Burkay YAKAR, Gamzecan KARAKAYA, Erhan ÖNALAN, Mehmet Ferit GÜRSU

Serum kartonektin (CTRP-3) düzeyinin gestasyonel diyabetli ve sağlıklı gebelerde karşılaştırılması ve biyokimyasal parametreler ve insulin direnci ile ilişkisi

Amaç: Bu çalışmada gestasyonel diyabet mellitus (GDM) tanısı alan gebelerin serum kartonektin (CTRP-3) sevilerinin sağlıklı kontrol gebe grubu ile karşılaştırılması ve Kartonektin düzeyinin gebelerin biyokimyasal parametreleri ile ilişkisinin incelenmesi amaçlanmıştır. Gereç ve Yöntem: Kesitsel tipte tasarlanan araştırma Haziran 2016 ile Ocak 2017 tarihleri arasında yürütülmüştür. Çalışmaya 24-32 haftalık 30 GDM ve 30 sağlıklı gebe dahil edildi. Tüm katılımcılardan 12 saat açlık sonrası kan şekeri, lipid paneli, insulin, c-peptid ve kartonektin düzeyleri elde edilmiştir. Bulgular: Gestasyonel diyabeti olan katılımcıların Glikoz, HbA1C, İnsulin, C-peptid, HOMA-IR, Trigliserit, VLDL, HDL düzeyleri istatistiksel olarak kontrol grubundan yüksek saptandı. Kontrol grubunun kartonektin (CTRP-3) düzeyi 7.68±4.29 (ng/mL), GDM grubunun ortalama kartonektin düzeyi 6.95±4.02 (ng/mL) saptandı ve iki grup arasında istatistiksel anlamlı bir fark saptanmadı Sonuç: GDM’lu hasta grubunda glikoz, HbA1c, insulin, HOMA-IR, C-peptid, trigliserit ve VLDL düzeylerinin yükseldiği saptanmıştır. Gestasyonel diyabetli hastalarda kartonektin ile glikoz ve insülin düzeyleri arasında negatif korelasyon saptanmıştır.

Comparison of serum cartonectin (CTRP-3) level in gestational diabetes patient and healthy pregnant women and its relationship with biochemical parameters and insulin resistance

Purpose: The aim of this study was to compare the serum cartonectin (CTRP-3) levels of patients with gestational diabetes mellitus with the healthy control pregnant group and to investigate the relationship of cartonectin with the biochemical parameters of pregnant women. Material and Methods: The cross-sectional study was conducted between June 2016 and January 2017. A total of 30 patients with GDM and 30 healthy pregnant women were included in the study. Glucose, lipid, insulin, c-peptide and cartonectin levels were obtained from all participants after 12 hours of fasting. Results: Participants with gestational diabetes glucose, HbA1C, insulin, C-peptide, HOMA-IR, triglyceride, VLDL, HDL levels were statistically higher than the control group. Cartonectin level of the control group was 7.68 ± 4.29, mean cartonectin level of the GDM group was 6.95 ± 4.02 (ng / mL) and there was no statistically significant difference between the two groups. Conclusion: Glucose, HbA1c, insulin, HOMA-IR, C-peptide, triglyceride and VLDL levels were increased in patients with GDM. Negative correlation was found between cartonectin and glucose and insulin levels in patients with gestational diabetes.

Keywords:

diabetes, cartonectin,

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