Melazmada glikolik asit ve glikolik asit / topikal leke açıcı tedavi sonuçları: Retrospektif bir değerlendirme

Amaç: Bu çalışmanın amacı, melazma hastalarının demografik verilerinin ve sadece glikolik asit (GA) veya GA + topikal leke açıcı kombinasyon tedavisine yanıtlarının incelenmesidir. Gereç ve Yöntem: 2005-2009 tarihleri arasında kliniğimize melazma nedeniyle başvuran 200 hasta retrospektif olarak incelendi. Hastalar, sadece GA ile kimyasal soyma (Grup I), GA kimyasal soyma ile birlikte topikal leke açıcı tedavi (Grup II) ve tek başına topikal leke açıcı tedavi (Grup III) uygulanan üç gruba ayrıldı. Hastaların tedavi öncesi ve sonrası fotoğraflarının değerlendirilmesi ile Melazma Alan Şiddet İndeksi (MAŞİ) ilk ve son değerleri hesaplandı. Bulgular: Hastaların yaş ortalaması 37.71±6.97 idi. MAŞİ ilk değerleri 1.4-20.6 (7.64±3.82), MAŞİ son değerleri ise 0.6-20 (4.62±3.30) arasındaydı. 41 hasta (%20.5) Grup I, 100 hasta (%50) Grup II ve 47 hasta (%23.5) Grup III’de bulunmaktaydı. MAŞİ tedavi öncesi ve sonu değerleri (Grup I ve Grup II) arasındaki fark ayrı ayrı değerlendirildiğinde her iki grup için istatistiksel olarak anlamlıydı (p0.05). Sonuç: Bu çalışmada GA’nın hem tek başına kullanımında hem de topikal tedavi ile kombinasyonunda MAŞİ’de anlamlı azalma gözlenmiştir. Ancak bu iki tedavi modeli arasında MAŞİ’de azalma oranları açısından anlamlı fark saptanmamıştır.

Treatment results of glycolic acid and glycolic acid / topical lightening therapy in melasma: A retropective analysis

Introduction: The objective of this study is to examine the demographic properties of the melasma patients and the treatment response to only glycolic acid (GA) or GA + topical melasma skin lightening treatment. Materials and Methods: Between 2005 and 2009, 200 patients attending our clinic due to melasma were retrospectively analyzed. The patients were divided into three groups: Only chemical peeling with GA (Group I), GA chemical peeling with topical treatment (Group II) and only topical treatment (Group III). Pretreatment and posttreatment MASI (Melasma Area and Severity Index) scores were calculated with the assessment of the patient’s photographs. Results: The mean age of the patients was 37.71±6.97 years. Pretreatment MASI scores were between 1.4-20.6 (7.64±3.82), MASI last scores were between 0.6-20 (4.62±3.30). There were 41 patients (20.5%) in Group I, 100 patients (50%) in Group II, 47 patients (23.5%) in Group III. When the difference between MASI first and last scores were evaluated separately (Group I and Group II), a statistically significant difference was found in both in two groups (p<0.05). Although the difference between MASI first and last scores in two groups were compared with each other, it was not found to be statistically significant (p>0.05). Conclusion: In this study, both in the usage of GA alone and combination with topical treatments, MASI was found to decrease significantly. However, there was no statistical difference in the proportion of the decrease of MASI between these two treatment modality.

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