Pelin KOPARIR, Akif Evren PARLAK

Bazı Yeni Tiyofen-2,5 Dikarboksilik Asit bis-aril (alkil) amid Bileşiklerinin Antitümör ve Antibakteriyel Özelliklerinin İncelenmesi

Tiyofen türevli bileşikler, çeşitli farmakolojik aktiviteleri nedeniyle kimya, biyoloji ve farmakolojide ilgi uyandırır. Bu çalışma, tiyofen-2,5-dikarboksilik asit bis-aril (alkil) amid bileşiklerinin antitümör ve antibakteriyel aktivitesini araştırmayı amaçlamaktadır. Bu çalışmada, tüm bileşikler için antibakteriyel ve antitümör özellikleri in vitro ortamda belirlenmiştir. Sonuç olarak, hücre canlılığı deneyleri, bu bileşiklerin bazılarının in vitro anti-tümör aktivitesine sahip olduğunu göstermektedir. Ayrıca, bazı bileşiklerin etkili bir antibakteriyel aktiviteye sahip olduğu da bulunmuştur.

Investigation of Antitumor and Antibacterial Properties of Some New Thiophene-2,5-Dicarboxylic Acid bis-aryl (alkyl) amide Compounds

Thiophene-derived compounds are of interest in chemistry, biology and pharmacology because of theirvarious pharmacological activities This study aims to investigate the antitumor and antibacterial activity ofthiophene-2,5-dicarboxylic acid bis-aryl (alkyl) amide compounds. In this study, the properties of antibacterialand antitumor were determined in vitro media, for all compounds.As a result, cell viability experiments show that some of this compounds have effective in vitro antitumoractivity. In addition, it has also been found that some compounds have an effective antibacterial activity.

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