Bir hepatit A infeksiyonu olgusunda EDTA'ya bağlı pseudotrombositopeni
Pseudotrombositopeni kanama riskinde artışa neden olmayan ve trombosit transfüzyonu gerektirmeyen bir iyatrojenik laboratuar fenomenidir. Etilendiami-notetraasetik asid'e (EDTA) bağlı pseudotrombositopeni, otomatik kan sayımında yalancı olarak trombosit sayısındaki azalmayı tanımlamaktadır. Kan örneklerinin EDTA ile antikoagule edilmesi sonucunda normal kişilerde oluşabileceği gibi farklı hastalıkların seyrinde de gözlenebilmektedir. Bu yazıda hepatit A infeksiyonu seyrinde gözlenen bir EDTA bağımlı pseudotrombositopeni olgusu sunulmuştur. Olgu halen devam eden pseudotrombositopeni nedeniyle izlenmektedir.
EDTA induced pseudothrombocytopenia in a patient with hepatitis A infection
Pseudothronıbocytopenia is an iatrogenic laboratory phenomenon that does not increase the risk of bleeding or the need for platelet transfusion. The term ethylenediaminotetraacetic acid (EDTA) induced pseudothronıbocytopenia, defines false low platelet count when measured with automatic counters. It may occur in both normal individuals and patients with a variety of diseases when their blood samples are anticoagulated with EDTA. Here we report a patient with EDTA induced pseudothronıbocytopenia during the course of hepatitis A infection. The patient is still being followed up with pseudothrombocytopenia.
___
- 1. Holmes MB, Kabbani S, Watkins MW, Battle RW, Schneider DJ. Images in cardiovascular medicine. Abciximab-associated pseudothrombocytopenia. Circulation 2000; 101:938-939.
- 2. Bizzaro N, Brandalise M. EDTA-dependent pseudothrombocytopenia. Association with antiplatelet and antiphospholipid antibodies. Am J Clin Pathol 1995; 103: 103-107.
- 3. Bizzaro N. EDTA-dependent pseudothrombocytopenia: a clinical and epidemiological study of 112 cases, with 10-year followup. Am J Hematol 1995; 50:103-109.
- 4. Hsieh AT, Chao TY, Chen YC. Pseudothrombocytopenia associated with infectious mononucleosis. Arch Pathol Lab Med 2003; 127:17-18.
- 5. Gschwandtner ME, Siostrzonek P, Bodinger C, et al. Documented sudden onset of pseudothrombocytopenia. Ann Hematol 1997; 74:283- 285.
- 6. Tomonari A, Hirai K, Aoki H, et al. [Pure red cell aplasia and pseudothrombocytopenia associated with hepatitis A]. Rinsho Ketsueki 1991; 32:147-151.
- 7. Takeuchi T, Yoshioka K, Hori A, Mukoyama K, Ohsawa A, Yokoh S. Cytomegalovirus mononucleosis with mixed cryoglobulinemia presenting transient pseudothrombocytopenia. Intern Med 1993; 32:598- 601.
- 8. Sawazaki A, Nakamura N, Jyokaji H, Minami S, Nakamura S, Matsuda T. Guillain-Barre syndrome and ethylene diamine tetraacetic acid-dependent pseudothrombocytopenia associated with mumps. Intern Med 1996; 35:996-999.
- 9. Saburi Y, Aragaki M, Matsui S, et al. [An adult patient with EDTA-dependent pseudothrombocytopenia due to rubella virus infection]. Kansenshogaku Zasshi 1993; 67:594-597.
- 10.Muniz-Diaz E, Domingo P, Lopez M, Pujol-Moix N, Fuster M, Madoz P. [Thrombocytopenia associated with human immunodeficiency virus infection. Immunologic study of 60 patients addicted to parenteral drugs]. Med Clin (Barc) 1993; 101:761-765.
- 11.Mori M, Kudo H, Yoshitake S, Ito K, Shinguu C, Noguchi T. Transient EDTA-dependent pseudothrombocytopenia in a patient with sepsis. Intensive Care Med 2000; 26:218-220.
- 12. Lipson PJ. What's that platelet count?: A case of pseudothrombocytopenia in an obstetric patient. Anesthesiology 1994; 80:478.
- 13. Berkman N, Michaeli Y, Or R, Eldor A. EDTAdependent pseudothrombocytopenia: a clinical study of 18 patients and a review of the literature. Am J Hematol 1991; 36:195-201.
- 14.Harle JR, Disdier P, Aillaud MF, Swiader L, Weiller PJ. [A virus from the herpes group and pseudothrombocytopenia: two cases]. Rev Med Interne 1992; 13:324-325.