T lenfositler gelişimi, fonksiyonları ve histokimyasal özellikleri

Kemik iliğinde embriyonal pluripotent köken hücrelerden (hemasitoblast) farklılaşan pre-T lenfositler (pre-T hücreleri) umusun korteksine göçerler. Timik kortekste, hücre membranlarında TCR (T hücre antijen reseptörü) ve CD (Yüzey farklılaşma antijenleri) gibi spesifik yüzey moleküllerinin kazanılması ile birlikte immünolojik fonksiyonları yerine getirebilen immun yetenekli T lenfositler oluşur. İmmun yetenekli T lenfositler, antijenlerle etkileşimleri sonucunda aktive olarak len-foblastlara dönüşürler. Lenfoblastların prolifere ve diferensiye olması ile sitotoksik, yardımcı, baskılayıcı ve bellek T lenfosit alt grupları meydana gelir. Bu derlemede, T lenfositlerin gelişimi, fonksiyonları ve histokimyasal özelliklerine yönelik bilgiler verildi.

Development, functions and histochemical properties of T lymphocytes

T lymphocytes (T cells) are differentiated from embrional pluripotent stem cells in bone marrow in that they migrate to the thymic cortex where they become immunocompetent similar to TCR and CD in expressing their specific cell membranes. These molecules permit them to perform their immunological functions. Immunocompetent T lymphocytes that have been activated by interaction with an antigen also transform into lymphoblasts that proliferative and differantiate into cytotoxic, helper, suppressor and memory which is subsets of T lymphocytes. In this review, some information was given about development, functions and histochemical properties of T lymphocytes.

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