Bora GÜRER, Zeki ŞEKERCİ, Hüseyin BOZKURT, Hayri KERTMEN, Evrim ÖNDER, Muhammet Taha ESER

Oligodendrogliomlarda osteopontin ekspresyon düzeylerinin histolojik derece ve sağ kalım ile ilişkisi

Oligodendrogliom erişkin dönemin yaygın infiltratif bir gliomudur. DSÖ 2007 sınıflamasıoligodendrogliomları iyi differensiye tümörler (Derece II) ve anaplastik tümörler (Derece III)olmak üzere iki derecede sınıflandırır. Osteopontin ekstrasellüler matriks ilişkili sialik asittenzengin fosfoglikoprotein yapısında integrin bağlayan bir protein olup, farklı tümörlerde derece verekürens gibi parametreler ile ilişkili olduğu yönünde veriler ortaya konmuş olan bir immünbelirteçtir. Bu çalışmamızda Oligodendrogliomlarda Osteopontin ekspresyon oranlarınıimmünohistokimyasal olarak değerlendirerek histolojik derece, rekürens ve sağ kalım ile ilişkisiniaraştırmayı amaçladık. S.B Ankara Dışkapı Eğitim Araştıma Hastanesi Beyin Cerrahisi Kliniğitarafından 2008-2011 yılları arasında ameliyat edilen ve hastanemiz patoloji kliniğinde tanıkonulmuş olan toplam 27 oligodendrogliom olgusu çalışma kapsamına alındı. Bu değerlendirmedeolguların 14 tanesi düşük dereceli (Derece 2, DSÖ 2007), 12 tanesi yüksek dereceli (Anaplastik,Derece 3, DSÖ 2007) oligodendrogliom olarak tanı alırken, 1 olgu Oligodendroglial komponentliGlioblastom (Derece 4, DSÖ 2007) olarak değerlendirildi. Olguların 10 tanesinde Osteopontin ileboyanma yaygınlığı %25in altında izlendi. Bu 10 olgunun 9 tanesi düşük derecelioligodendrogliom, 1 tanesi yüksek dereceli oligodendrogliomdu. Düşük dereceli olgulardan gerikalan 5 tanesinde %25in altında immün boyanma izlendi. Histolojik derece ve Osteopontinekspresyonları göz önüne alındığında yüksek dereceli tümörlerde boyanma yaygınlığı ve boyanmayoğunluğu düşük dereceli tümörlerle karşılaştırıldığında belirgin olarak yüksek düzeyde saptandı(p

The relationship of osteopontin experssion levels with histological grade and survial in oligodendogliomas

Oligodendrogliomas are diffuse infiltrating gliomas of adulthood. The WHO 2007 classificationcriteria classifies oligodendrogliomas as well-differentiated tumors (Grade 2) and anaplastictumors (Grade 3). Osteopontin is a sialic acid-rich phosphoglycoprotein extracellular matrixcomponent and it is an immune marker shown to be associated with parameters such as grade andrecurrence in different tumors. The purpose of this study was to investigate the relationshipbetween osteopontin and histological grades, recurrence and survival in the oligodendrogliomacases by analyzing its expression rates. Twenty-seven cases of oligodendroglioma operated at theTurkish Ministry of Health Ankara Dışkapı Education and Research Hospital, Brain SurgeryClinic between 2008 and 2011 and diagnosed at our hospitals pathology clinic were included inthe study. Fourteen cases were diagnosed as low-grade (Grade 2, WHO 2007) oligodendrogliomaand 12 as high-grade (anaplastic, Grade 3, WHO 2007), and one case was evaluated asglioblastoma with oligodendrogliomal component (Grade 4, WHO 2007). Osteopontin stainingdensity was below the 25% in 10 cases. Nine out of those 10 cases were low-gradeoligodendroglioma and one was high-grade. Immunostaining below the 25% was observed in theremaining five low-grade cases. On the basis of histological grade and expressions of osteopontin,density of staining was significantly higher in the high-grade tumors (p

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