Soner SOLMAZ, Fettah ACIBUCU, Enver SANCAKDAR, Çiğdem GEREKLİOĞLU, Aslı KORUR, Duygu OĞUZ ACIBUCU

Demir tedavisi alan hastalarda leptin ve kilo alımı arasındaki ilişki

Amaç: Bu çalışmanın amacı demir tedavisi alan hastalarda leptin ve kilo artışı arasındaki ilişkiyi saptamaktır.Gereç ve Yöntem: Toplamda 42 demir eksikliği anemisi tanısı konulan kadın hasta çalışmaya dahil edilmiştir. Tanı anında ve tedavi başlandıktan 1 ay sonra tam kan sayımı, serum demir, ansature demir bağlama kapasitesi ve ferritin seviyesi, tanı anında ve tedavi başlandıktan sonra 96. saatte serum hepsidin ve leptin seviyesi ölçüldü. İştahta meydana gelen değişiklikler ve vücut ağırlığı tanı anında ve tedavi başlandıktan 1 ay sonra değerlendirildi.Bulgular: Tanı anındaki ve tedavi başlandıktan sonraki serum hepsidin ve leptin seviyeleri arasında istatistiksel olarak anlamlı fark bulunmadı. 22 (%52.4) hastada iştah artışı olduğu tespit edildi. Tanı anında hastaların ortalama ağırlığı 69.6±17.9 kg olarak tespit edilmiş iken tedavi başlandıktan 1 ay sonra hastaların ağırlığı 70.7±17.5 kg olarak bulunmuştur ve değerler arasında istatistiksel olarak anlamlı fark tespit edilmiştir.Sonuç: Çalışmamız gözlemlerimiz ve hipotezimizle uyumlu olarak demir tedavisini takiben hastalarda iştah artışı ve ağırlık artışı meydana geldiği saptanmıştır. Leptin düzeyleri ile kilo artışı arasında bir ilişki bulunmamıştır. .

Anahtar Kelimeler:

Demir, hepsidin, leptin, iştah, kilo artışı

Association between leptin and weight gain in patients receiving iron treatment

Purpose: The aim of this study was to evaluate the relationship between leptin and weight gain in patients receiving iron treatment.Materials and Methods: A total of 42 female patients who were diagnosed with IDA were included in the study. Whole blood count, serum iron, serum unsaturated iron binding capacity (UIBC), serum ferritin level were measured at the time of diagnosis and on month one after treatment; serum hepcidin level and serum leptin level were measured at the time of diagnosis and 96 hours after commencement of parenteral therapy; body weight and appetite alterations were recorded at the time of diagnosis and on month one.Results: A statistically significant difference was not found between hepcidin and leptin values at the time of diagnosis and after treatment. Increased appetite was detected in 22 (52.4%) patients on month one after treatment. While mean weight of all patients was 69.6±17.9 kg at the time of diagnosis, it was 70.7±17.5 kg on month one after treatment and there was a statistically significant difference between two values. Conclusion: Our study revealed that appetite and body weight increased following iron therapy, consistently with our observations and hypothesis. However no significant relationship was found with leptin levels and weight increase.

Keywords:

Iron, leptin, hepcidin, appetite, weight gain,

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