SARS-COV-2 VE İNFLUENZA KOENFEKTE HASTADA İNVAZİF TRİCHOSPORON ENFEKSİYONU: BİR OLGU SUNUMU

Trichosporon türleri, sistemik veya mukoza ile ilişkili ya da beyaz piedrayı da içine alan yüzeyel enfeksiyonlara neden olabileceği gibi invazif fungal enfeksiyonlara da neden olabilir. Özellikle hematolojik maligniteleri ve solid organ tümörleri olan veya transplant alıcısı immünosüprese hastalarda fırsatçı bir invazif enfeksiyon etkeni olabilirler. Trichosporon türlerine bağlı gelişen invazif enfeksiyonlarda son yıllarda artış gözlenmiştir.Trikosporonozlu hastaların tedavisi, kullanılan antifungal ajanlar hakkında etkene yönelik sınırlı veri nedeniyle sorun teşkil etmektedir. Bu bildiride COVID-19+İnfluenza nedeniyle uzun süreli yoğun bakım yatış sonrası gelişen invaziv trikosporonoz enfeksiyonu sonucu mortal seyreden bir olgu sunulmuştur.

Anahtar Kelimeler:

Trichosporon spp, COVID-19, İnfluenza

INVASIVE TRICHOSPORON INFECTION IN A SARS-COV-2 AND INFLUENZA COINFECTED PATIENT: A CASE REPORT

Trichosporon species can cause systemic or mucous-related or superficial infections including white piedra as well as invasive fungal infections. They can be an opportunistic invasive infectious agent, especially in immunosuppressed patients with hematological malignancies and solid organ tumors or transplant recipients. Invasive infections due to Trichosporon species have increased in recent years. The treatment of patients with trichosporonosis poses a problem due to limited data on the antifungal agents used. In this report, a case of mortality due to invasive trichosporonosis infection developed after a long-term hospitalization in intensive care unit due to COVID-19 + Influenza is presented.

Keywords:

Trichosporon spp, COVID-19, Influenza,

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1. Cafarchia C, Romito D, Coccioli C, et al. Phospholipase activity of yeasts from wild birds and possible implications for human disease. Med Mycol. 2008;46:429-34.
2. Fuentefria AM, Suh SO, Landell MF, et al. Trichosporon insectorum sp. nov., a new anamorphic basidiomycetous killer yeast. Mycol Res. 2008;12:93-9.
3. Guého E, de Hoog GS, Smith MT. Neotypification of the genus Trichosporon. Antonie Van Leeuwenhoek. 1992;61:285-8.
4. Haupt HM, Merz WG, Beschorner WE, et al. Colonization and infection with Trichosporon species in the immunosuppressed host. J Infect Dis. 1983;147:199-203.
5. Lussier N, Laverdière M, Delorme J, et al. Trichosporon beigelii funguria in renal transplant recipients. Clin Infect Dis. 2000;31:1299-301.
6. Sugita T, Kikuchi K, Makimura K, et al. Trichosporon species isolated from guano samples obtained from bat-inhabited caves in Japan. Appl Environ Microbiol. 2005;71:7626-9.
7. Walsh TJ. Role of surveillance cultures in prevention and treatment of fungal infections. NCI Monogr. 1990;9:43-5. 8. Walsh TJ, Groll A, Hiemenz J, et al. Infections due to emerging and uncommon medically important fungal pathogens. Clin Microbiol Infect. 2004;10: 44–66.
9. Vincent J-L, Rello J, Marshall J, et al. International study of the prevalence and outcomes of infection in intensive care units. JAMA. 2009; 302: 2323-9.
10. Colombo AL, Padovan AC, Chaves GM. Current knowledge of Trichosporon spp. and trichosporonosis. Clin Microbiol Rev 2011; 24: 682-700.
11. Kalkanci A, Sugita T, Arikan S. Molecular identifi cation, genotyping, and drug susceptibility of the basidiomycetous yeast pathogen Trichosporon isolated from Turkish patients. Med Mycol 2010; 48: 141-6.
12. Girmenia C, Pagano L, Martino B, et al; GIMEMA Infection Program. Invasive infections caused by Trichosporon species and Geotrichum capitatum in patients with hematological malignancies: a retrospective multicenter study from Italy and review of the literature. J Clin Microbiol 2005; 43: 1818-28.
13. Ruan SY, Chien JY, Hsueh PR. Invasive trichosporonosis caused by Trichosporon asahii and other unusual Trichosporon species at a medical center in Taiwan. Clin Infect Dis 2009; 49: e11-7.
14. Bayramoglu G, Sonmez M, Tosun I, et al. Breakthrough Trichosporon asahii fungemia in neutropenic patient with acute leukemia while receiving caspofungin. Infection 2008; 36: 68-70.
15. Chagas-Neto TC, Chaves GM, Melo AS, et al. Bloodstream infections due to Trichosporon spp.: species distribution, Trichosporon asahii genotypes determined on the basis of ribosomal DNA intergenic spacer 1 sequencing, and antifungal susceptibility testing. J Clin Microbiol. 2009;47:1074-81.
16. Basiri K, Meidani M, Rezaie F, et al. A rare case of Trichosporon brain abscess, successfully treated with surgical excision and antifungal agents. Neurol Neurochir Pol 2012; 46: 92-5.
17. Watson KC, Kallichurum S. Brain abscess due to Trichosporon cutaneum. J Med Microbiol. 1970;3:191-3.
18. Manzella JP, Berman IJ, Kukrika MD. Trichosporon beigelii fungemia and cutaneous dissemination. Arch Dermatol. 1982;118:343-5.
19. Reinhart HH, Urbanski DM, Harrington SD, et al. Prosthetic valve endocarditis caused by Trichosporon beigelii. Am J Med. 1988;84:355-8.
20. Lopes JO, Alves SH, Klock C, et al. Trichosporon inkin peritonitis during continuous ambulatory peritoneal dialysis with bibliography review. Mycopathologia. 1997;139:15-8.
21. Moretti-Branchini ML, Fukushima K, Schreiber AZ, et al. Trichosporon species infection in bone marrow transplanted patients. Diagn Microbiol Infect Dis. 2001;39:161-4.
22. Ruan SY, Chien JY, Hsueh PR. Invasive trichosporonosis caused by Trichosporon asahii and other unusual Trichosporon species at a medical center in Taiwan. Clin Infect Dis. 2009;49:e11-e7.
23. Suzuki K, Nakase K, Kyo T, et al. Fatal Trichosporon fungemia in patients with hematologic malignancies. Eur J Haematol. 2010;84:441-7.