Endemik Alcea calvertii (Boiss) Boiss. Çiçeklerinin In vitro Antiradikal, Antimikrobiyal ve Antiproliferatif Aktiviteleri ve Fitokimyasal Kompozisyonu

Alcea calvertii (Boiss) Boiss. Malvaceae familyasında yer alan çok yıllık otsu endemik bir bitkidir. Alcea genusuna ait bitkiler bahçelerde süs bitkileri olarak yetiştirilirler. Sunulan çalışmada, Alcea calvertii çiçeklerinin su, etanol, metanol ve aseton ekstraktlarının antiproliferatif, antimikrobiyal, antiradikal aktiviteleri ve fitokimyasal kompozisyonları incelendi. A. calvertii çiçeklerinin su, etanol, metanol ve aseton ekstraktlarının standart antioksidan trolokstan daha düşük oranda DPPH, ABTS ve OH radikali yok ettiği saptandı. A. calvertii çiçeklerinin vitamin, sterol, flavonoit ve fenolik asitler içerdiği ve yüksek miktarda vanillik asit, gallik asit, kateşin, δ-tokoferol, ergosterol ve vitamin D içerdiği belirlendi. A. calvertii su ekstraktının MCF-7 ve HCT-116 kanser hücrelerine karşı diğer ektstraktlardan daha iyi antiproliferatif aktivite gösterdiği gözlendi. LNCaP hücre serilerine karşı ise A. calvertii metanol ekstraktı daha yüksek antiproliferatif aktivite gösterdi.

Anahtar Kelimeler:

Alcea calvertii, antiradikal, antimikrobiyal, antiproliferatif, fitosterol

In vitro Antiradical, Antimicrobial and Antiproliferative Activities and Phytochemical Compositions of Endemic Alcea calvertii (Boiss) Boiss. Flowers

Alcea calvertii (Boiss) Boiss. is belonged to Malvaceae family, and it is a perennial herbaceous endemic plant. Alcea genus plants are grown as ornamental plants in the gardens. In the present study, the antiproliferative, antimicrobial, antiradical activities and phytochemical compositions of ethanol, water, methanol and acetone extracts of A. calvertii flowers were examined. A. calvertii flowers water, ethanol, methanol and acetone extracts are lower scavenged DPPH, ABTS and OH radicals than standard antioxidant trolox. A. calvertii flowers contain vitamins, sterols, flavonoids and phenolic acids, dominated by vanillic acid, gallic acid, catechin, δ-tocopherol, ergosterol and vitamin D. A. calvertii flowers water extract showed better antiproliferative activities than other extracts against to MCF-7 and HCT-116 cell lines. A. calvertii flowers methanol extract showed higher antiproliferative effect against to LNCaP cell lines.

Keywords:

Alcea calvertii, antiradical, antimicrobial, antiproliferative, phytosterol,

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