GESTASYONEL HİPERTANSİF BOZUKLUKLAR ile TROMBOSİT BELİRTEÇLERİNİN İLİŞKİSİ / THROMBOCYTE INDICES RELATION WITH GESTATIONAL HYPERTENSIVE DISORDERS

Çalışmanın amacı trombosit indeksleri, eritrosit dağılım genişliği (RDW) ve gestasyonel hipertansif bozukluklar arasındaki ilişkiyi değerlendirmektir. Çalışma 2009-2019 yılları arasında yapılan retrospektif kesitsel bir çalışmadır. Toplam 583 hamile kadın çalışmaya dahil edildi; 123 şiddetli preeklampsi (PE), 175 hafif PE, 73 gestasyonel hipertansiyon (GH), 41 kronik hipertansiyon ve 171 sağlıklı gebe (kontrol grubu). Verilerin yorumlanmasında Kolmogorov-Smirnov, ANOVA, Kruskal-Wallis ve Mann Whitney U testleri kullanılmıştır. İstatistiksel anlamlılık p <0.05 olduğunda kabul edildi. Ortalama yaş ve gebelik sayısı açısından beş grup arasında fark bulunmadı. Ortalama Trombosit Hacmi (MPV) şiddetli PE grubunda anlamlı derecede yüksek (p <0.001) bulundu. Hafif PE, GH, kronik hipertansiyon ve kontrol grupları arasında MPV değerleri anlamlı derecede farklı değildi (p = 0.116). Trombosit sayısı (PC) şiddetli PE grubunda anlamlı olarak düşük bulundu (p = 0.01). Hafif PE, GH, kronik hipertansiyon ve kontrol grupları arasında PC değerleri arasında anlamlı farlılık bulunmadı (p=0.110). RDW, şiddetli PE grubunda diğer gruplardan (p = 0.01), hafif PE grubunda GH, kronik hipertansiyon ve kontrol gruplarından (p = 0.01) anlamlı olarak daha yüksek bulundu. Gestasyonel hipertansiyon, kronik hipertansiyon ve kontrol grupları arasında RDW değerleri anlamlı derecede farklı bulunmadı. (p= 0.501). Trombosit dağılım genişliği (PDW) kontrol grubunda diğer gruplara göre anlamlı olarak düşük bulundu (p <0.001). Hafif PE, GH, kronik hipertansiyon ve şiddetli PE grupları arasında PDW değerleri arasında farklılık bulunmadı (p = 0.621). Nötrofil lenfosit oranı (NLR), hemoglobin, Trombosit ve Trombosit lenfosit oranı (PLR) gruplar arasında farklılık göstermedi. MPV, RDW, PDW, NLR, PC, Trombosit ve PLR değerleri GH ve kronik hipertansiyon grupları arasında farlılık göstermedi. Şiddetli PE'de MPV ve RDW daha yüksek ve PC daha düşük bulundu. Preeklempsi şiddeti arttıkça RDW düzeylerinde artış olmaktadır. Gestasyonel hipertansif hastalıklarda RDW seviyeleri sağlıklı gebelerden daha yüksek bulunmuştur.

Anahtar Kelimeler:

Preeklampsi, hipertansiyon, trombosit indeksleri, MPV, PDW, RDW, NLR

THROMBOCYTE INDICES RELATION WITH GESTATIONAL HYPERTENSIVE DISORDERS

The aim of this study to evaluate relationship between thrombocyte indices, Red cell distribution width (RDW) and gestational hypertensive disorders. This study is a retrospective cross sectional study performed between 2009 - 2019.Total 583 pregnant women were included in this study; 123 severe preeclampsia (PE), 175 mild-PE, 73 gestational hypertension (GH), 41 chronic hypertension and 171 healthy pregnant women (control group). Statistical Package for Social Science version 23.0 is used for statistical analysis. Kolmogorov-Smirnov, Anova, Kruskal-Wallis and Mann Whitney U tests are used for interpretation of data. Statistical significance is considered if p < 0.05. Mean age and number of pregancies were indifferent among five groups. Mean Platelet Volume (MPV) was significantly higher in severe-PE group (p<0.001) and insignificantly different among mild-PE, GH, chronic hypertension and control groups (p=0.116) . Platelet count (PC) was found significantly lower in severe-PE group (p=0.01) and found indifferent among mild-PE, GH, chronic hypertension and control groups (p=0.110). RDW was found significantly higher in severe-PE group than other groups (p=0.01)and significantly higher in mild-PE group than GH, chronic hypertension and control groups (p=0.01) but insignificantly different among GH, chronic hypertension and control groups (p=0.501). Platelet distribution width (PDW) was found significantly lower in control group than other groups (p<0.001) and found indifferent among mild-PE, GH, chronic hypertension and severe-PE groups (p=0.621). Neutrophil lymphocyte ratio (NLR), hemoglobin, Plateletcrit and Platelet lymphocyte ratio (PLR) were found unchanged among the groups. MPV, RDW, PDW, NLR, PC, Plateletcrit and PLR were indifferent among GH and chronic hypertension groups. MPV and RDW were found higher and PC was found lower in severe-PE. RDW levels elevation was found higher in accordance with the severity of preeclampsia. PDW was found higher in gestational hypertensive disorders than healthy pregnant women.

Keywords:

Preeclampsia, hypertension, thrombocyte indices, MPV, PDW, RDW, NLR,

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