Andac TOPKAN, Şule BİLEN, Esra ERUYAR, Yeşim KARADAĞ SUCULLU

Anti-NMDA Receptor Encephalitis: a Neuropsychiatric Entity

Anti-NMDA reseptör ensefaliti: Bir nöropsikiyatrik antiteAnti-NMDA reseptör ensefaliti; akut veya subakut başlangıçlı psikiyatrik semptomlar, nöbet, otonomik disfonksiyon ve hareket bozuklukları ile kendini gösteren bir otoimmün ensefalit türüdür. Yüzde 20 oranında fatal seyredebilen, agresif immünsüpresif tedaviyle sekelsiz iyileşmenin görülebildiği, nispeten yeni tanımlanmış, bir formdur. Kraniyal manyetik rezonans görüntülemede multifokal, spesifik olmayan, subkortikal beyaz cevher lezyonları görülebilir. Çoğunlukla paraneoplastik etiyolojiye sahip olması nedeniyle tanı sonrasında malignite taraması önem arz eder. Tanı konulması, muhtemel bir malignitenin erken tanısına olanak sağlaması açısından oldukça önemlidir. Yazımızda gürültülü nöropsikiyatrik tablo ile polikliniğimize getirilen, yapılan değerlendirmeler sonucunda anti-NMDA reseptör ensefaliti tanısı alan ve tedavi ile tam düzelmenin görüldüğü bir olgu sunulmaktadır.

Anti-NMDA reseptör ensefaliti: Bir nöropsikiyatrik antite

Anti-NMDA receptor encephalitis: a neuropsychiatric entityAntiNMDA receptor encephalitis is a form of autoimmune encephalitis which manifests itself with acute or subacute onset psychiatric symptoms, seizures, autonomic dysfunction, and movement disorders. It is a rather recently described form which may progress fatal at about 20%, and which may recover with aggressive immunosuppressive treatment without any sequela. Multifocal, non-specific, subcortical white matter lesions can be observed in cranial magnetic resonance imaging. Since mostly it has paraneoplastic etiology, it is crucial to screen for malignancies after the diagnosis. Its diagnosis is very important, because it will lead early diagnosis of a possible mallignancy. In the present article, a case which applied to our outpatient clinic with noisy neuropsychiatric clinical picture, and was diagnosed with anti-NMDA receptor encephalitis after evaluations, and treated with complete recovery, was presented.

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