Ağrı tedavisinde alternatif ilaçlar

Akut ve kronik ağrı yakınmasına yönelik tedavi yaklaşımları yüzyıllardır tıbbın ve araştırmacıların ilgi alanı olmuştur. Ağrının kontrolüne yönelik başlıca iki grup ilaç bulunmaktadır. Bunlar opioid ve non-opioid ilaçlardır. Bu ilaçlar tek başlarına ya da kombine edilmek suretiyle ağrı tedavisinde kullanılabilirler. Ancak günümüzde sayılan ajanlara bağlı gelişen tolerans, bağımlılık, gastrointestinal kanama ve böbrek yetmezliği gibi yan etkiler, ağrıya yaklaşımda alternatif ajanların geliştirilmesini gerekli kılmıştır. Yapılan çalışmalarda, konotoksinlerin opioidlerden farklı olarak bağımlılık ve tolerans gelişimine yol açmadığı ve aynı zamanda yan etkilerinin şiddetinin de daha düşük olduğu gösterilmiştir. Bu bakımdan ağrı tedavisinde alternatif ajanlara duyulan ihtiyacı gidermede biyotoksinler, özellikle de deniz kabuklularının zehirinde bulunan konotoksinler iyi bir seçenek olarak nitelendirilmektedir.

Anahtar Kelimeler:

Konotoksinler, Tamamlayıcı tedaviler, Ağrı

Alternative drugs in pain therapy

Various treatment modalities of acute and chronic pain have been an area of interest of medicine and investigators for centuries. There are two major classes of drugs that are used to control pain: opioid and non-opioid analgesics. They could be used in the case of monotherapy or combination therapy in pain management. However, these agents are not accepted as ideal drugs in clinical approaches against pain because of their serious side effects such as development of tolerance and addiction, renal failure and gastrointestinal bleeding. As a consequent, developing new forms of pain relievers that are more safe and effective without any other side effects has became the main goal of researchers. In recent studies, it has been shown that conotoxin therapies are not addictive, and have tolerable indexes unlike opioids. In addition, conotoxins side effects are much milder and easier to manage than those of opioids. In this regard, it has been emphasized that biotoxins such as conotoxins obtained from marine creatures can be better choices in pain management for future prospects.

Keywords:

Conotoxins, Complementary Therapies, Pain,

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