Kerem SUTCU, Şemsettin OSMANOGLU

Bazı İlaç Tozlarında Radyasyon Etkisinin Elektron Paramanyetik Rezonans İncelenmesi

Bu çalışmada, elektron paramanyetik rezonans spektroskopisi ile ışınlama sonrası oluşan paramanyetik türlerin radyasyon duyarlılığını saptamak için sülfadimetoksin, pirazinamid ve kloramfenikol numunelerine 1- 15 kilogray dozunda gama ışınları uygulandı. İlk olarak, numunelerin elektron paramanyetik rezonans sinyal şiddetleri, mikrodalga gücünün bir fonksiyonu olarak oda sıcaklığında incelendi. Işınlanmamış örneklerden herhangi bir sinyal elde edilmezken, ışınlanmış numuneler belirgin spektrumlar sergiledi. Ek olarak, radikallerin kararlılıklarını incelemek amacıyla numunelerin zamana bağımlılığı analiz edildi.

Electron Paramagnetic Resonance Investigation of Radiation Effect on Certain Types of Drug Powders

In this study, gamma rays were applied to the sulfadimethoxine, pyrazinamide, andchloramphenicol in the dose range of 1-15 kilogray, in order to detect radiosensitivity of paramagneticspecies, which are formed after irradiation by electron paramagnetic resonance spectroscopy. Firstly, theintensities of electron paramagnetic resonance signals of the samples as a function of the microwave powerwere investigated at room temperature. While no signal was obtained from the unirradiated samples, theirradiated samples exhibited significant spectra. Additionally, the time dependency of the samples wasanalyzed to study the stability of the radicals.

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