Anorectal amelanocytic malignant melanoma: Case report

Primer anal malign melanom, anal bölgenin nadir görülen bir patolojisidir. Genellikle anal melanomaya hemoroid ya da anal polip olarak yanlış tanı konulmakta, bununla birlikte tanı ve tedavideki bu gecikme hastalığın komplike bir tablo ile karşımıza çıkmasına neden olmaktadır. Kemoterapi ve radyoterapinin yararlılığı sınırlıdır. Cerrahi standart tedavi yöntemi olup abdominoperineal rezeksiyon (APR) veya genişletilmiş lokal eksizyon en sık tercih edilen yöntemlerdir. Biz bu yazıda 55 yaşında APR ameliyatı yapılan nüks anorektal malign melanomu olan erkek hastayı sunmayı amaçladık.

Anorektal amelanositik malign melanom: Olgu sunumu

Primary anal malignant melanoma is a rare tumor of the anal region. Usually it was misdiagnosed as hemorrhoids or anal polyp so delayed diagnosis can lead complicated status of the disease.Clinical and histopathological diagnosis may be difficult due to uncommon presentation and smilar morphological findings when compared with other malignant anal tumors. Effectiveness of the chemotherapy and radiotheraphy are limited. Surgical resection is still seen as standart treatment option and abdominoperineal resection (APR) and wide local excision are the most preferred methods. In this paper we presented 55 year-old male patient with recurrent anal malignant melanoma treated with abdominoperineal resection.

___

  • 1. Thibault C, Sagar P, Nivatvongs S, et al. Anorectal melanoma -an incurable disease? Dis Colon Rectum 1997; 40: 661- 8.
  • 2. Weinstock MA. Epidemiology and prognosis of anorectal melanoma. Gastroenterology 1993; 104: 174-8. 3. Bulus H, et al. Anorektumun Primer Malign Melanomu: Olgu Sunumu. Ulusal Cerrahi Dergisi 2011; 27: 240-2.
  • 4. Sakız D, et al. Anorektal Malign Melanom: Üç Olgu sunumu. Türk Patoloji Dergisi 2006; 22: 37- 41.
  • 5. Dag A, et al. Anorectal Malign Melanoma: Retrospective Analysis of Surgical Outcomes of 8 Patients. Kolon Rektum Hast Derg 2013; 23: 31-7.
  • 6. Belli F, Gallino GF, Lo Vullo S, et al. Melanoma of the anorectal region: the experience of the National Cancer Institute of Milano. Eur J Surg Oncol 2009; 35: 757-62.
  • 7. Iddings DM, Fleisig AJ, Chen SL, et al. Practice patterns and outcomes for anorectal melanoma in the USA, reviewing three decades of treatment: is more extensive surgical resection beneficial in all patients? Ann Surg Oncol 2010; 17: 40-4.
  • 8. Malik A, Hull T, Floruta C. What is the best surgical treatment for anorectal melanoma? Int J Colorectal Dis 2004; 19: 121-3.
  • 9. Yeh JJ, Shia J, Hwu WJ, et al. The role of abdominoperineal resection as surgical therapy for anorectal melanoma. Annals Surg 2006; 244: 1012-7.
  • 10. Van Schaik PM, Ernst MF, Meijer HA, Bosscha K. Melanoma of the rectum: A rare entity. World J Gastroenterol 2008; 14: 1633-5.
  • 11. Tavusbay C, et al. Primary Malignant Melanoma of the Rectum: Analysis of Six Cases and Review of the Literature. Kolon Rektum Hast Derg 2011; 21: 109-15.
  • 12. Pessaux P, Pocard M, Elias D, et al. Surgical management of primary anorectal melanoma. Brit J Surg 2004; 91: 1183-7.
  • 13. Brady MS, Kavolius JP, Quan SH. Anorectal melanoma. A 64-year experience at Memorial SloanKettering Cancer Center. Dis Colon Rectum 1995; 38: 146-51.
  • 14. Meguerditchian AN, Meterissian SH, Dunn KB. Anorectal melanoma: diagnosis and treatment. Dis Colon Rectum 2011; 54: 638-4.
  • 15. Walls EW. Observations on the microscopic anatomy of the human anal canal. Br J Surg 1958; 45: 504-12.
  • 16. Comstock G, Wynne E, Russell W. DOPA oxidase activity in differential diagnosis of amelanotic melanoma tissue. Cancer Res 1959; 19: 880-3.
  • 17. Fitzpatrick TB. Human melanogenesis. Arch Dermatol 1952; 65: 379-91
Cumhuriyet Tıp Dergisi (ELEKTRONİK)-Cover
  • Yayın Aralığı: Yılda 4 Sayı
  • Yayıncı: Cumhuriyet Üniversitesi Tıp Fakültesi
Sayıdaki Diğer Makaleler

Agresif multipl beyin metastazları ile uzun süre hastalıksız izlem sonrası başvuran ender bir malign plevral mezotelyoma olgusu

Banu OZTURK, Erkan KAYİKCİOGLU, Furkan Bertug CETİN, Asim Armagan AYDİN, Mustafa YİLDİZ

Treatment strategies in advanced Parkinson's disease: Review of the literature

Yıldız DEĞİRMENCİ

Double fenestration of the ipsilateral internal jugular vein

Gökhan YILMAZ, Mehmet H. ATALAR

Acil serviste toplum kökenli pnömoni tanısı alanhastalarda PSI ve CURB-65 pnömoni skorlamasistemlerinin değerlendirilmesi

Umut PAYZA, Fatih Esad TOPAL, Zeynep KARAKAYA, Pınar Yaşim AKYOL, Güzin İLHAN

A study on the antioxidant, antimicrobial and cytotoxic activity of Thymbra spicata L. var. spicata ethanol extract

Mehmet ATAŞ, Özge ÇEVİK, Nuraniye ERUYGUR, Süleyman ÇETİN

Changes emerging with calcinerin inhibition in Caenorhabditis elegans individuals as an aging model

Melih AKYOL, Mustafa TOSUN, Sedat ÖZÇELİK, Sibel BERKSOY HAYTA

Is there diagnostic and prognostic importance of serum anti-p53 antibody level in lung cancer?

Yavuz SİLİG, Birsen YÜCEL, Mehmet Metin ŞEKER, Zekiye HASBEK, Ömer Tamer DOĞAN, Serdar BERK, İsmail SARI, Seyit Ahmet ERTÜRK

Monosodium glutamate below the neurotoxic doses has no cytotoxic effect on mouse mesenchymal stem cells

Şefik GÜRAN, Ertan ALTAYLI, Sümeyye ARSLAN, Nejat Kaan NUROL, Tutku GÖKTEPE, Sinem DAL, Zehra Dilşad ÇOBAN

A case with acute idiopathic blue finger

Rukiye GUNER, Sibel Berksoy HAYTA

The relationship between ABO blood types and development of cerebral venous sinus thrombosis

Aslı BOLAYIR, Burhanettin ÇİĞDEM