Koroner Arter Hastalığının Öngördürücüleri Olarak Trigliserid Glikoz İndeksi ve Trigliserid / HDL Oranı
Amaç: Trigliserid / yüksek yoğunluklu lipoprotein kolesterol oranı (TG / HDL-C) ve trigliserid-glikoz (TyG) indeksi basit, güvenilir tarama yöntemleridir. TyG indeksinin kardiyovasküler hastalıklarda mortaliteyi öngördüğü ve TG / HDL-C oranının koroner arter hastalığının (KAH) ciddiyetini öngördüğü gösterilmiştir. Koroner arter hastalığı ciddiyetini gösteren SYNTAX skoru ile TyG indeksi ve TG / HDL-C oranı arasındaki ilişkiyi tanımlamak için bir çalışma planladık. Gereç ve Yöntemler: Bu çalışmada koroner anjiyografi yapılan toplam 408 hasta değerlendirildi. TyG indeksi, TG / HDL-C oranı ve SYNTAX skorları hesaplandı. Hastalar tanılarına ve SYNTAX puanlarına göre gruplandırıldı. TyG indeksi, TG / HDL-C oranı ve SYNTAX skor arası ilişki incelendi. Bulgular: TyG indeksi ile KAH varlığı arasında anlamlı bir ilişki vardır (p
Triglyceride Glucose Index and The Triglyceride/HDL Ratio as Predictors of Coronary Artery Disease
Aim: Triglyceride to high density lipoprotein cholesterol (TG/HDL-C) ratio and triglyceride-glucose (TyG) index are simple, reliable screening methods. It has been shown that the TyG index predicts mortality in cardiovascular diseases and the TG/HDL-C ratio predicts the severity of coronary artery disease (CAD). We planned a study to define the relationship between the SYNTAX score, which indicates the severity of CAD, and the TyG index and TG / HDL-C ratio.Material and Methods: A total of 408 patients who underwent coronary angiography were evaluated in this study. TyG index, TG/HDL-C ratio and SYNTAX scores were calculated. Patients were grouped according to their diagnosis and SYNTAX scores. Relationships between TyG index, TG / HDL-C ratio and SYNTAX score were examined.Results: There is a significant relationship between the TyG index and the presence of CAD (p
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- 1. Malakar AK, Choudhury D, Halder B, Paul P, Uddin A, Chakraborty S. A review on coronary artery disease, its risk factors, and therapeutics. J Cell Physiol. 2019; 234(10): 16812-23.
- 2. Yadav M, Palmerini T, Caixeta A, Madhavan MV, Sanidas E, Kirtane AJ, et al. Prediction of coronary risk by SYNTAX and derived scores: Synergy between percutaneous coronary intervention with taxus and cardiac surgery. J Am Coll Cardiol. 2013; 62(14): 1219-30.
- 3. Wang XR, Song GR, Li M, Sun HG, Fan YJ, Liu Y, et al. Longitudinal associations of high-density lipoprotein cholesterol or low-density lipoprotein cholesterol with metabolic syndrome in the Chinese population: a prospective cohort study. BMJ Open. 2018; 8(5): e018659.
- 4. Lee EY, Yang HK, Lee J, Kang B, Yang Y, Lee SH, et al. Triglyceride glucose index, a marker of insulin resistance, is associated with coronary artery stenosis in asymptomatic subjects with type 2 diabetes. Lipids Health Dis. 2016; 15(1): 155.
- 5. Mach F, Baigent C, Catapano AL, Koskinas KC, Casula M, Badimon L, et al; ESC Scientific Document Group. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Eur Heart J. 2020; 41(1): 111-88.
- 6. Patel A, Barzi F, Jamrozik K, Lam TH, Ueshima H, Whitlock G, et al. Serum triglycerides as a risk factor for cardiovascular diseases in the Asia-Pacific region. Circulation. 2004; 110: 2678e86.
- 7. Gaziano JM, Hennekens CH, O'Donnell CJ, Breslow JL, Buring JE. Fasting triglycerides, highdensity lipoprotein, and risk of myocardial infarction. Circulation. 1997; 96: 2520-5.
- 8. Barzi F, Patel A, Woodward M, Lawes CM, Ohkubo T, Gu D, et al. A comparison of lipid variables as predictors of cardiovascular disease in the Asia Pacific region. Ann Epidemiol. 2005; 15: 405e13.
- 9. Gaziano JM, Hennekens CH, O’Donnell CJ, Breslow JL, Buring JE. Fasting triglycerides, highdensity lipoprotein, and risk of myocardial infarction. Circulation 1997; 96: 2520e5.
- 10. Wan GX, Xia WB, Ji LH, Qin HL, Zhang YG. Triglyceride to high density lipoprotein cholesterol ratio may serve as a useful predictor of major adverse coronary event in female revascularized STelevation myocardial infarction. Clin Chim Acta. 2018; 485: 166-72.
