Bahadır DEMİR, Aslıhan GÜMÜŞLÜ, Şengül ŞAHİN, Gulcin ELBOGA, Abdurrahman ALTINDAĞ

Obsesif kompulsif bozuklukta serum doğal antioksidan düzeyleri

Amaç: Bu çalışmada obsesif kompulsif bozukluk (OKB) hastalarında ürik asit, albümin, total bilirubin ve gamma glutamil transferaz (GGT) gibi serumda ölçülebilen oksidatif stres ile ilişkili basit laboratuvar parametrelerini sağlıklı kontroller ile karşılaştırılması amaçlanmıştır. Gereç ve Yöntem: Çalışmaya Gaziantep Üniversitesi Tıp Fakültesi Hastanesi Psikiyatri polikliniğinde DSM-5 kriterlerine göre OKB tanısı ile tedavi edilen hastalar alınmıştır. OKB tanısı konulan 117 hasta ve hasta grubu ile demografik veriler ile eşleşebilecek 80 kişi sağlıklı kontrol grubu olarak alındı. Hasta ve kontrol grubu serum ürik asit, albümin, total bilirubin ve GGT açısından karşılaştırıldı. Hastaların klinik özellikleri Yale Brown Obsesyon Kompulsiyon Ölçeği (Y-BOCS) ve Klinik Global İzlenim Şiddet Ölçeği (KGI-S) ile değerlendirildi. Bulgular: Hasta grubu yaş ortalaması 36.68±13.06 iken kontrol grubunun 35.54±8.82’di. Total bilirubin düzeyine bakıldığında hasta grubunda 0.69±2.19 mg/dL ve kontrol grubunda 0.63±0.47 mg/dL olmakla birlikte gruplar arasında anlamlı farklılık vardı. GGT düzeyi hasta grubunda 22.85±15.80 U/L ve kontrol grubunda ise 19.29±11.52 U/L olmakla birlikte gruplar arasında anlamlı fark yoktu. Sonuç: Hastalar bilirubin dışında doğal antioksidan açısından kontrollerden farklı değildi. Çalışmamızdaki bulgular OKB ile ürik asit, albümin ve GGT arasında nedensel bir ilişki olduğunu desteklememektedir.

Serum natural antioxidant levels in obsessive-compulsive disorder

Purpose: The aim of this stıudy was to examine easy laboratory parameters associated with oxidative stress that can be measured in serum such as uric acid, albumin, total biluribine and gamma glutamyl transferase (GGT) in patients with obsessive compulsive disorder (OCD) by comparing them with healthy controls. Materials and Methods: 117 Patients who were diagnosed as OCD according to DSM-5 criteria and 80 healthy controls were included in the study. Patient and control groups were compared in terms of serum uric acid, albumin, total biluribine and GGT. Yale Brown Obsession Compulsion Scale and Clinical Global Impression Scale were used to assess clinical characteristics of the patients. Results: The mean age of the patients was 36.68±13.06 years, while it was 35.54±8.82 in control group. Total biluribin levels was higher in patients (0.69±2.19 mg/dL) than controls (0.63±0.47 mg/dL). Although the GGT level was 22.85 ± 15.80 U / L in the patient group and 19.29 ± 11.52 U / L in the control group, there was no significant difference between the groups. Conclusion: Patients did not differ from controls in terms of natural antioxidant, except bilirubin. The results do not support a causal relationship between OCD and uric acid, albumine and GGT.

Keywords:

Obsessive compulsive disorder oxidative stress, uric acid, albumin, bilirubine, gamma glutamyl transferase,

