Leptomeningeal carcinomatosis in a younger patient with signet-ring cell carcinoma

Leptomenengeal metastazlar, sistemik kanserli hastaların yaklaşık %3-8inde oluşur. Bu, signet- ring hücreli karsinomu olan hastalarda çok nadirdir. Ama prognoz da çok kötüdür. Meningealkarsinomatozisi olan ve birincil orjini bilinmeyen signet-ring hücreli karsinomu olan genç birbayan olguyu bildiriyoruz.

Taşlı yüzük hücreli karsinomlu genç hastada leptomeningeal karsinomatozis

Leptomeningeal metastasis (LMM) occurs in about 3-8% of patients with systemic cancer. It isvery rare in patients with signet-ring cell carcinoma. But, the prognosis is also very poor. Wereport a case of a younger woman with signet-ring cell carcinoma of primary origin unknown whopresented with meningeal carcinomatosis.

___

  • 1. Posner JB, Chernik NL. Intracranial metastases from systemic cancer. Adv Neurol 1978; 19: 579-92.
  • 2. De Angelis LM. Current diagnosis and treatment of leptomeningeal metastasis. J Neuro- Oncol 1998; 38: 245-52
  • 3. De Angelis LM, Boutros D. Leptomeningeal metastasis. Cancer Invest 2005; 23: 145-54.
  • 4. Wasserstrom WR, Glass JP, Posner JB. Diagnosis and treatment of leptomeningeal metastases from solid tumors: experience with 90 patients. Cancer 1982; 49: 759-72
  • 5. Grant R, Naylor B, Greenberg HS, Junck L. Clinical outcome in aggressively treated meningeal carcinomatosis. Arch Neurol 1994; 51: 457-61
  • 6. Grossman SA, Krabak MJ. Leptomeningeal carcinomatosis. Cancer Treat Rev 1999; 25: 103-19.
  • 7. Kim DY, Lee KW, Yun T, Park SR, Jung JY, Kim DW, Kim TY, Heo DS, Bang YJ, Kim NK. Comparison of intrathecal chemotherapy for leptomeningeal carcinomatosis of a solid tumor: methotrexate alone versus methotrexate in combination with cytosine arabinoside and hydrocortisone. Jpn J Clin Oncol 2003; 33: 608-12.
  • 8. Fuchizaki U, Ohta H, Kaneko S. Image of the month. Gastric signet-ring-cell carcinoma with leptomeningeal carcinomatosis. Gastroenterology 2005; 128: 1773.
  • 9. Lisenko Y, Kumar AJ, Yao J, Ajani J, Ho L. Leptomeningeal carcinomatosis originating from gastric cancer: report of eight cases and review of the literature. Am J Clin Oncol 2003; 26: 165-70.
  • 10. Lee JL, Kang YK, Kim TW, Chang HM, Lee GW, Ryu MH, Kim E, Oh SJ, Lee JH, Kim SB, Kim SW, Suh C, Lee KH, Lee JS, Kim WK, Kim SH. Leptomeningeal carcinomatosis in gastric cancer. J Neurooncol 2004; 66: 167-74.
  • 11. Lee HG, Lee B, Kim SM, Chang HM, Lee GW, Ryu MH, Kim E, Oh SJ, Lee JH, Kim SB, Kim SW, Suh C, Lee KH, Lee JS, Kim WK, Kim SH. A case of gastric adenocarcinoma presenting as meningeal carcinomatosis. Korean J Intern Med 2007; 22: 304-7.
  • 12. Suto C, Oohira A, Funaki C, Kanno S, Mori Y. Pathological findings of optic neuropathy from metastatic leptomeningeal carcinomatosis. Jpn J Ophthalmol 2007; 51: 396-8.
  • 13. Wagemakers M, Verhagen W, Borne B, Venderink D, Wauters C, Strobbe L. Bilateral profound hearing loss due to meningeal carcinomatosis. J Clin Neurosci 2005; 12: 315-8.
  • 14. Nakatsuji Y, Sadahiro S, Watanabe S, Fujimura H, Abe K, Koguchi K, Sakoda S. Leptomeningeal signet-ring cell carcinomatosis presenting with ophthalmoplegia, areflexia and ataxia. Clin Neuropathol 2001; 20: 272-5.
  • 15. Kakar A, Sethi PK, Agarwal CS, Bhalla S, Mahajan M. Leptomeningeal and brain metastasis in a young patient of signet ring cell carcinoma of stomach. J Assoc Physicians India 1998; 46: 320-1.
Cumhuriyet Tıp Dergisi (ELEKTRONİK)-Cover
  • Yayın Aralığı: Yılda 4 Sayı
  • Yayıncı: Cumhuriyet Üniversitesi Tıp Fakültesi
Sayıdaki Diğer Makaleler

Over torsiyonu ve periapandisit birlikteliği

Levent CANKORKMAZ, Gökhan KÖYLÜOĞLU, Hatice ÖZER

Kemik sintigrafisi esnasında skrotal lezyonların görüntülenmesi

Bülent TURGUT, Taner ERSELCAN, Mehmet Fatih BÖRKSÜZ, Serdar Savaş GÜL, Perihan KELKİT, Gürkan ÖZER

The efficacy of micronized flavonoid fraction (450 mg diosmin plus 50 mg hesperidin) in the treatment of lymphedema after axillary dissection

Ümran MUSLU, Özcan ALTINEL, A. Serhat GÜR, Ayşegül DEMİR, Eyüp Sabri TEZCAN, Orhan ÜREYEN, Mustafa ATABEY, Ali Kağan GÖKAKIN

Bir grup kadının ilaç kullanımı ile ilgili bazı davranışları: Akılcı mı?

Meryem YILMAZ, Güngör GÜLER, Nuran GÜLER, Semra KOCATAŞ

Leptomeningeal carcinomatosis in a younger patient with signet-ring cell carcinoma

Saadettin KILIÇKAP, Sevgen ÖNDER, Öztürk ATEŞ, İrem ATEŞ KOR

İntraabdominal kayıp rahim içi aracın laparoskopik olarak çıkarılması: Olgu sunumu ve literatür incelemesi

Emre KARAŞAHİN, Aşkın Evren GÜLER, Mutlu ERCAN, Hakan ÇOKSÜER, İskender BAŞER, İbrahim ALANBAY, Uğur KESKİN

Histopathological effects of fibrin glue in maxillary sinus mucosa: An experimental study

Elif Emine ALTUNTAŞ, Suphi MÜDERRİS, Bilal ÇETİN, Hatice ÖZER

Co-existence of primary biliary cirrhosis and ulcerative colitis

Sabiye AKBULUT, Musa AKOĞLU, Özlem YÖNEM, Birol BOSTANCI, Firdevs TOPAL

PAI-1 4G/4G gene polymorphism is associated with higher serum lipid level in Turkish population.

Hande KURTULGAN KÜÇÜK, Oğuz KARAHAN, Umut Serhat SANRI, Ahmet Turhan KILIÇ, Nurkay KATRANCIOĞLU

Oksipital bölgenin dev lipomu ve beklenmedik zor entübasyon

Salih YILDIRIM, Bilge GÜRELİK, Yılmaz APAYDIN, Mustafa KAKŞİ, İdris ERŞAN, Hüseyin GÖKGÖZ