Çocuk psikiyatrisi pratiğinde nadir bir durum: Çocukluk çağı dezintegratif bozukluğu

Çocuk psikiyatrisi pratiğinde nadir bir durum: Çocukluk çağı dezintegratif bozukluğuÇocukluk çağı dezintegratif bozukluğu, yaşamın ilk iki yılında sözel ve sözel olmayan iletişim, sosyal etkileşim becerileri, oyun, mesane ve barsak kontrolü ile motor davranış alanlarında normal gelişimi takiben 2-10 yaşları arasında belirtilen alanların en az ikisinde gerileme izlenen ve son derece nadir görülen bir yaygın gelişimsel bozukluktur. Tahmini prevalansı 100.000'de 1.1 ve 6.4 arasında değişmektedir ve ortalama başlangıç yaşının 3.36 olduğu ifade edilmektedir. Bu yazıda üç yıllık normal gelişimin ardından çocukluk çağı dezintegratif bozukluğu belirtileriyle başvuran bir erkek olgu sunulmuş, klinik izlemi ve klinisyenlere verebileceği ipuçları literatürdeki bilgiler ışığında tartışılmıştır

A Rare Condition in Child Psychiatry Practice: Childhood Disintegrative Disorder

Childhood disintegrative disorder is a very rare pervasive developmental disorder characterized by normal development of verbal and nonverbal communication skills, social interaction, play, bladder and bowel control and motor behavior at least in the first two years, followed by regression between 2-10 years of age in two or more of the mentioned developmental areas. Estimated prevalence of the childhood disintegrative disorder is around 1.1-6.4 per 100.000 children and the common age of onset is 3.36 years. The present report describes a boy who developed childhood disintegrative disorder after approximately 3 years of normal development and clinical features are discussed in the light of the clinical literature

PDF

___

1. Yorbik O. Disintegrative Psychosis: In Cuhadaroglu F (editor). Child and Adolescent Psychiatry Textbook. Ankara: Hekimler Yayin Birligi, 2008, 540-53. (Turkish)
2. World Health Organization (WHO). International Classification of Diseases. Tenth ed. (ICD-10), Geneva: World Health Organization, 1994.
3. American Psychiatric Association (APA). Mental Bozukluklarin Tanisal ve Sayimsal El Kitabi, (DSM-IV), Koroglu E (translation editor) Fourth ed. Ankara: Hekimler Yayin Birligi, 1995. (Turkish)
4. American Psychiatric Association (APA). DSM 5. Autism Spectrum Disorder. http://www.dsm5.org/Documents/ Autism%20Spectrum%20Disorder%20Fact%20Sheet.pdf. Accessed January 13, 2014.
5. Kurita H, Osada H, Miyake Y. External validity of childhood disintegrative disorder in comparison with autistic disorder. J Autism Dev Disord 2004; 34:355-362.
6. Fombonne E. Prevalence of childhood disintegrative disorder. Autism 2002; 6:149-157.
7. Chakrabarti S, Fombonne E. Pervasive developmental disorders in preschool children. JAMA 2001; 285:3093-3099.
8. Volkmar FR. Childhood disintegrative disorder: issues for DSMIV. J Autism Dev Disord 1992; 22:625-642.
9. Homan KJ, Mellon MW, Houlihan D, Katusic MZ. Brief report: childhood disintegrative disorder: a brief examination of eight case studies. J Autism Dev Disord 2011; 41:497-504.
10. Charan SH. Childhood disintegrative disorder. J Pediatr Neurosci 2012; 7:55-57.
11. Durukan, IA, Tufan AE, Turkbay T. Risperidone treatment may benefit childhood disintegrative disorder: presentation of two cases. Bulletin of Clinical Psychopharmacology 2009; 19:285-288.
12. Rosman NP, Berta MB. Childhood disintegrative disorder distinction from autistic disorder and predictors of outcome. J Child Neurol 2013; 28:1587-1598.
13. Sanberk S, Eroglu MZ. Childhood disintegrative disorder; a case report. Anatolian Journal of Psychiatry 2013; 14:174-177. (Turkish)
14. Malhotra S, Gupta N. Childhood disintegrative disorder. Re-examination of the current concept. Eur Child Adolesc Psychiatry 2002; 11:108-114.
15. Volkmar FR, Klin A, Marans W, Cohen DJ. Childhood Disintegrative Disorder: Cohen DJ & Volkmar FR (editors). Handbook of Autism and Pervasive Developmental Disorders. New York: Wiley Press, 1997, 60-93.
16. Yorbik O, Akin R, Sohmen T. Childhood disintegrative disorder and a case report. Turkish Journal of Child and Adolescent Mental Health 2000; 7:43-50. (Turkish)
17. Agarwal V, Sitholey P, Mohan I. Childhood disintegrative disorder, an atypical presentation: a case report. J Autism Dev Disord 2005; 35:873-874.
18. Kaidar M, Zalsman G. Olanzapine for childhood disintegrative disorder. Isr J Psychiatry Relat Sci 2004; 41:71-72.
19. Malhotra S, Gupta N. Childhood disintegrative disorder. J Autism Dev Disord 1999; 29:491-498.
20. Dinca O, Paul M, Spencer NJ. Systematic review of randomized controlled trials of atypical antipsychotics and selective serotonin reuptake inhibitors for behavioural problems associated with pervasive developmental disorders. J Psychopharmacol 2005; 19:521-532.