Ayça KÖMÜRLÜOĞLU, Selim BADUR, Meral CİBLAK, Yasemin ÖZSÜREKÇİ, Cihangul BAYHAN, Eda KARADAG ÖNCEL, Demet BASER, Mehmet CEYHAN

Role of respiratory viruses in infants less than six months of age with upper respiratory tract infections

Amaç: Solunum yolu enfeksiyonları tüm dünyada özellikle süt çocuklarında mortalite ve morbiditenin önemli bir nedenidir. Bu kesitsel- tanımlayıcı çalışmanın amacı, 6 ay altındaki süt çocuklarında 2013-2014 influenza sezonu boyunca üst solunum yolu enfeksiyonlarından sorumlu olan solunum yolu viruslarının saptanmasıdır.Yöntem: Ocak - Nisan 2014 tarihleri arasında akut üst solunum yolu enfeksiyonu (ÜSYE) semptomları ile başvuran hastalardan nazofaringeal sürüntü (swab) alındı. Örneklerden solunum yolu virusları için RT-PCR çalışıldı.Bulgular: 150 hasta çalışmaya alındı. 126 (% 86) hastada solunum yolu virusları pozitif bulundu. Virus pozitif hastaların 41'inde (% 32.5) RSV, 17'sinde (% 13.4) rinovirus, 15'inde (% 11.9) metapnömovirus, 11'inde (% 8.7) koronavirus, beşinde (% 3.9) adenovirus, ikisinde (% 1.5) parainfluenza ve ikisinde (% 1.5) bokavirus saptandı. Otuz üç (% 26.1) hastanın iki virusle ko-enfeksiyonu olduğu tespit edildi. Burun akıntısı ve komplikasyon gelişimi RT-PCR pozitif hastalarda daha fazla idi (sırasıyla p = 0.023 ve p = 0.019). Tüm komplikasyonlar RT-PCR pozitif grupta özellikle metapnömovirus, RSV ve çoklu virus pozitif hastalarda görüldü. Sonuç: Viral patojen pozitifliği %86 saptanan çalışmamızda, 6 ay altındaki süt çocuklarında influenza virusu görülmediği, RSV ve çoklu viral enfeksiyonların bu yaş grubunda en sık neden olduğu ortaya konmuştur.

Altı ay altındaki süt çocuklarında üst solunum yolu enfeksiyonlarında solunum yolu viruslarının rolü

Objective: With a wide range of clinical presentations, respiratory tract infections remain a significant cause of morbidity and mortality worldwide, particularly in infants. The aim of this cross-sectional descriptive study was to determine the frequency of respiratory viruses responsible for upper respiratory tract infections during the 2013-2014 influenza season in infants less than 6 months of age. Method: Nasal swabs were obtained from patients with symptoms suggestive of an influenza-like illness (ILI) between January and April 2014. Specimens were evaluated by RT-PCR to help identify the causative viral pathogens. Results: A total of 150 patients with ILI were enrolled in the study. A respiratory virus was successfully detected in 126 (86%) infants; RSV in 41 (32.5%), rhinovirus in 17 (13.4%), metapneumovirus in 15 (11.9%), coronavirus in 11 (8.7%), adenovirus in 5 (3.9%), parainfluenza virus in 2 (1.5%) and bocavirus in 2 (1.5%) infants. Thirty-three (26.1%) patients were found to be co-infected with both two viruses. Rhinorrhea and developing complications were significantly more frequently seen in RT-PCR positive patients (p=0.023 and p=0.019, respectively). All complications were seen in RTPCR positive group, especially in metapneumovirus, RSV and multiple viruses positive patients. Conclusions: With an overall viral pathogen detection rate of 86%, findings of our study present that influenza viruses were not seen in infants less than 6 months of age in our study population, whether RSV and multiple viral infections were the most common causes in this age group.

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