Karotis elastisite ve distensibilitesinin son dönem böbrek yetmezliği olan hastalar ve sağlıklı gönüllüler arasında karşılaştırılması

Amaç: Son dönem böbrek yetmezliği olan kronik böbrek hastalarında kardiyovasküler olayların sıklığının artığı bilinmektedir ancak böbrek yetmezliğinin karotis arterler üzerinde nasıl bir etki gösterdiği net değildir. Bu çalışmanın amacı bunu değerlendirmektir. Bu amaçla subklinik karotis aterosklerozu ve hasarını gösteren elastisite ve distensibilite son dönem böbrek yetmezliği olan hastalar ve sağlıklı populasyonda ölçülerek karşılaştırılmıştır.Gereç ve Yöntem: Çalışma kesitsel olarak planlandı. Son dönem böbrek yetmezliği olan 61 hasta ve 58 sağlıklı gönüllünün karotis elastisitesi ve distensibilitesi ölçülerek aralarında istatistiksel anmalı fark olup olmadığı değerlendirildi. Ayrıca hasta grubundaki bireylerin diyalize girme süreleri ile karotis elastisitesi ve distensibilitesi arasında anlamlı korelasyon olup olmadığı araştırıldı.Bulgular: Hasta grubundahem karotis elastisitesi hem de distensibilitesi istatistiksel anlamlı olarak daha düşüktü (0,12±0,02 vs. 0,23±0,04, p < 0,001, ve 7,47±0,51 vs. 9,42±0,73, p < 0,001, sırasıyla). Diyaliz süresi ile hem karotis elastisitesi hem de karotis distensibilitesi arasında istatistiksel anlamlı negatif yönlü korelasyon bulundu (r = -0,783, p < 0,001 ve r = -0,385, p = 0,002, sırasıyla).Sonuç: Son dönem böbrek yetmezliği olan hastalarda karotis elastisitesi ve distensibilitesi azalmıştır. Bu sonuçları bize bu hasta grubunda karotis arterlerde subklinik ateroskleroz riskinin arttığını düşündürebilir, ayrıca serebrovasküler olay riskindeki artışın sebebinin karotis arterlerdeki ateroskleroz olduğunu da indirekt olarak düşündürebilir.

Anahtar Kelimeler:

Böbrek yetmezliği, doppler, karotis

Comparison of carotid elasticity and distensibility between patients with end-stage renal disease and healthy volunteers

Purpose: The incidence of cardiovascular events increased in patients with end-stage renal disease, but it is not clear how renal failure affects carotid arteries. The aim of this study is to evaluate this affect. For this purpose, the elasticity and distensibility which are markers of subclinical carotid atherosclerosis were measured and compared in patients with end-stage renal disease and healthy population.Materials and Methods: The study was planned as cross-sectional. A total of 119 subjects (61 patients and 58 control) were enrolled into the study. Carotid elasticity and distensibility were measured and compared between the groups. In addition, we investigated whether there was a significant correlation between the duration of dialysis and carotid elasticity and distensibility.Results: Carotid elasticity and distensibility were significantly lower in the patient group than in the control group (0.12±0.02 vs. 0.23±0.04, p < 0.001, and 7.47±0.51 vs. 9.42±0.73, p < 0.001, respectively). Correlation analysis revealed a significant positive correlation between the duration of dialysis and carotid elasticity and distensibility (r = -0.783, p < 0.001 ve r = -0.385, p = 0.002, respectively).Conclusion: Carotid elasticity and distensibility decreased in patients with end-stage renal disease. These results may suggest an increased risk of subclinical atherosclerosis in the carotid arteries in this patient group and may indirectly suggest that the increase in the risk of cerebrovascular event is caused by atherosclerosis in the carotid arteries.

Keywords:

Carotid, kidney,

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