Köpeklerde İstenmeyen Gebeliklerin Sonlandırılmasına Güncel Medikal Yaklaşımlar

Köpeklerde, sıklıkla karşılaşılan istenmeyen gebeliklerin sonlandırılmasında yıllardır farklı yöntemler kullanılmaktadır. Bu yöntemler hayvanların bir daha gebe kalmasını engelleyebildiği gibi, mevcut gebeliğin sonlandırılmasını takiben tekrar gebe kalmasına da olanak sağlar. Hayvanların kalıcı olarak doğurganlığını kaybetmesini istemeyen hayvan sahipleri için, istenmeyen gebeliği sonlandırmak amacıyla çeşitli farmakolojik ajanlar tercih edilir. Bu kimyasal maddeler gebeliğin farklı dönemlerinde farklı yöntemlerle uygulanmaktadır. Son yıllarda en çok kullanılan farmakolojik maddeler; Prostaglandinler, Ergot Alkaloidleri, Mifepristone, Aglepristone, GnRH Agonistleri ve GnRH Antagonistleri’dir. Bu ilaçlar tek başlarına kullanılabildiği gibi, birlikte kullanıldıklarında daha başarılıdırlar. Köpeklerde gebeliğin ilk ve ikinci yarısında endokrinoloji farklıdır. Bu nedenle istenmeyen gebeliklerin sonlandırılması için yapılan girişimler gebeliğin ilk yarısı ve ikinci yarısı için farklılık gösterir. 

Current Medical Approaches to the Termination of Unwanted Pregnancies in Dogs

Throughout the years, different methods have been used to terminate unwanted pregnancies of dogs which have been often encountered. These methods may sterilize these aminals as well as after the pegnancy is terminated these methods may also allow dogs to have an oppurtunity to get pregnant again. Pet owners who do not want their dogs to be sterilized, different pharmacological agents can be preferred to terminate the unwanted pregnancy. These chemical substances are applied at different terms of the pregnancy through different tecniques. In recent years, the most commonly used pharmacological agents are prostaglandins, ergot alkaloids, Mifepristone, Aglepristone, GnRH Agonists and GnRH Antagonists. These edications can be used by themselves , but they are more successfull when they are used in combination with each other. The endocrinology of dogs is not same in the first and second half-term of pregnancy. For this reason, the applications to terminate unwanted pregnancies in the first and second half-term of pregnancies are different from each other. 