PDF

___

1. Maia A, Oliveira J, Lajnef M, Mallet L, Tamouza R, Leboyer M et al. Oxidative and nitrosative stress markers in obsessive–compulsive disorder: a systematic review and meta‐analysis. Acta Psychiatrica Scandinavica. 2019;139(5):420-33.
2. Ruscio AM, Stein DJ, Chiu WT, Kessler RC. The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication. Molecular Psychiatry. 2010;15(1):53-63.
3. Olatunji BO, Davis ML, Powers MB, Smits JA. Cognitive-behavioral therapy for obsessive-compulsive disorder: A meta-analysis of treatment outcome and moderators. Journal of Psychiatric Research. 2013;47(1):33-41.
4. Erzegovesi S, Cavallini MC, Cavedini P, Diaferia G, Locatelli M, Bellodi L. Clinical predictors of drug response in obsessive-compulsive disorder. Journal of Clinical Psychopharmacology. 2001;21(5):488-92.
5. Bokor G, Anderson PD. Obsessive–compulsive disorder. Journal of Pharmacy Practice. 2014;27(2):116-30.
6. Gray SM, Bloch MH. Systematic review of proinflammatory cytokines in obsessive-compulsive disorder. Current Psychiatry Reports. 2012;14(3):220-8.
7. Atlan N, Sepici Dinçel A, Koca C. Diabetes mellitus ve oksidatif stres. Türk Biyokimya Dergisi. 2006;31(2):51-6.
8. Yavuz BB, Yavuz B, Halil M, Cankurtaran M, Ulger Z, Cankurtaran ES et al. Serum elevated gamma glutamyltransferase levels may be a marker for oxidative stress in Alzheimer's disease. International Psychogeriatrics. 2008;20(4):815-23.
9. American Psychiatric Association. Diagnostic and statistical manual of mental disorders (DSM-5®). American Psychiatric Pub, 2013.
10. Goodman WK, Price LH, Rasmussen SA, Mazure C, Fleischmann RL, Hill CL et al. The Yale-Brown obsessive compulsive scale: I. Development, use, and reliability. Archives of General Psychiatry. 1989;46(11):1006-11.
11. Goodman WK, Price LH, Rasmussen SA, Mazure C, Delgado P, Heninger GR et al. The yale-brown obsessive compulsive scale: II. Validity. Archives of General Psychiatry. 1989;46(11):1012-6.
12. Guy, William. ECDEU assessment manual for psychopharmacology. US Department of Health, Education, and Welfare, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute of Mental Health, Psychopharmacology Research Branch, Division of Extramural Research Programs, 1976.
13. Şahin Ş, Aybastı Ö, Elboğa G, Altındağ A, Tamam L. Major depresyonda elektrokonvulsif terapinin oksidatif metabolizma üzerine etkisi. Cukurova Medical Journal. 2017;42(3):513-7.
14. Kuloglu M, Atmaca M, Tezcan E, Gecici Ö, Tunckol H, Ustundag B. Antioxidant enzyme activities and malondialdehyde levels in patients with obsessive-compulsive disorder. Neuropsychobiology. 2002;46(1):27-32.
15. Ozdemir E, Cetinkaya S, Ersan S, Kucukosman S, Ersan EE. Serum selenium and plasma malondialdehyde levels and antioxidant enzyme activities in patients with obsessive–compulsive disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2009;33(1):62-5.
16. Atmaca M, Tezcan E, Kuloglu M, Ustundag B. Plasma nitrate values in patients with obsessive‐compulsive disorder. Psychiatry and Clinical Neurosciences. 2005;59(5):621-3.
17. Chakraborty S, Singh OP, Dasgupta A, Mandal N, Das HN. Correlation between lipid peroxidation-induced TBARS level and disease severity in obsessive–compulsive disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2009;33(2):363-6.
18. Cankurtaran M, Yesil Y, Kuyumcu ME, Oztürk ZA, Yavuz BB, Halil M et al. Altered levels of homocysteine and serum natural antioxidants links oxidative damage to Alzheimer's disease. Journal of Alzheimer's Disease. 2013;33(4):1051-8.
19. Keshavarz M, Khosravizadegan F, Bibak A. Serum uric acid levels in different phases of acute severe manic and depressed patients. Arch Neurosci. 2016;3(2):e30236.
20. Luo Q, Wen Z, Li Y, Chen Z, Long X, Bai Y et al. Assessment causality in associations between serum uric acid and risk of schizophrenia: a two-sample bidirectional mendelian randomization study. Clinical Epidemiology. 2020;12:223.
21. Lyngdoh T, Bochud M, Glaus J, Castelao E, Waeber G, Vollenweider P et al. Associations of serum uric acid and SLC2A9 variant with depressive and anxiety disorders: a population-based study. PloS one. 2013;8(10):e76336.
22. Chen S, Xia HS, Zhu F, Yin GZ, Qian ZK, Jiang CX et al. Association between decreased serum albumin levels and depressive symptoms in patients with schizophrenia in a Chinese Han population: A pilot study. Psychiatry Research. 2018;270:438-42.
23. Keebaugh AC, Thomas JW. The evolutionary fate of the genes encoding the purine catabolic enzymes in hominoids, birds, and reptiles. Molecular Biology and Evolution. 2010;27(6):1359-69.
24. Honggang W, Lizhen W, Rui X, Weijie D, Chengcheng G, Peng S et al. Association of serum uric acid with body mass index: a cross-sectional study from Jiangsu Province, China. Iranian Journal of Public Health. 2014;43(11):1503.
25. Soriani M, Pietraforte D, Minetti M. Antioxidant potential of anaerobic human plasma: role of serum albumin and thiols as scavengers of carbon radicals. Archives of Biochemistry and Biophysics. 1994;312(1):180-8.
26. Yao JK, Reddy R, van Kammen DP. Abnormal age-related changes of plasma antioxidant proteins in schizophrenia. Psychiatry Research. 2000;97(2-3):137-51.
27. Kuyumcu ME, Yesil Y, Oztürk ZA, Cınar E, Kızılarslanoglu C, Halil M et al. The association between homocysteine (hcy) and serum natural antioxidants in elderly bone mineral densitometry (BMD). Archives of Gerontology and Geriatrics. 2012;55(3):739-43.
28. De Berardis D, Conti C, Campanella D, Carano A, Di Giuseppe B, Valchera A et al. Evaluation of plasma antioxidant levels during different phases of illness in adult patients with bipolar disorder. Journal of Biological Regulators & Homeostatic Agents. 2008;22(3):195.
29. Radhakrishnan R, Kanigere M, Menon J, Calvin S, Janish A, Srinivasan K. Association between unconjugated bilirubin and schizophrenia. Psychiatry Research. 2011;189(3):480-2.