Polikistik over sendromu tanısı konmuş 89 hastanın biyokimyasal, hormonal kan parametrelerinin ve klinik bulgularının incelenmesi

Amaç: Polikistik over sendromlu (PKOS) hastaların klinik özellikleri ve metabolik değişiklikler açısından incelenmesi. Yöntem ve Gereç: Ege Üniversitesi Kadın Hastalıkları ve Doğum polikliniğine Ağustos 2007 ve Eylül 2010 yılları içinde başvurmuş 89 PKOS tanısı konmuş hastayı retrospektif olarak taradık. Hastalara nasıl tanı konduğu, hastaların hangi şikayetlerle polikliniğe başvurdukları, vucut kitle indeksleri, Homeostatic Model Assesment (HOMA) indeksine göre insulin direnci olup olmadığı, kan lipid ve hormon profilleri incelendi. Bulgular: PKOS sendromlu hastaların ortalama yaşı 24,0±5,2; ortalama vucut kitle indeksi 24,1 ±4,4 kg / boy (m2) olarak saptandı. Hastaların %34'ünde HOMA 'ya flöre insulin direnci (n=31) saptandı. Hastaların en sık başvuru nedeni adet düzensizliği idi. Insulin direnci olan hastalardaki kan lipid düzeyleri incelendiğinde yüksek dansiteli lipoprotein (HDL) ve kolesterol düzeylerinde insülin direnci olmayanlara (n=58) göre istatistiksel olarak anlamlılık saptanmazken (p=0,69;p=0,14), düşük dansiteli lipoprotein (LDL) ve trigliserid düzeyleri insulin direnci olan grupta istatistiki olarak yüksek saptandı (p=0,005; p=0,01). Tüm hastalarda prolaktin ve tiroid stimulan hormon düzeylerine baktığımızda sırasıyla %17 ve %8 hastada yüksek saptandı. Sonuç: Polikistik over sendromu vucutta metabolik değişikliklere yol açarak hastalarda jinekolojik şikayetlere yol açabilir. Hastalar tüm hayat boyunca karşılaşılabilecek riskler açısından iyi bilgilendirilmeli ve takip altında tutulmalıdır.

The assessment of biochemical, hormonal blood parameters and clinical symptoms of 89 polycystic ovarian syndrome patients

Aim: Our aim was to investigate the metabolic parameters and clinic symptoms of polycystic ovarian syndrome (PCOS) patients. Material and Methods: We retrospectively reviewed 89 PCOS patients who were admitted to the Ege University Gynecology polyclinic between August 2007 and September 2010. Patients charecteristics, their complaints, ultrasonographic examination, biochemical and hormonal parameters were evaluated. Results: The mean age of PCOS patients and mean body mass index were 24,0±5,2 and 24,1 ±4,4 kg / m2 respectively. Insulin resistance was established due to Homeostatic Model Assesment HOMA index and 34% of the patients had insulin resistance (n=31). The most common complaint of patients was nonregular menstruation cycles. When we compared the non insulin resistant group with insulin resistant in terms of cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL) and triglyceride, HDL and cholesterol levels were not considered significantly high (p=0,69;p=0,14) while an increased low density lipoprotein and triglyceride levels were found to be significantly (p=0,005; p=0,01 low). Increased Thyroid stimulating hormone and prolactin hormone levels were found in 17% and 8% patients respectively. Conclusion: Polycystic ovarian syndrome may cause gynecologic complaints by the way of changing metabolic parameters. All PCOS patients should be followed regularly and should be informed in terms of risks that can be encountered during lifetime.

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Ege Tıp Dergisi-Cover
  • ISSN: 1016-9113
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 1962
  • Yayıncı: Ersin HACIOĞLU