Persistant hiccups due to the use of intravenous metilprednisolone in a patient wit relapsing remitting multiple sclerosis: a case report and literature review

Hıçkırık, trakenin üzerinden glottisin kapanması ve ani inspirasyon ile takip edilen, diyaframın ani ve kontrol edilemeyen kasılmaları olarak tanımlanabilir. Bu refleks eylemden enstrümentasyon, gastrointestinal, kardiyovasküler, toksik-metabolik faktörler ve ilaçlar gibi çeşitli etiyolojiler sorumludur. Hıçkırığı sıklıkla tetikleyen ilaçlar opiatlar, barbitüratlar, bazı antibiyotikler, kemoterapötik ajanlar ve steroidlerdir. Steroidler nöroloji pratiğinde en sık kullanılan ilaçlardan biri olduğundan, intravenöz metilprednizolon sonrası inatçı hıçkırık ortaya çıkan, atak ve iyileşmelerle giden bir multiple skleroz hastasını, ilacın yan etkisini vurgulamak amacıyla sunduk.

Atak ve iyileşmelerle giden multipl skleroz hastasında kullanımına bağlı inatçı hıçkırık: bir olgu eşliğinde literatürün gözden geçirilmesi

Hiccups can be defined as the sudden, uncontrolled contractions of the diaphragm, followed by immediate inspiration and closure of the glottis over the trachea. Various etiologies are responsible for this reflex action such as instrumentations, gastrointestinal, cardiovascular, toxic-metabolic factors, and drugs. Most common drugs that may trigger hiccups are opioids, barbiturates, some antibiotics, chemotherapeutic agents, and steroids. Since steroids are one of the most common drugs in neurology practice, we here presented a patient with relapsing-remitting multiple sclerosis that experienced persistent hiccups after intravenous methyl- prednisolone treatment, to emphasize the side-effect of the drug.

___

  • 1. Chang FY, Lu CL. Hiccup: Mystery, nature and treatment. J NeurogastroenterolMotil 2012; 18: 1 23-30.
  • 2. Cymet TC. Retrospective analysis of hiccups in patients at a community hospital from 1995-2000. J Natl Med Assoc 2002; 94: 480-3.
  • 3. Kolodzik PW, Eilers MA. Hiccups (singultus): review and approach to management. Annal Emerg Med 1991; 20: 565-73.
  • 4. Steger M, Schneemann M, Fox M. Systemic review: the pathogenesis and pharmacological treatment of hiccups. Aliment Pharmacol Ther. 2015; 42: 1037-50.
  • 5. Greene CL, Oh DS, Worrell SG, Hagen JA. Hiccups and gastroesophageal reflux disease as seen on high resolution esophageal manometry. Dis Esophagus 2014; 29: 883-4.
  • 6. Kahrilas PJ, Shi G. Why do we hiccup? Gut 1997; 41: 712-3.
  • 7. Friedman NL. Hiccups: a treatment review. Pharmacotherapy 1996; 16: 986-95.
  • 8. Peacock ME. Transient hiccups associated with oral dexamethasone. Case Rep Dent 2013; 2013: 426178.
  • 9. Tufan HA, Kocabıyık O, Arıkan S, Gencer B, Kara S, Guneş F. Intractable Hiccups Induced by Oral Methylprednisolone Treatment in a Patient with Behçet's Uveitis. Turk J Ophthalmol 2013; 43: 471-3.
  • 10. Ross J, Eledrisi M, Casner P. Persistent hiccups induced by dexamethasone. West J Med 1999; 170: 51-2.
Cumhuriyet Tıp Dergisi (ELEKTRONİK)-Cover
  • Yayın Aralığı: Yılda 4 Sayı
  • Yayıncı: Cumhuriyet Üniversitesi Tıp Fakültesi
Sayıdaki Diğer Makaleler

Obscure and mysterious symptom in multiple sclerosis: Pathological laughing and crying

Özge ARICI DÜZ, Nesrin YILMAZ HELVACI, Miraç Ayşen ÇAKMAK ÜNSAL, İlknur CANTÜRK AYDIN, Nihal IŞIK

Treatment of pectus excavatum recurring after open surgery using Nuss procedure: A case report

Tevfik KAPLAN, Bulent KOCER, Neslihan GÜLAY PERİ, Yucel AKKAŞ

Expressed emotion in fibromyalgia: Contribution of spouses' attitude and patients' perception to clinical presentation of fibromyalgia

Derya Güliz MERT, Emrullah HAYTA, Sami HİZMETLİ, Esra SEMİZ AYDINKAL

Researching the effect of the practical applications performed with cadaver dissection and anatomical models on anatomy education

Mehmet ÇİMEN, Muhittin SÖNMEZ, Selma ÇETİNKAYA, Vedat SABANCIOĞULLARI, Kağan ÇİMEN, Güldal DOĞRUYOL

Littler Flap: A reliable option in soft tissue defects of different fingers

Mehmet TAPAN, Ramazan Erkin ÜNLÜ, Ali Rıza YILDIRIM, Burak YAŞAR, Murat İĞDE, Mehmet Onur ÖZTÜRK

Acute inferior ST segment elevation myocardial infarction due to chemotherapy in a young man with testicular cancer

Murat BAYRAK, Veysel TOSUN, Necmettin KORUCUK, Refik Emre ALTEKİN, Mustafa Serkan KARAKAS

Histological approaches to determination of stem cells in neural tube defects which are created experimentally

Serpil SARAYDIN ÜNVER, Zeynep Deniz İNAN ŞAHİN

A rare disorder in an infant with Goldenhar syndrome and nephrolithiasis: Alkaptonuria

Asım GÜLTEKİN, Suar Çakı KILIÇ, Füsun Dilara İÇAĞASIOĞLU, Meryem ÖLMEZ, Demet ALAYGUT

An infertile case of 47,XYY syndrome without autistic spectrum: Cost effective well-define of extra Y chromosome by GTG, C bandings, QF-PCR and FISH analyses

Özturk ÖZDEMİR, Ahmet ULUDAĞ, Barış PAKSOY, Mine ORUÇ, Diğdem UYSAL, Atilla GÜRGEN, Fatma SİLAN, Onur YILDIZ

Correlation of alveolar-arterial gradient with computed tomography pulmonary artery obstruction index in acute pulmonary embolism

Serkan YILMAZ, Gül PAMUKCU, Gülhan ÇELİK KURTOĞLU, Yavuz YİĞİT, Murat MEMİŞ, Onur KARAKAYALI, Halil YILDIRIM, İlyas ERTOK