Sule TERZİOGLU-USAK, Aleyna DAL, Hilal YANIK, Birsen ELİBOL

Müziğin strese bağlı indüklenen hormonlar ve oksidatif stres üzerine etkisi

Amaç: Perinatal stresin, kaygı ve depresyonun organizmaların gelişim dönemini etkilediği düşünülmektedir. Bu çalışmada perinatal dönemde farklı müzik türlerine maruz kalmış sıçanların depresyon benzeri davranışları, adrenokortikotropik hormon (ACTH), kortikosteron (CORT) ve paratiroid hormon (PTH) serum düzeyleri ile serum oksidatif stres üzerindeki etkilerini araştırmayı amaçladık. Gereç ve Yöntem: Gebe Wistar albino sıçanlar rastgele dört kafese ayrıldı; kontrol grubu (müzik yok), klasik müzik grubu (D Major'da Canon / Johann Pachelbel, 60 dB), geleneksel Sufi müzik grubu (Whirling Derwish / Omar Faruk Tekbilek, 30 dB) ve metal müzik grubu (In Your Face/ Children of Bodom, 120 dB). Her müzik grubundaki anneler ve yavrular, hamileliğin 10. gününden doğumdan sonra 21. güne kadar 1 saat / gün kendi müzik türlerine maruz bırakıldılar. Bulgular: Kuyruktan asma testi sonuçlarına göre klasik müzik grubunda depresyon düzeyini gösteren hareketsizliğin kontrol grubuna göre arttığı gözlenmiştir. Hormonal düzeyde, sadece serum ACTH seviyelerinde önemli değişiklikler elde edilmiştir. Bu değer kontrol grubuna göre klasik müzik grubunda artarken, tasavvuf müzik grubunda azalmıştır. Ayrıca metal müzik grubunda kontrol grubuna göre oksidatif stres endeksinde belirgin bir artış saptanmıştır. Sonuç: Hamilelik sırasında dinlenen müziğin ses yoğunluğu, yavruların ileri yaşamlarındaki stres ve depresyon düzeyinde hayati önem taşımaktadır.

Effects of music on stress induced hormones and oxidative stress levels

Purpose: Perinatal stress, anxiety, and depression have been thought having influences on the developmental period of organisms. In this study, we aimed to investigate the effects of different types of music exposure during perinatal period on depression-like behavior, serum levels of adrenocorticotropic hormone (ACTH), corticosterone (CORT) and parathyroid hormone (PTH) as well as serum oxidative stress index in rats. Materials and Methods: Pregnant Wistar albino rats were randomly divided into four cages; the control group (no music exposure), the classical music group (Canon in D Major/ Johann Pachelbel, 60 dB), the traditional Sufi music group (Whirling Derwish/ Omar Faruk Tekbilek, 30 dB), and the rock music group (In Your Face/ Children of Bodom, 120 dB). Dams and pups in each music groups listened to their own music 1 hour/day from gestational day 10 to postnatal day 21. Results: According to the results of tail suspension test, the longer duration of immobility which shows the level of depression was increased in the classical music group compared to the control group. At hormonal level, significant alterations were obtained only in serum ACTH levels. It was increased in the classical music group, while decreased in the sufi music group compared to the control group. In addition, a marked increase in oxidative stress index was found in the rock music group compared to the control group. Conclusion: The sound intensity of music which is listened during the pregnancy has vital importance in the stress and depression level of offspring.

Keywords:

Hypothalamic-pituitary-adrenal (HPA) axis perinatal music, depression-like behavior, parathyroid hormone (PTH), oxidative stress,

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