Evaluation of cognitive functions of the children with epilepsy treated with carbamazepine

Bu çalışmanın amacı karbamazepin alan hastalarda bilişsel fonksiyonların araştırılması ve karbamazepinin nöbet kontrolü ve tiroid fonksiyonları üzerine olan etkilerinin saptanmasıdır Çalışma primer idyopatik epilepsili 30 hasta üzerinde gerçekleştirilmiştir. Hastaların bilişsel fonksiyonları Wechsler Çocuk Zeka ölçeği (WISC-R) ile değerlendirilmiştir. Çalışma süresi boyunca hastaların total IQ skorları normal sınırlar içinde kalırken aritmetik ve resim düzenleme alt testlerinin 12. aydaki puanlarının tedavi öhcesi ve 6. aya göre ve parça birleştirme alt testinin 6. ve 12. aydaki puanlarının tedavi öncesine göre anlamlı olarak azaldığı saptanmıştır. Serum T4, serbest T4 ve serbest T3 değerierinin tedavinin 6. ve 12. ayındaki değerlerinin tedavi öncesi değerlerine göre belirgin olarak azaldığı tesbit edilmiştir. Serum serbest T4 -düzeyinde 6. ayda gözlenen azalma ile parça birleştirme alt test puan ı arasında ve serum serbest 73 düzeyinde 12. ayda gözlenen azalma ile şifre çözme alt test puanı arasında negatif ilişki saptanmıştır. Çalışmamızın sonuçları karbamazepin alan epileptik çocuklara eksik oldukları alanları desteklemek amacıyla izlem sırasında WISC-R alt testlerinin uygulanmasının gerekliliğini düşündürmüştür.

Anahtar Kelimeler:

Epilepsi, Karbamazepin, Çocuk, Kavrama yeteneği, Psikolojik testler

Karbamazepin tedavisi alan epilepsili çocukların bilişsel fonksiyonlarının değerlendirilmesi

The aim of this study is to investigate the cognitive functions of patients who received carbamazepine and to determine the effect of carbamazepine on seizure control and thyroid functions. The study was performed on 30 children with primary idiopathic epilepsy. The cognitive functions of the patients were evaluated according to Wechsler Intelligence Scale for Children-Revised. While total IQ scores of the patients remained in normal ranges during the study période, quotients for arithmetic and picture arrangement subtests were found to be significantly decreased by the 12th month when compared with pretreatment and eh month scores and quotients for object assembly subtest by the 6* and 12?" months when compared with the pretreatment score. The treatment led considerable decrease in serum T4, FT4 and FT3 levels at the o"1 and 12? months when compared with the pretreatment values. There was a significant correlation between the decrease in serum FT4 level at the 607 month and object assembly and also between the decrease in serum FT3 level at 12 month and decode subtest quotients. Our results suggest that epileptic children receiving carbamazepine have to be examined with WISC-R subtests during the follow-up to support the deficient subjects.

Keywords:

Epilepsy, Carbamazepine, Child, Cognition, Psychological Tests,

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