İbrahim KAPLAN, Mazhar Müslüm TUNA, Alpaslan Kemal TUZCU, Zafer PEKKOLAY, Zeki AKKUŞ, Şadiye ALTUN TUZCU, Mehmet GÜVEN

Makroprolaktinemi tanısı için alternatif yöntemler: İdrar prolaktin düzeyi ve serum / idrar prolaktin oranı

Amaç: Bu çalışmanın amacı makroprolaktinemi tanısında idrar prolaktin ve serum / idrar prolaktin oranının doğruluğunu araştırmaktır. Yöntemler: Kesitsel analiz olan çalışmamızda, reprodüktif dönemdeki kadın ve erkeklerden prolaktin düzeyi bakılan (yüksek veya normal) hastalar çalışmaya alındı. Makroprolaktinemi tespiti için polietilen glikol (PEG) ile çöktürme yöntemi kullanıldı. Daha sonra hastalar makroprolaktinemi, prolaktinoma ve sağlıklı kontrol grubu olmak üzere üç gruba ayrıldı. Hastalarda eş zamanlı serum prolaktin ve spot idrarda prolaktin çalışıldı. Non-parametrik test olan Kruskal-Wallis testi grupların karşılaştırılmasında kullanıldı. Serum/idrar prolaktin oranının prediktif gücünü değerlendirmek için “receiver-operating characteristic (ROC)” eğrisi belirlendi ve bu analizde “cut-off” değeri elde edildi. Sonuçlar: Çalışmaya toplam 41 hasta dahil edildi. Kadın/erkek: 36 (%87,8) / 5 (%12,2). İdrar prolaktin medyan (minimum-maksimum) değerleri makroprolaktinemi, prolaktinoma ve kontrol grubunda sırasıyla; 0.06(0.05-0.10), 0.11(0.02-0.95), 0.08(0.05-0.25) ng/ml idi. Serum/idrar prolaktin oranı medyan (minimum-maksimum) değerleri makroprolaktinemi, prolaktinoma ve kontrol grubunda sırasıyla; 633(51-1032), 990(104-9635), 395.5(138-953) idi. Gruplar karşılaştırıldığında prolaktinoma olan hastalar daha yüksek üriner prolaktin seviyelerine sahipti. Makroprolaktinemili hastalar en düşük idrar prolaktin değerlerine sahipti(p

Alternative methods for the diagnosis of macroprolactinemia: urine prolactin level and serum / urine prolactin ratio

Objective: The aim of this study was to investigate the urine prolactin and serum/urine prolactin ratio for accuracydiagnosis of macroprolactinemia.Methods: In the retrospective cross-sectional analysis, prolactin levels (high or normal) in the reproductive period ofmen and women were included in the study. Polyethylene glycol (PEG) precipitation method was used for thedetection of macroprolactinemia. Then, patients were divided into three groups as macroprolactinemia, prolactinomaand healthy control group. In patients, prolactin values in spot urine with simultaneous serum prolactin values werecalculated. The non-parametric Kruskal-Wallis test was used to compare the groups. The receiver-operatingcharacteristic (ROC) curve was determined to evaluate the predictive power of serum/urine prolactin ratio.DOI: 10.5798/dicletip.534848Yazışma Adresi / Correspondence Zafer Pekkolay, Dicle University Faculty of Medicine ,Department of Internal Medicine-Endocrinology, Sur,Diyarbakir, Turkey e-mail: drpekkolay@gmail.comResults: A total of 41 patients were included in the study. Female/male:36 (87.8%)/ 5 (12.2%). Urinary prolactinmedian(minimum-maximum) values were macroprolactinemia, prolactinoma and control group, respectively;0.06(0.05-0.10), 0.11(0.02-0.95), 0.08(0.05-0.25) ng/ml. Serum/urine ratio median (minium-maximum) values weremacroprolactinemia, prolactinoma, and control group, respectively; 633(51-1032), 990(104-9635), 395.5(138-953).When the groups were compared, the patients with prolactinoma had higher urinary prolactin levels(p

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