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  • 1. Johnston SD, Kustritz VR, Olson PNS. (2001). Prevention and termination of canine pregnancy. Ed(s): Johnston SD, Kustritz VR, Olson PNS, Canine and Feline Theriogenology. WB Saunders Company, Philedelphia, p: 168- 192.
  • 2. Concannon PW, England G, Verstegen J. (2000). Recent advances in small animal reproduction. Ed(s): P.W. Concannon, G. England, J. Verstegen and C. Linde-Forsberg. Publisher: International Veterinary Information Service (www.ivis.org), Ithaca, New York, USA, (11.05.2011).
  • 3. Concannon PW. (2004). Contraception in dogs and cats. 29th World congres of the World Small Anim Vet Assoc, Rodos, Greece.
  • 4. Eilts BE. (2002). Pregnancy termination in the bitch and queen. Clin Tech Small An P. 17: 116-123.
  • 5. England GCW. (1994), Hormonal maniplation of breeding in the bitch. The Veterinary Annual. 34: 189-200.
  • 6. Feldman EC, Nelson RW. (1997). Canine female reproduction, Canine and Feline Endocrinology and Reproduction, W.B. Saunders Co., Philadelphia, p:556-600.
  • 7. Günzel-Apel AR, Zabel S, Bunck CF, Dieleman SJ, Einspanier A, Hoppen HO. (2006). Concentrations of progesterone, prolactin and relaxin in the luteal phase and pregnancy in normal and short- cycling german shepherd dogs. Theriogenology. 66: 1431-1435.
  • 8. Braakman A, Okkens AC, Haaften B. (1993). Medical methods to terminate pregnancy in the dog. Comp Contin Educ Pratt Vet Small Anim Pratt. 15: 1505-1512.
  • 9. Feldman EC, Davidson AP, Nelson RW, Nyland TG, Munro C. (1993). Prostaglandin induction of abortion in pregnant bitches after misalliance. J Am Vet Med Assoc. 202: 1855- 1858.
  • 10. Fieni M, Fuhrer D, Tainturier JF, Bruyas, Dridi S. (1989). Use of PGF2α analog, cloprostenol, for pregnancy termination in dogs. J Reprod Fertil Suppl. 39: 332-333.
  • 11. Concannon PW. (1986). Canine pregnancy and parturition. Vet Clin North Am Small Anim Pract. 16: 453-475.
  • 12. Romagnoli SE, Camillo F, Novellini S, Johnson SD, Cela M. (1996). Luteolytic effects of prostoglandin F2α on day 8 to 19 corpora lutea in the bitch. Theriogenology. 45: 397-403.
  • 13. Romagnoli S. (2006). Control of reproduction in dogs and cats: use and misuse of hormones. World Congress WSAVA/FECA/CSAVA, Praque, Czech Republic.
  • 14. Johnson CA. (1992). False pregnancy, disorders of pregnancy, parturition and the postpartum period. Ed(s): Nelson RW, Couto CG, Essentials of Small Animal Internal Medicine, Mosby Year Book, Boston, p:677- 678.
  • 15. Cain JL. (1998). Drugs used to treat reproductive disorders. Vet Clin North Am Small Anim Pract. 28: 395-410.
  • 16. Concannon PW. (1986). Current veterinary therapy, small animal practice. 9th edition, W. B. Saunders Co. ; Philadelphia, p: 1218-1240.
  • 17. Erünal-Maral N, Aslan S, Findik M, Yüksel N, Handler J, Arbeiter K. (2004). Induction of abortion in queens by administration of cabergoline (Galastop) solely or in combination with the PGF2alpha analogue Alfaprostol (Gabbrostim). Theriogenology. 61: 1471-1475.
  • 18. Gobello C, Castex G, Corrada Y, Klima L, de la Sota RL, Rodríguez R. (2002). Use of prostaglandins and bromocriptine mesylate for pregnancy termination in bitches. J Am Vet Med Assoc. 220:1017-1019.
  • 19. Palmer CW, Post K. (2002). Prevention of pregnancy in the dog with a combination of prostaglandin F2α and bromocriptine. Can Vet J. 43: 460–462.
  • 20. Onclin K, Silva LD, Verstegen JP. (1995). Termination of unwanted pregnancy in dogs with the dopamine agonist, cabergoline, in combination with a synthetic analog of PGF2alpha, either cloprostenol or alphaprostol. Theriogenology. 43: 813-822.
  • 21. Heikinheimo O, Haukkamaa M, Lahteenmaki P. (1989). Distribution of RU486 and its demethylated metabolites in human. J Clin Endocrinol Metab. 68: 270-275.
  • 22. Sarkar NN. (2002). Mifepristone: bioavailability, pharmacokinetics and useeffectiveness. Eur J Obstet Gyn. 101: 113-120.
  • 23. Cetin Y, Macun HC, Beceriklisoy HB, Schäfer-Somi S, Aslan S. (2010). Intravaginal application of misoprostol improves pregnancy termination with cabergoline and alfaprostol in dogs. Berl Munch Tierarztl Wochenschr. 123: 236-242.
  • 24. Hoffman B, Schuler G. (2000). Receptor blockers-general aspects with respect to their use in domestic animal reproduction. Anim Reprod Sci. 60-61: 295–312.
  • 25. Wiebe VJ, Howard JP. (2009). Pharmacologic advances in canine and feline reproduction. Top Companion Anim M. 24: 71- 99.
  • 26. Hoffmann B, Busges F, Engel E, Kowalewski MP, Papa P. (2004). Regulation of corpus luteum-function in the bitch. Reprod Domest Anim. 39: 232–240.
  • 27. Galac S, Kooistra HS, Butinar J, Bevers MM, Dieleman SJ, Voorhout G, Okkens AC. (2000). Termination of mid-gestation pregnancy in bitches with aglepristone, a progesterone receptor antagonist. Theriogenology. 53: 941- 950.
  • 28. Hull ME, Kenigsberg DJ. (1987). Gonadotropin releasing hormone: function and clinical use. Lab Manag. 25: 51–58.
  • 29. Güngör Ö, Kaya M, Gürbulak K, Oral H, Kaya S, Kaçar C. (2010). Use of GnRH Agonist (Desloreline) in Combination with PGF2α on the Termination of Pregnancy in Bitches. Kafkas Üniv Vet Fak Derg. 16: 903-908.
  • 30. Wright PJ, Verstegen JP, Onclin K, Jochle W, Armour AF, Martin GB, Trigg TE. (2001).