Persistant hiccups due to the use of intravenous metilprednisolone in a patient wit relapsing remitting multiple sclerosis: a case report and literature review

Hıçkırık, trakenin üzerinden glottisin kapanması ve ani inspirasyon ile takip edilen, diyaframın ani ve kontrol edilemeyen kasılmaları olarak tanımlanabilir. Bu refleks eylemden enstrümentasyon, gastrointestinal, kardiyovasküler, toksik-metabolik faktörler ve ilaçlar gibi çeşitli etiyolojiler sorumludur. Hıçkırığı sıklıkla tetikleyen ilaçlar opiatlar, barbitüratlar, bazı antibiyotikler, kemoterapötik ajanlar ve steroidlerdir. Steroidler nöroloji pratiğinde en sık kullanılan ilaçlardan biri olduğundan, intravenöz metilprednizolon sonrası inatçı hıçkırık ortaya çıkan, atak ve iyileşmelerle giden bir multiple skleroz hastasını, ilacın yan etkisini vurgulamak amacıyla sunduk.

Atak ve iyileşmelerle giden multipl skleroz hastasında kullanımına bağlı inatçı hıçkırık: bir olgu eşliğinde literatürün gözden geçirilmesi

Hiccups can be defined as the sudden, uncontrolled contractions of the diaphragm, followed by immediate inspiration and closure of the glottis over the trachea. Various etiologies are responsible for this reflex action such as instrumentations, gastrointestinal, cardiovascular, toxic-metabolic factors, and drugs. Most common drugs that may trigger hiccups are opioids, barbiturates, some antibiotics, chemotherapeutic agents, and steroids. Since steroids are one of the most common drugs in neurology practice, we here presented a patient with relapsing-remitting multiple sclerosis that experienced persistent hiccups after intravenous methyl- prednisolone treatment, to emphasize the side-effect of the drug.

___

  • 1. Chang FY, Lu CL. Hiccup: Mystery, nature and treatment. J NeurogastroenterolMotil 2012; 18: 1 23-30.
  • 2. Cymet TC. Retrospective analysis of hiccups in patients at a community hospital from 1995-2000. J Natl Med Assoc 2002; 94: 480-3.
  • 3. Kolodzik PW, Eilers MA. Hiccups (singultus): review and approach to management. Annal Emerg Med 1991; 20: 565-73.
  • 4. Steger M, Schneemann M, Fox M. Systemic review: the pathogenesis and pharmacological treatment of hiccups. Aliment Pharmacol Ther. 2015; 42: 1037-50.
  • 5. Greene CL, Oh DS, Worrell SG, Hagen JA. Hiccups and gastroesophageal reflux disease as seen on high resolution esophageal manometry. Dis Esophagus 2014; 29: 883-4.
  • 6. Kahrilas PJ, Shi G. Why do we hiccup? Gut 1997; 41: 712-3.
  • 7. Friedman NL. Hiccups: a treatment review. Pharmacotherapy 1996; 16: 986-95.
  • 8. Peacock ME. Transient hiccups associated with oral dexamethasone. Case Rep Dent 2013; 2013: 426178.
  • 9. Tufan HA, Kocabıyık O, Arıkan S, Gencer B, Kara S, Guneş F. Intractable Hiccups Induced by Oral Methylprednisolone Treatment in a Patient with Behçet's Uveitis. Turk J Ophthalmol 2013; 43: 471-3.
  • 10. Ross J, Eledrisi M, Casner P. Persistent hiccups induced by dexamethasone. West J Med 1999; 170: 51-2.
Cumhuriyet Tıp Dergisi (ELEKTRONİK)-Cover
  • Yayın Aralığı: 4
  • Yayıncı: Cumhuriyet Üniversitesi Tıp Fakültesi
Sayıdaki Diğer Makaleler

Acute inferior ST segment elevation myocardial infarction due to chemotherapy in a young man with testicular cancer

Murat BAYRAK, Veysel TOSUN, Necmettin KORUCUK, Refik Emre ALTEKİN, Mustafa Serkan KARAKAS

Researching the effect of the practical applications performed with cadaver dissection and anatomical models on anatomy education

Mehmet ÇİMEN, Muhittin SÖNMEZ, Selma ÇETİNKAYA, Vedat SABANCIOĞULLARI, Kağan ÇİMEN, Güldal DOĞRUYOL

The effect of Vitamin D treatment on thyroid function and the levels of thyroid autoantibodies, TNF-?, IL-6, IL-1? in patients with autoimmune thyroiditis

Cem CELİK, H Sebila DOKMETAS, Fatih KILICLI, Fettah ACIBUCU, Mustafa AYDEMİR

Domestic violence crimes between 2008- 2011 in Turkey

Sadık TOPRAK

Obscure and mysterious symptom in multiple sclerosis: Pathological laughing and crying

Özge ARICI DÜZ, Nesrin YILMAZ HELVACI, Miraç Ayşen ÇAKMAK ÜNSAL, İlknur CANTÜRK AYDIN, Nihal IŞIK

Assessment of the nurses' work environment using the nursing work index scale

Hatice ULUSOY, Reyhan POLATKAN

An infertile case of 47,XYY syndrome without autistic spectrum: Cost effective well-define of extra Y chromosome by GTG, C bandings, QF-PCR and FISH analyses

Özturk ÖZDEMİR, Ahmet ULUDAĞ, Barış PAKSOY, Mine ORUÇ, Diğdem UYSAL, Atilla GÜRGEN, Fatma SİLAN, Onur YILDIZ

Traumatic life history and co-existing psychiatric disorders in adolescents with a diagnosis of conversion disorder

Ayla UZUN, Seda Aybüke SARI, Esin ÖZATALAY, Emine ÇIĞIL FETTAHOĞLU

Secondary vascular alterations in nutcracker phenomenon and its variants on multidetector CT

Bilge ÖZTOPRAK

Work-related muscoskeletal symptoms and work impairment among workers in Turkish companies

Aliye MANDIRACIOĞLU