Nurten SERİNGEÇ AKKEÇECİ, Büşra SEĞMEN, SADIK YURTTUTAN, CAN ACIPAYAM, Zübeyde DİNÇER, GÖZEN ÖKSÜZ

Yenidoğan sepsisinde tam kan sayımı parametrelerinin tanısal değeri

Amaç: Bu çalışma tam kan sayımı parametrelerinin ve tam kan sayımına dayalı skorların yenidoğan sepsisinde tanısal biyo-belirteç olarak kullanılıp kullanılamayacaklarını belirlemek amacıyla planlanmıştır. Yöntemler: Retrospektif olarak planlanan bu çalışmaya, yenidoğan sepsisi tanısı almış 70 hasta (Grup 1) ve hasta grubuyla benzer yaş, cinsiyet, doğum ağırlığı ve doğum haftasında olan 65 sağlıklı yenidoğan (Grup 2) olarak çalışmaya alındı. Demografik veriler, kan kültürü sonuçları, klinik ve laboratuvar bulguları tıbbi kayıtlardan elde edildi. Nötrofil/lenfosit oranı (NLO), trombosit/lenfosit oranı (TLO), eozinofil/lenfosit oranı (ELO), bazofil/lenfosit oranı (BLO) ve monosit/lenfosit oranı (MLO) gibi tam kan sayımına dayalı skorlar, sırasıyla nötrofil, trombosit, eozinofil, bazofil ve monosit sayısının lenfosit sayısına bölünmesiyle hesaplandı. Bulgular: Yaş, cinsiyet, doğum tartısı, doğum şekli ve gebelik haftası gibi demografik özellikler bakımdan gruplar arasında fark yoktu (p>0,05). C-reaktif protein düzeyi yenidoğan sepsisi grubunda anlamlı olarak yüksekti (p

Diagnostic value of complete blood count parameters in neonatal sepsis

Objective: This study was planned to determine whether complete blood count parameters and scores based on complete blood count can be used as a diagnostic marker in neonatal sepsis. Methods: This retrospective study included 70 patients with neonatal sepsis (Group 1) and 65 healthy neonates (Group 2) with similar age, sex, birth weight, and gestational age. The demographic data, blood culture results, clinical and laboratory findings were obtained from the medical records. Scores based on complete blood count such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), eosinophil-to-lymphocyte ratio (ELR), basophil-to-lymphocyte ratio (BLR) and monocyte-to-lymphocyte ratio (MLR) were calculated by dividing the number of neutrophils, platelets, eosinophils, basophils and monocytes by the number of lymphocytes, respectively. Results: There were no significant differences between the groups in terms of demographic characteristics such as age, gender, birth weight, type of delivery and gestational week. C-reactive protein level was significantly higher in the neonatal sepsis group (p