- 11. Sianos G, Morel MA, Kappetein AP, Morice MC, Colombo A, Dawkins K, et al. The SYNTAX Score: an angiographic tool grading the complexity of coronary artery disease. EuroInterv. 2005; 1(2): 219-27.
- 12. da Silva A, Caldas APS, Hermsdorff HHM, BerschFerreira AC, Torreglosa CR, Weber B, et al. Triglyceride-glucose index is associated with symptomatic coronary artery disease in patients in secondary care. Cardiovasc Diabetol. 2019; 18(1): 89.
- 13. Won KB, Park GM, Lee SE, Cho IJ, Kim HC, Lee BK, et al. Relationship of insulin resistance estimated by triglyceride glucose index to arterial stiffness. Lipids Health Dis. 2018; 17(1): 268.
- 14. Mao Q, Zhou D, Li Y, Wang Y, Xu SC, Zhao XH. The triglyceride-glucose ındex predicts coronary artery disease severity and cardiovascular outcomes in patients with non-st-segment elevation acute coronary syndrome. Dis Markers. 2019; 11: 2019:6891537. doi: 10.1155/2019/6891537.
- 15. Luo E, Wang D, Yan G, Qiao Y, Liu B, Hou J, et al. High triglyceride-glucose index is associated with poor prognosis in patients with acute ST-elevation myocardial infarction after percutaneous coronary intervention. Cardiovasc Diabetol. 2019; 18(1): 150.
- 16. Bhalodkar NC, Blum S, Enas EA. Accuracy of the ratio of triglycerides to high-density lipoprotein cholesterol for predicting low-density lipoprotein cholesterol particle sizes, phenotype B, and particle concentrations among Asian Indians. Am J Cardiol. 2006; 97: 1007-9.
- 17. Hadaegh F, Khalili D, Ghasemi A, Tohidi M, Sheikholeslami F, Azizi F. Triglyceride/HDLcholesterol ratio is an independent predictor for coronary heart disease in a population of Iranian men. Nutr Metab Cardiovasc Dis. 2009; 19: 401-8.
- 18. Masson W, Siniawski D, Lobo M, Molinero G, Huerín M. Association between triglyceride/HDL cholesterol ratio and carotid atherosclerosis in postmenopausal middle-aged women. Endocrinol Nutr. 2016; 63(7): 327-32.
- 19. Dogan C, Bayram Z, Karagoz A, Bakal RB, Erdogan E, Yilmaz F, et al. Is elevated triglyceride high density lipoprotein cholesterol ratio a risk factor that causes acute coronary syndrome to appear earlier? Bratisl Lek Listy. 2018; 119(12): 770-5.
- 20. Su YM, Zhang R, Xu RF, Wang HL, Geng HH, Pan M, et al. Triglyceride to high-density lipoprotein cholesterol ratio as a risk factor of repeat revascularization among patients with acute coronary syndrome after first-time percutaneous coronary intervention. J Thorac Dis. 2019; 11(12): 5087-95.
- 21. Yunke Z, Guoping L, Zhenyue C. Triglyceride-toHDL cholesterol ratio. Predictive value for CHD severity and new-onset heart failure. Herz. 2014; 39(1): 105-10.
- 22. Chen BD, Chen XC, Yang YN, Gao XM, Ma X, Huang Y, et al. Apolipoprotein A1 is associated with SYNTAX score in patients with a non-ST segment elevation myocardial infarction. Lipids Health Dis. 2019; 18(1): 159.
- 23. Volkan Emren S, Gediz RB, Şenöz O, Karagöz U, Şimşek EÇ, Levent F, et al. Decreased heart rate recovery may predict a high SYNTAX score in patients with stable coronary artery disease. Bosn J Basic Med Sci. 2019; 19(1): 109-15.
- 24. Strisciuglio T, Izzo R, Barbato E, Di Gioia G, Colaiori I, Fiordelisi A, et al. Insulin resistance predicts severity of coronary atherosclerotic disease in non-diabetic patients. J Clin Med. 2020; 9(7): 2144.
- 25. Srinivasan MP, Kamath PK, Bhat NM, Pai ND, Bhat RU, Manjrekar PA, et al. Manipal diabetes coronary artery severity score. Diabetes Metab Syndr. 2017; 11(Suppl): 33-7.
- 26. Khan SH, Sobia F, Niazi NK, Manzoor SM, Fazal N, Ahmad F. Metabolic clustering of risk factors: evaluation of Triglyceride-glucose index (TyG index) for evaluation of insulin resistance. Diabetol Metab Syndr. 2018; 10: 74.
- 27. Raimi TH, Dele-Ojo BF, Dada SA, Fadare JO, Ajayi DD, Ajayi EA, et al. Triglyceride-Glucose Index and Related Parameters Predicted Metabolic Syndrome in Nigerians. Metab Syndr Relat Disord. 2020; 19(2): 76-82.