BARTMAN EG (1984). Epidemiological
aspects of canine leptospirosis in the Netherlands.
Zentbl Bakteriol Hyg A, 258, 350-359.
- BARTMAN EG, VAN HOUTEN M,
FRIK JF, VAN DER DONK JA (1984).
Humoral imınune response of dogs after vaccinatioıı
against leptospirosis measuı·ed by an IgM
·and IgG-specific ELISA. Vet Immunol
Immunopathol, 7, 245-254.
- BARTMAN EG, VAN HOUTEN M,
VAN DER DONK JA, FRIK JF (1984).
Seradiagnosis of canine leptospirosis by solidphase
enzyme-linked iınmunosorbent assay. Vet
Immunol Immunopathol, 7, 33-42.
- HARTSKEERL RA, SMITS HL, KORVER
H, GORIS MGA, TERPSTRA WJ
(2002). Handbook of Intmıatioııal Course on
Köpeklerde leptospirozis - KOCABIYlK
Laboratory Methods for the Diagnosis of
Leptospirosis. Royal Tropical Institute,
Amsterdam, the N etherlands.
- KALIN M, DEVAUX C, DIFRUSCIA R,
LEMAY S, HIGGINS R (1999). Three cases
of canine leptosoirosis in Quebec. Can Vet J, 40,
187-191.
- LEVETT PN (2001) . Leptospi1·osis. Clin
Microbiol Rev, 14,296-326.
- ÖZDEMİR V, DiKER KS (1999). Köpek
serumlarının leptospirozis yönünden mikroskopik
aglutinasyon testi ve ELISA ile incelenmesi.
Etlik Vet Mikrob Derg, 10, 1-17.
- PRESCOTT JF, MCEWEN B, TAYLOR},
WOODS JP, ABRAMS-OGG A, WILCOCK
B (2002) . Resurgeııce of leptospirosis in
dogs in Ontario: 1·ecent Jindings. Can Vet J, 43,
955-961.
- RIBOTTA M, FORTIN M, HIGGINS R,
BEAUDIN S (2000). Canine leptospirosis:
serology. Can Vet}, 41,494-495.
- RIBOTTA MJ, HIGGINS R, GOTTSCHALK
M, LALLIER R-· (2000).
Development of an indirect enzyme-linked
immunosorbent ass ay for the detection of leptospiral
antibodies in dogs. CanJ Vet Res, 64,32-37.
- SCANZIANI E, ORIGGI F, GIUSTIA.M,
IACCHIA G, VASINO A, PIROVANO G,
SCARPA P, TAGLIABUE S (2002).
Serological survey of leptospiral infection in kennelled
dogs in Italy. J Smail Anim Pract, 43,
154-157.
- STEGER-LIEB A, . GERBER B, NICOLET
J, GASCHEN .F'(199"9). An old disease
with a new Jace: ca~ ine leptospirosis does not los e
its relevance. Schweiz Arch Tierheilkd, 141,
499-507.
- UNAT EK, GÜRTÜRK S (1954). Türkiye'de
Leptospira canicola infeksiyonu. Türk Vet
Hekim Dern Derg, 24, 96-97.
- ÜLGEN M, ÇETİN C, ÖZDEMİR V,
BÜYÜKÇOBAN M (1997). Buna ilindeki
sokak köpekle1·inde leptospirozisin seroprevalansı.
Etlik Vet Mikrob Derg, 9, 108-114.
- WARD MP (2002). Seasonality of canine leptospirosis
in the United States and Canada and its
association with rainfall. Prev Vet Med, 56,
203-213.
- WATSON ADJ (1994). Leptospimsis in cats
and dogs. Aust Vet J, 71, 59-60.
- WEEKES CC, EVERARD CO R,
LEVETT PN (1997). Seroepidemiology of
canine leptospirosis on the isiand ofBarbados. Vet
Microbiol, 51, 215-222.