Olanzapine Bağlı Obsesif-Kompülsif Semptomlar Oluşan Bir Capgras Sendromu Olgusu

Capgras sendromu, kişinin kendisine yakın olan diğer kişilerin, nesnelerin, kendisinin tıpatıp benzerleri iledeğiştirildikleri biçiminde sanrısal bir inanıştır. Bu sendrom daha çok şizofreni kavramı içinde yer alır. Capgrassendromunun tedavisi; altta yatan bozukluğun tedavisidir. Klozapin, risperidon, olanzapin ve ketiapin gibi tedavi içinkullanılan atipik antipsikotikler hastalarda obsesif kompülsif semptomlar meydana getirebilirler. Bu durumdahastanın psikotik belirtileri mevcut tedaviden fayda görüyorsa mevcut antipsikotik tedavi kesilmez. Bunun yerineserotonin geri-alım inhibitörü ya da klomipramin gibi obsesif kompülsif belirtiler için etkili başka bir grup ilaçeklenebilir.Bu yazıda olanzapin tedavisinden fayda gören Capgras sendromu bulunan, şizofreni tanısı konmuş bir hastadanbahsedilmiştir. Olanzapin tedavisi, hastada obsesif kompülsif semptomlar meydana getirmiştir. Obsesif kompülsifbelirtiler, Yale-Brown Obsesyon Kompulsiyon Derecelendirme Ölçeği ile değerlendirilmiştir. Hasta olanzapindenfayda gördüğü için olanzapin kesilmemiştir. Bunun yerine tedaviye fluoksetin eklenmiştir. Hastanın obsesif kompülsifbelirtileri tedaviye fluoksetin eklenmesiyle azalmıştır.

A Capgras Syndrome Case With Obsessive-Compulsive Symptoms Associated With Olanzapine

Capgras syndrome is a delusional belief that other people close to oneself, objects, are replaced with exactly the same ones. This syndrome is rarely seen and is included in the concept of schizophrenia. Treatment of Capgras syndrome is the treatment of the underlying psychiatric disorder. The atypical antipsychotics that are used to treat this syndrome such as risperidone, clozapine olanzapine, and quetiapine may cause obsessive-compulsive symptoms in patients. As it is, the patient's psychotic symptoms benefit from the present treatment, drugs those are effective for the obsessivecompulsive symptoms such as serotonin reuptake inhibitors, or clomipramine may be added to undergoing treatment, rather than existing antipsychotic treatment discontinuation. In this article, we mentioned of a schizophrenic patient with Capgras syndrome who profited from olanzapine treatment. The drug created obsessive-compulsive symptoms in the patient. The obsessive compulsive symptoms were evaluated with Yale-brown obsessive compulsive scale (Y-BOCS). Olanzapine treatment is continued as she benefited from the treatment. To overcome these symptoms, fluoxetine added to the treatment. Patient’s symptoms decreased with the addition of fluoxetine.

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