Pulmoner blastom

Pulmoner Blastom (PB), malign mezenkimal stromaya ve epitelyal komponente sahiptir. Bu çalışmada, PB'lu iki olguyu irdeledik. Balgamda ARB pozitifliği olan ve medikal tedaviye rağmen toraks tomografisinde (TxBt) sağ akciğer üst lobda progrese kitle görülen hastanın, kitleden çalışılan frozen sonucu adenokarsinom gelmesi üzerine lobektomi yapıldı. Patoloji sonucu PB olarak geldi. İkinci olgunun TxBt' sinde sağ akciğer üst lobda düzgün sınırlı 3.5 cm çapında kitleye rastlanmıştır. Florodeoksiglukoz-pozitron emisyon tomografisi/bilgisayarlı tomografisinde (FDG-PET/BT) kitlenin SUV max değeri 7.8 idi. Frozen sonucu yine adenokarsinom geldi. Lobektomi yapıldı. Patoloji raporu PB olarak geldi. PB'un kesin tedavi seçeneği cerrahi rezeksiyondur. Her iki olgu postoperatif 1. yılda olup tümör rekürrensi yoktur.

Pulmonary blastoma

Pulmonary blastoma (PB) has both malignant mesenchymal stroma and an epithelial component. Two cases of PB are presented. The first case had ARB positive sputum samples with a progresive right upper lung mass in thorax computed tomography (TxCT), despite medical therapy. The frozen section result was adenocarcinoma. Lobectomy was performed. The pathological result was PB. The second case had a 3.5 cm right upper lung mass in TxCT with a 7.8 SUV max in fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT). The frozen section result was adenocarcinoma. A lobectomy was performed. The pathological result was PB. A surgical resection is the only curative option for PB. Both cases are in the postoperative first year without any tumor recurrence.

___

  • 1. Barnard WG. Embryoma of Lung. Thorax. 1952;7(4):299-301.
  • 2. Spencer H. Pulmonary blastomas. J Pathol Bacteriol. 1961;82:161-165.
  • 3. Larsen H, Sorensen JB. Resection and adjuvant chemotherapy of pulmonary blastoma. A case report. Cancer. 1996;78(3):569.
  • 4. Kradin RL, Young RH, Dickersin GR, Kirkham SE, Mark EJ. Pulmonary blastoma with argyrophil cells and lacking sarcomatous features (pulmonary endodermai tumor resembling fetal lung). Am J Surg Pathol. 1982;6(2): 165-72
  • 5. Brambilla E, Travis WD, Colby TV, et al. The new World Health Organization classification of lung tumors. Eur Respir J 2001;18:1059-68.
  • 6. Koss MN, Hochholzer L, O'Leary T. Pulmonary blastomas. Cancer. 1991 ;67(9):2368-81.
  • 7. Chin NK, Lee CN, Lee YS, et al. Pulmonary blastoma in an adult presenting as a chronic loculated effusion: A diagnostic problem. Thorax 1994;49:838-9.
  • 8. Rossi G, Cavazza A, Sturm N, et al. Pulmonary carcinoma with pleomorphic, sarcomatoid, or sarcomatous elements: A clinicopathologic and immunohistochemical study of 75 cases. Am J Surg Pathol 2003;27:311-24.
  • 9. Force S, Patterson GA. Clinical-pathologic conference in general thoracic surgery pulmonary blastoma. J Thoracic Cardiovascular Surg 2003;126:1250-47.
  • 10. Yu L, Li X, Yang W. Pulmonary blastoma metastatic to the ovary. Int J Gynecol Pathol. 2009;28(1):59-62
  • 11. Corapçioğlu F, Liman T, Aksu G, Inan N, Deveci M, Gürbüz Y, Topçu S. A case report with type II pleuropulmonary blastoma: successful treatment with surgery and chemotherapy. Turk J Pediatr. 2009;51(1):78-81.
Ege Tıp Dergisi-Cover
  • ISSN: 1016-9113
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 1962
  • Yayıncı: Ersin HACIOĞLU