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Omran A, Maaroof A, Saleh MH, Abdelwahab A. Salivary C-reactive protein, mean platelet volume and neutrophil lymphocyte ratio as diagnostic markers for neonatal sepsis. J Pediatr (Rio J). 2018; 94: 82-7.
Camacho-Gonzalez A, Spearman PW, Stoll BJ. Neonatal infectious diseases: evaluation of neonatal sepsis. Pediatr Clin North Am. 2013; 60: 367-89.
Raimondi F, Ferrara T, Maffucci R, et all. Neonatal sepsis: a difficult diagnostic challenge. Clin Biochem. 2011; 44: 463-4.
Gerdes JS. Diagnosis and management of bacterial infections in the neonate. Pediatr Clin N Am. 2004; 51: 939-59.
Zea-Vera A and Ochoa TJ. Challenges in the diagnosis and management of neonatal sepsis. J Trop Pediatr. 2015; 61: 1-13.
Sharma D, Farahbakhsh N, Shastri S, Sharma P. Biomarkers for diagnosis of neonatal sepsis: a literature review. J Matern Fetal Neonatal Med. 2018; 31: 1646-59.
Kaya Z. Interpretation of automated blood cell counts. Dicle Med J. 2013; 40: 521-8.
Ognean ML, Boicean A, Șular FL, Cucerea M. Complete blood count and differential in diagnosis of early onset neonatal sepsis. Rev Romana Med Lab. 2017; 25: 101-8.
Taşyurt N, Olukman Ö, Çalkavur Ş, et all. Diagnostic Value of Platelet Parameters in Neonatal Sepsis. Journal of Dr. Behcet Uz Children's Hospital 2012; 2: 10-7.
Hanaganahalli SB, Sreeram S, Bompada M, et all. Is MPV a Predictive Marker for Neonatal Sepsis? A Pilot Study. J Pediatr Hematol Oncol. 2018; 40: 548-52.
Wilar R. Diagnostic value of eosinopenia and neutrophil to lymphocyte ratio on early onset neonatal sepsis. Korean J Pediatr. 2018 Oct 8. doi: 10.3345/kjp.2018.06723.
Ellahony DM, El-Mekkawy MS, Farag MM. A Study of Red Cell Distribution Width in Neonatal Sepsis. Pediatr Emerg Care. 2017 Oct 27. doi: 10.1097/PEC.0000000000001319.
Can E, Hamilcikan Ş, Can C. The Value of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio for Detecting Early-onset Neonatal Sepsis. J Pediatr Hematol Oncol. 2018; 40: e229-32.
Alkan Ozdemir S, Arun Ozer E, Ilhan O, Sutcuoglu S. Can neutrophil to lymphocyte ratio predict late-onset sepsis in preterm infants? J Clin Lab Anal. 2018; 32: e22338.
https://www.ema.europa.eu/documents/report/repor t-expert-meeting-neonatal paediatric-sepsis_en.pdf 16. Hedegaard SS, Wisborg K, Hvas A-M. Diagnostic utility of biomarkers for neonatal sepsis-a systematic review. Infect Dis (Lond). 2015; 47: 117–24.
Kılıç E, Rezvani A, Toprak Erek A, et all. Evaluation of Neutrophil to Lymphocyte and Platelet to Lymphocyte Ratios in Rheumatoid Arthritis. Dicle Med J. 2016; 43: 241-7.
An I, Uçmak D. Evaluation of neutrophil-tolymphocyte ratio, platelet-to-lymphocyte ratio, mean platelet volume, and C-reactive protein in patients with psoriasis vulgaris. Dicle Med J. 2018; 45: 327-34.
Yorulmaz A, Yücel M, Sert S. Diagnostic value of haematological parameters in neonatal sepsis cases. Ortadogu Medical Journal 2018; 10: 252-62.
Choudhary RR, Makwana M, Mourya HK, Dabi J, Gulati K. Evaluation of platelet and its indices as a marker of neonatal sepsis: a prospective case control study. Int J Contemp Pediatr. 2018; 5: 1898-1903.
Bass DA. Behavior of eosinophil leukocytes in acute inflammation.II. Eosinophil Dynamics during acute inflammation.J Clin Invest. 1975; 56: 870–9.
Gil H, Magy N, Mauny F, Dupond JL. Value of eosinopenia in inflammatory disorders: an “old” marker revisited. Rev Med Interne. 2003; 24: 431–5.
Abidi K, Khoudri I, Belayachi J, et all. Eosinopenia is a reliable marker of sepsis on admission to medical intensive care units. Crit Care. 2008; 12: R59.
Yang Z, Zhang Z, Lin F, et all. Comparisons of neutrophil-, monocyte-, eosinophil-, and basophillymphocyte ratios among various systemic autoimmune rheumatic diseases. APMIS. 2017; 125: 863-71.
Kamei M, Carman CV. New observations on the trafficking and diapedesis of monocytes. Curr Opin Hematol. 2010; 17: 43-52.
Gille-Johnson P, Smedman C, Gudmundsdotter L, et all. Circulating monocytes are not the major source of plasma cytokines in patients with sepsis. Shock. 2012; 38: 577-83.