Derya KARPUZ, Ozlem TEZOL, Baki KARA, Yusuf USTA, Olgu HALLIOĞLU

Subklinik Çölyak hastalığı olan çocuklarda erken ateroskleroz riskinin aortik elasitisite parametreleri ile belirlenmesi

Amaç: Bu çalışma çölyak hatsalığı (ÇH) olan çocuklarda artmış aortik elastisite parametrelerinin ve miyokard fonksiyonlarının birlikte değerlendirildiği ve subklinik myokard hasarının esneklik parametreleri üzerine etkisinin incelenmeyi amaçlamıştır..Gereç ve Yöntem: Çalışmaya 52 CH ve yaş ve cinsiyet yönünden benzer 60 sağlıklı çocuk alındı. Hastalar antitissue transglutaminase (anti-tTG) antibody sonuçlarına göre iki gruba ayrıldı. Tüm çocukların kardiyak fonksiyonları konvensiyonel ekokardiyografi ve doku Doppler (TDI) görüntüleme yöntemiyle değerlendirildi. M-mode ekokardiyografi ile aortik strain, distensibilite ve stiffness index (SI) hesaplandı. Bulgular: Hastaların demografik verileri ve laboratory characteristics kontrolere benzerdi. Her iki ventrikül için TDI ile değerlendirilen ICT and IRT values ve Tei index anlamlı yüksekti. RV Tei index value was the highest in the group of serum anti-tTG antibody pozitive. Patient group exihibited significantly lower strain values and higher SI than the controls. Sonuç: Bu çalışma subklinik CD’li çocuklarda aortik elastisite parametreleri ile prematür ateroskleroz riskinin arttığı ve bunun arteriyel basınç ile ilişkili olduğunu gösterdi. Bu sonuçlar özellikle antikor pozitif CD’li çocuklarda ekokardiyografik izlem ile oluşabilecek ciddi kardiyovasküler komplikasyonların öngörülebileceğini düşündürmektedir.

Anahtar Kelimeler:

Çölyak hastalığı, doku Doppler echocardiography, doku transglutaminaz-IgA

Determination of early atherosclerosis risk with aortic elasticity parameters in children with subclinical Celiac disease

Purpose: The aim of this study was to evaluate increased aortic elasticity parameters and myocardial function in children with celiac disease (CD) and the effect of the subclinical myocardial damage on the elasticity parameters. Materials and Methods: Fiftytwo children with CD and 60 healthy subjects were included in the study. Patients were divided into two groups according to IgA-tissue transglutaminase (IgA-tTG) antibody results. All children's cardiac functions were assessed by conventional echocardiography and tissue Doppler (TDI) imaging. Aortic strain, distensibilty and stiffness index (SI) were calculated by M-mode echocardiography. Results: Isovolumetric contraction time and isovolumetric relaxation time values and myocardial performance index (Tei) evaluated for both ventricles by TDI were significantly higher in patients. Right ventricle Tei index value was the highest in the group of serum IgA-tTG antibody positive. Patient group exhibited significantly lower strain values and higher SI than the controls. Conclusion: Our study showed that aortic elasticity parameters in children with subclinical CD are related to arterial pressure and may be used to determine increased prematurity atherosclerosis risk. These results suggest that serious cardiovascular complications can be predicted with echocardiographic follow-up especially in children with antibody-positive CD.

Keywords:

Celiac disease, tissue Doppler echocardiography, IgA-tissue transglutaminase,

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