Zahide MAİL GÜRKAN, Aygül TANTİK PAK, Yıldızhan ŞENGÜL, İlker ÖZTÜRK

Karpal Tünel Sendromunun Şiddeti İle Nötrofil/Lenfosit ve Platelet/Lenfosit Oranının Arasındakı İlişki

Amaç: Bu çalışmada, karpal tünel sendromu (KTS)’nun şiddeti ile sistemik inflamasyonun belirteçlerinden nötrofil/lenfosit oranı (NLO) ve platelet/lenfosit oranı (PLO)’nın arasındaki ilişkiyi araştırmak amaçlanmıştır. Yöntemler: Bu çalışmaya Haziran 2020 ve Ocak 2021 tarihleri arasında Gaziosmanpaşa Eğitim ve Araştırma Hastanesi Nöroloji Kliniği Elektromiyografi laboratuvarına başvuran, klinik ve elektrofizyolojik olarak KTS tanısı konan 18 yaş üstü 119 hasta dahil edilmiştir. Hastaların tümüne elektrofizyolojik yöntemler ile tanı konulmuş ve hastalar KTS’nin şiddetine göre hafif, orta ve ağır olmak üzere 3 gruba ayrılmıştır. Tüm hastaların NLO ve PLO değerleri hesaplanmıştır. KTS’nin şiddetine göre NLO ve PLO değerleri arasındaki ilişki araştırılmıştır. Bulgular: Bu çalışmaya alınan hastaların 97’si (%81,5) kadındır. Hastaların yaş ortalamaları 49,86±12,21’dir. Hastaların elektrofizyolojik incelemelerine göre 74’ü (%62,2) hafif, 29’u (%24,4) orta ve 16’sı (%13,4) ağır olarak gruplandırılmıştır. Hastaların NLO’larının ortalaması 1,87±0,92, PLO’larının ortalaması 107,78±39,78’tir. Hastaların elektrofizyolojik yöntemlere göre sınıflandırılan hafif, orta ve ağır KTS grupları arasında NLO ve PLO değerleri karşılaştırıldığında anlamlı bir korelasyon bulunamamıştır (p=0,74, p=0,88). Sonuç: Bu çalışmada inflamasyonun, KTS'nin şiddeti üzerinde etkisi gösterilememiştir. Lokal inflamasyon olduğuna dair veriler olsa da noninflamatuar fibrozis, KTS patolojisinde önemlidir. Bunun yanı sıra sistemik inflamatuar hastalıklarda sıklıkla görülmesi, sistemik inflamasyon ile ilişkinin farklı açılardan araştırılmasını gerektirmektedir.

Anahtar Kelimeler:

Karpal tünel sendromu, inflamasyon, Nötrofil lenfosit oranı, Platelet lenfosit oranı, elektrofizyoloji

The Measurement of Neutrophil Gelatinase Associated Lipocalin in Umbilical Cord Blood and the Assessment of Its Relationship with Neonatal Results

Objectives: In this study, the relationship of cord blood Neutrophil Gelatinase-Associated Lipocalin (NGAL) with neonatal diseases was investigated. Methods: NGAL levels were measured in the cord blood of 180 babies born between 2015 and 2016. Patients were classified according to maternal diseases, neonatal diseases and demographic characteristics. Obtained data were compared with cord blood NGAL levels. Results: In our study, the mean NGAL levels were 1283.99 ng/mL in boys and 1306.52 ng/mL in girls. Umbilical cord blood NGAL levels of infants diagnosed with intrauterine growth retardation (1913.4±2833.5 ng/mL) and prolonged premature rupture of membranes (2594.2±2037.1 ng/mL) were found to be statistically high (p0.05). Conclusions: Neutrophil Gelatinase-Associated Lipocalin, may be useful as a diagnostic biomarker in the evaluation of maternal and neonatal diseases. However, studies on larger patient populations are needed.

Keywords:

Neutrophil Gelatinase Associated Lipocalin, umbilical cord blood, newborn,

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