ATEROJENİK İNDEX İLE SABAH KAN BASINCI DALGALANMASI ARASINDAKİ İLİŞKİ

Giriş: Sabah Kan Basıncı Dalgalanması (SKBD) fenomeni, sabah kan basıncında (KB) belirgin bir artış olarak tanımlanır. SKBD, kardiyovasküler hastalık (KVH) riskinde artışa ve tüm nedenlere bağlı ölümlere neden olur. Plazma aterojenite indeksi (PAİ), koroner ateroskleroz ve kardiyovasküler (KV) hastalık riskini tahmin etmek için kullanılır. Bu çalışmada SKBD ve PAİ arasındaki ilişkiyi incelemeyi amaçladık. Yöntemler: Çalışmamıza ambulatuvar KB izlemesi olan 296 ardışık katılımcı dahil edildi. Hasta bilgileri hastane veri tabanından geriye dönük tarama yapılarak elde edildi. Elde edilen PAİ skoruna göre hastalar 3 gruba ayrıldı. SKBD ve PAİ risk grupları arasındaki ilişki incelenmiştir. Bulgular: PAİ değeri hesaplandıktan sonra risk sınıflandırması yapıldı. Risk sınıflandırmasına göre; <0,11 düşük risk, 0,11-0,21 orta risk ve >0,21 yüksek risk. PAİ risk grupları ve SKBD değerleri karşılaştırıldı. SKBD ile PAİ arasında korelasyon saptandı. SKBD ile ilişkili parametreleri belirlemek için yapılan çoklu regresyon analizinde; yüksek risk grubunda yaş (p= 0,011), vücut kitle indeksi (VKİ) (p= 0,001), lenfosit düzeyi (p= 0,002), sigara içme (p= 0,024), erkek cinsiyet (p= 0,002), atriyal fibrilasyon (AF) (p= 0,018) ilişkili bulundu. Sonuç: Çalışmamızın sonuçları artmış PAİ ve SKBD'nin bağımsız olarak ilişkili olduğunu göstermektedir. Yüksek PAİ puanı, artmış SKBD'yi gösterir. Ancak KVH açısından yüksek risk taşıyan hastalarda SKBD'nin bir tedavi hedefi olup olmayacağının belirlenmesi için gelişmiş çalışmalara ihtiyaç vardır.

Anahtar Kelimeler:

morning surge blood pressure, plasma atherogenicity index, cardiovascular diseases

THE RELATIONSHIP OF MORNING SURGE in BLOOD PRESSURE and ATHEROGENIC INDEX

Introduction: The Morning Surge Blood Pressure (MSBP) phenomenon is described as a marker an increase in morning blood pressure (BP). MSBP causes an increased risk of cardiovascular disease (CVD) and death from all causes. The atherogenic index of plasma (AIP) is used to predict the risk of coronary atherosclerosis and cardiovascular (CV) disease. In this study, we aimed to investigate the relationship between MSBP and AIP. Methods: Our study included 296 consecutive participants with ambulatory BP monitoring. Patient data were obtained by retrospective scanning from the hospital database. The patients were divided into 3 groups according to the obtained AIP score. The relationship between MBPS and AIP risk groups was examined. Results: After calculating the AIP value, risk classification was made. According to the risk classification; <0.11 low risk, 0.11-0.21 medium risk, and >0.21 high risk. AIP risk groups and MBPS values were compared. In the multiple regression analysis to determine the parameters associated with MSBP; age (p= 0.011), body mass index (BMI) (p= 0.001), lymphocyte level (p= 0.002), smoking (p= 0.024), male gender (p= 0.002), atrial fibrillation (AF) (p= 0.018) in the high- risk group. Conclusion: Our retrospective study showed that increased AIP and MSBP are independently associated. A high AIP score indicates increased MSBP. However, prospective studies with large participation are needed to determine whether MSBP will be a treatment target in patients at high risk for CVD.

Keywords:

morning surge blood pressure, plasma atherogenicity index, cardiovascular diseases,

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