Sinan Soylu, Atilla Kurt, Ömer Topçu, Mustafa Atabey, Zeynep Deniz Şahin İnal

Stronsiyum ranilat ve Hypericum Perforatum eksraktının ratlarda deneysel kolit modeli üzerine etkileri

Amaç: Bu çalışmada stronsiyum ranilatın (SR), Hypericum perforatum (HP) ekstresinin deneysel kolit oluşturulan ratlarda iyileştirici etkisini tedavide kullanılan prednizolonun iyileştirici etkisiyle karşılaştırmak istedik. Yöntem: Çalışmada 30 adet Wistar albino rat kullanıldı. Ratlar 6’şarlı 5 gruba rastgele ayrıldı. Grup1 sağlıklı kolit oluşturulmamış ratlar, Grup 2 kolit oluşturulmuş fakat tedavi verilmemiş ratlar, Grup 3 kolit oluşturulup 160mg/kg SR verilen ratlar, Grup 4 kolit oluşturulup prednizolon (prednol-L Mustafa Nevzat®) (1mg/kg) verilenler, grup 5 kolit oluşturulup 0.3% hiperisin içeren HP ekstresi (250µg/300mg) verilen ratlar olarak gruplar oluşturuldu. Bütün tedavi gruplarına yedi gün boyunca oral gavaj yöntemi ile tedavileri uygulandı. Yedinci gün sonunda ratların kolonları çıkarılarak histopatolojik incelemeye alındı. Bulgular: HPE kullanılan grupta histopatolojik sonuçların istatiksel olarak kontrol grubu da dahil olmak üzere en kötü olduğu görüldü. Tedavi gruplarında en iyi sonuçların SR grubu olduğu bunu sırasıyla prednizolon’un takip ettiği görüldü (p

Effects of strontium ranilate and Hypericum perforatum extract on experimental colitis model in rats

Objective: In this study, we aimed to compare the healing effect of strontium ranilate(SR) and hypericum perfaratum(HPE) with the healing effect of prednisolone used in the treatment of experimental colit in rats.Method: 30 wistar albino rats were used in the study. Rats were randomly assigned to 5 consecutive groups consistingof 5 rats. Group 1, healthy rats, group 2 colitis but untreated rats. The rats in groups 3, 4, and 5 had colitis and received160 mg / kg SR, 1mg/kg prednisolone and HP extracts containing 0.3% hiperisine (250 uq / 300 mg) by oral gavage,respectively for seven days. At the end of the seventh day, the colons of the rats were removed and histopathologicalexamination was performed.Results: The histopathological results of the HPE group were statistically worst including the control group. It wasobserved that the best results in the treatment groups were SR group followed by prednisolone group,respectively.(P

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