Okay BULUT, Gonca DONMEZ, Nilgun CEKİN, Zekeriya OZTEMUR, Ergun PİNARBASİ, Aslihan Esra BİLDİRİCİ, Serdal Arslan ARSLAN

FOXP3 Promoter polymorphism (-3499 A/G) is not associated with osteoarthritis in a Turkish population

Amaç: Bu çalışmada FOXP3 geni promotor bölgesi -3499A/G polimorfizmi ile osteoartrit riski arasındaki ilişki bir Türk popülasyonunda araştırılmıştır. Yöntem: Çalışma grubu, 3. evre 50 ve 4. evre 100 OA hastasından, kontrol grubu ise 150 sağlıklı bireyden oluşmuştur. FOXP3 genotipleri PCR-RFLP yöntemleri kullanılarak elde edilmiştir. Bulgular: Sonuçlarımız istatistiksel olarak OA riski ve FOXP3 geni promotor bölgesi -3499A/G polimorfizmi arasında anlamlı bir ilişki olmadığını göstermiştir. Kontrol grubunda doğal tip AA genotipi %63, polimorfik AG %31 ve GG genotipi oranı % 6 bulunurken çalışma gurubunda bu oranlar sırasıyla %56, %37 ve %7 olarak bulunmuştur. Sonuç: Kadınlarda erkeklere oranla daha sık gözlenmiştir ve bu gözlem, önceki çalışmalarda elde edilen sonuçlar ile uyumludur.

Türk popülasyonunda FOXP3 geni promotor polimorfizmi (A-3499G) osteoartit ile ilişkili değildir

Objective: In this study we aimed to find out whether FOXP3 promoter region -3499A/G polymorhism was associated with osteoarthiritis in a Turkish population. Method: The study group consists of 50 patients in 3rd stage and 100 patients in 4th stage osteoarthiritis and control group consists of 150 healthy individuals. FOXP3 genotypes were examined by PCR-RFLP method. Results: Our results show that there is no statisticially significant association between osteoarthiritis and FOXP3 3499A/G polymorphism. The wild type AA genotype was 63%, polymorphic AG was 31% and GG was 6% in the control group, while they were 56%, 37% and 7% in the study group respectively. Conclusions: Osteoarthiritis was seen higher in women than that of men in our study which is compatible with the results of previous results.

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