Doğan ATAN, Emre APAYDIN, Kürşat Murat ÖZCAN, Hüseyin DERE

Kronik effüzyonlu otit tanısında yeni tanısal belirteçler: Nötrofil lenfosit oranı ve trombosit lenfosit oranı

Kronik effüzyonlu otit tanısında yeni tanısalbelirteçler: Nötrofil lenfosit oranı ve trombosit lenfosit oranı Amaç: Enflamasyon, kronik effüzyonlu otit (KEOM) etyolojisindeönemli bir yere sahiptir. Neutrophil to lymphocyte ratio (NLR) ve platelet to lymphocyte ratio (PLR) enflamasyonu gösteren ve bütün hekimlerin hesaplayabileceği basit, ucuz testlerdir. Bu çalıflmada KEOM ile NLR ve PLR değerleri arasındaki iliflkiyi ortaya koymayıamaçladık. Yöntem:Çalıflma KEOM tanısı konmufl olan 77 hastadan oluflan çocuk hasta grubu ile yafl, cinsiyet ve demografik özellikleri hasta grubuile uyumlu 62 sağlıklı çocuktan oluflan kontrol grubu ile yapıldı. Hasta ve kontrol grubu, NLR ve PLR değerleri açısından istatistiksel olarak karflılafltırıldı. Bulgular:Hasta grubunda NLR değeri ortalaması 1.43±0.54, kontrolgrubunda NLR ortalama değeri 1.16±0.51 olarak bulundu (p

New diagnostic indicators in chronic otitis media with effusion: neutrophil to lymphocyte ratio and thrombocyte lymphocyte ratio

Objective:Inflammation has an important place in chronic otitis mediawith effusion (COME) etiology. Neutrophil to lymphocyte ratio (NLR)and platelet to lymphocyte ratio (PLR) are simple and cheap tests thatshow inflammation and can be calculated by all physicians. In our study,we aimed to investigate the relationship between COME and NLR andPLR parameters. Methods:The study was performed with the pediatric patient groupconsisting of 77 patients who got diagnosis of COME and the controlgroup consisting of 62 healthy children whose age, gender and demographical characteristics were concordant with the patient group. Thepatient and control groups were compared statistically in terms of NLRand PLR values. Results: Mean neutrophil to lymphocyte ratio value was found as1.43±0.54 in the patient group and as 1.16±0.51 in the control group(p<0.001). Mean PLR value was found as 113.78±35.78 in the patientgroup and as 103.61±32.32 in the control group (p= 0.084).Conclusion:Neutrophil to lymphocyte ratio and PLR values were highin COME. It was shown for the first time that NLR can be used as adiagnostic parameter in children with COME.

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1. de Miguel Martinez I, Macias AR. Serous otitis media in children: implication of Alloiococcus otitidis. Otol Neurotol 2008; 29:526-30.
2. Holder RC, Kirse DJ, Evans AK, et al. One third of middle ear effusions from children undergoing tympanostomy tube placement had mult iple bacterial pathogens. BMC Pediatr 2012;12: 87.
3. Peitersen E. The natural history of Bell's palsy. Am J Otol 1982; 4:107-11.
4. Yilmaz M, Tarakcioglu M, Bayazit N, Bayazit YA, Namiduru M, Kanlikama M. Serum cytokine levels in Bell's palsy. J Neurol Sci 2002;197:69-72.
5. Somuk BT, Soyal>ç H, Koc S, Gürbüzler L, Do¤ru S, Eyibilen A. Mean platelet volume as an inflammatory marker of chronic otitis media with effusion. Int J Pediatr Otorhinolaryngol 2014; 78:1958-60.
6. Rushton HC, Tong MC, Yue V, Wormald PJ, van Hasselt CA. Prevalence of otitis media with effusion in multicultural schools in Hong Kong. J Laryngol Otol 1997;111:804-6.
7. Holmquist J, Al Fadala S, Qattan Y. Prevalence of secretory otitis media among school children in Kuwait. J Laryngol Otol 1987;101:116-9.
8. Erdivanli OC, Coskun ZO, Kazikdas KC, Demirci M. Prevalence of otitis media with effusion among primary school children in Eastern Black Sea, in Turkey and the effect of smoking in the development of otitis media with effusion. Indian J Otolaryngol Head Neck Surg 2012;64:17-21.
9. Yellon RF, Leonard G, Marucha PT, et al. Characterization of cytokines present in middle ear effusions. Laryngoscope 1991;101:165-9.
10. Smirnova MG, Kiselev SL, Gnuchev NV, Birchall JP, Pearson JP. Role of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion. Eur Cytokine Netw 2002;13:161-72.
11. Bhat T, Teli S, Rijal J, et al. Neutrophil to lymphocyte ratio and cardiovascular diseases: a review. Expert Rev Cardiovasc Ther 2013;11:55-9.
12. Ulu S, Ulu MS, Bucak A, Ahsen A, Yucedag F, Aycicek A. Neutrophil-to-lymphocyte ratio as a new, quick, and reliable indicator for predicting diagnosis and prognosis of idiopathic sudden sensorineural hearing loss. Otol Neurotol 2013;34:1400-4.
13. Azab B, Shah N, Akerman M, McGinn Jr JT. Value of platelet/lymphocyte ratio as a predictor of all-cause mortality after non-ST-elevation myocardial infarction. J Thromb Thrombolysis 2012;34:326-34.